{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:32:51Z","timestamp":1774470771197,"version":"3.50.1"},"reference-count":52,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"DOI":"10.14341\/probl12699","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T10:00:25Z","timestamp":1613383225000},"page":"20-30","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":6,"title":["Selective screening of patients with associated somatic diseases as a method of early detection of acromegaly"],"prefix":"10.14341","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-2997","authenticated-orcid":true,"given":"M. B.","family":"Antsiferov","sequence":"first","affiliation":[{"name":"Endocrinological dispensary of Moscow Healthcare Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-798X","authenticated-orcid":true,"given":"V. S.","family":"Pronin","sequence":"additional","affiliation":[{"name":"Russian medical Academy of continuing professional education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-845X","authenticated-orcid":true,"given":"T. M.","family":"Alekseeva","sequence":"additional","affiliation":[{"name":"Endocrinological dispensary of Moscow Healthcare Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-035X","authenticated-orcid":true,"given":"O. A.","family":"Ionova","sequence":"additional","affiliation":[{"name":"Endocrinological dispensary of Moscow Healthcare Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-4772","authenticated-orcid":true,"given":"E. Y.","family":"Martynova","sequence":"additional","affiliation":[{"name":"LLC \u00abRelevant medicine\u00bb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-756X","authenticated-orcid":true,"given":"Yu. E.","family":"Poteshkin","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University (Pirogov Medical University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-2810","authenticated-orcid":true,"given":"N. A.","family":"Chubrova","sequence":"additional","affiliation":[{"name":"Moscow state medical University named after I.M. Sechenov (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-5907","authenticated-orcid":true,"given":"K. Y.","family":"Zherebchikova","sequence":"additional","affiliation":[{"name":"Moscow state medical University named after I.M. Sechenov (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"ref1","unstructured":"Dedov II, Melnichenko GA. Acromegaly: pathogenesis, clinic, diagnosis, differential diagnosis, treatment methods. Manual for doctors. Moscow; 2012. 80 p. (in Russ.)."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Bolanowski M, Rucha\u0142a M, Zgliczy\u0144ski W, et al. Diagnostics and treatment of acromegaly \u2014 updated recommendations of the Polish Society of Endocrinology. Endokrynol Pol. 2019;70(1):2-18. doi: https:\/\/doi.org\/10.5603\/EP.a2018.0093","DOI":"10.5603\/EP.a2018.0093"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS. Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis. Eur J Endocrinol. 2018;179(1):59-71. doi: https:\/\/doi.org\/10.1530\/EJE-18-0255","DOI":"10.1530\/EJE-18-0255"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Dekkers OM, Biermasz NR, Pereira AM, et al. Mortality in Acromegaly: A Metaanalysis. J Clin Endocrinol Metab. 2008;93(1):61-67. doi: https:\/\/doi.org\/10.1210\/jc.2007-1191","DOI":"10.1210\/jc.2007-1191"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kasuki L, Rocha P da S, Lamback EB, Gadelha MR. Determinants of morbidities and mortality in acromegaly. Arch Endocrinol Metab. 2020;63(6):630-637. doi: https:\/\/doi.org\/10.20945\/2359-3997000000193","DOI":"10.20945\/2359-3997000000193"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Hong JW, Ku CR, Kim SH, Lee EJ. Characteristics of Acromegaly in Korea with a Literature Review. Endocrinol Metab. 2013;28(3):164. doi: https:\/\/doi.org\/10.3803\/EnM.2013.28.3.164","DOI":"10.3803\/EnM.2013.28.3.164"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Butz LB, Sullivan SE, Chandler WF, Barkan AL. \u201cMicromegaly\u201d: an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era. Pituitary. 2016;19(6):547-551. doi: https:\/\/doi.org\/10.1007\/s11102-016-0735-0","DOI":"10.1007\/s11102-016-0735-0"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Jallad RS, Bronstein MD. Acromegaly in the elderly patient. Arch Endocrinol Metab. 2020;63(6):638-645. doi: https:\/\/doi.org\/10.20945\/2359-3997000000194","DOI":"10.20945\/2359-3997000000194"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Lavrentaki A, Paluzzi A, Wass JAH, Karavitaki N. Epidemiology of acromegaly: review of population studies. Pituitary. 2017;20(1):4-9. doi: https:\/\/doi.org\/10.1007\/s11102-016-0754-x","DOI":"10.1007\/s11102-016-0754-x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Zahr R, Fleseriu M. Updates in Diagnosis and Treatment of Acromegaly. Eur Endocrinol. 2018;14(2):57. doi: https:\/\/doi.org\/10.17925\/EE.2018.14.2.57","DOI":"10.17925\/EE.2018.14.2.57"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Zarool-Hassan R, Conaglen HM, Conaglen JV, Elston MS. Symptoms and signs of acromegaly: an ongoing need to raise awareness among healthcare practitioners. J Prim Health Care. 2016;8(2):157\u2013163. doi: 10.1071\/HC15033.","DOI":"10.1071\/HC15033"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Colao A, Baldelli R, Marzullo P, et al. Systemic Hypertension and Impaired Glucose Tolerance Are Independently Correlated to the Severity of the Acromegalic Cardiomyopathy 1. J Clin Endocrinol Metab. 2000;85(1):193-199. doi: https:\/\/doi.org\/10.1210\/jcem.85.1.6318","DOI":"10.1210\/jcem.85.1.6318"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Dreval AV, Trigolosova IV, Misnikova IV, et al. Prevalence of diabetes mellitus in patients with acromegaly. Endocr Connect. 2014;3(2):93-98. doi: https:\/\/doi.org\/10.1530\/EC-14-0021","DOI":"10.1530\/EC-14-0021"},{"key":"ref14","unstructured":"Rozhinskaya LYa. Registers and monitoring of diseases of the hypothalamic-pituitary region. Effective pharmacotherapy. Endocrinology. 2014;3(27):46-50. (In Russ.)."},{"key":"ref15","unstructured":"Kovaleva YuA, Ilovayskaya IA, Dreval AV, Starostina EG. Cardiorespiratory disorders in acromegaly of breast cancer. RMZH. 2016;24(1):19-24. (In Russ.)."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Wassenaar MJE, Cazemier M, Biermasz NR, et al. Acromegaly Is Associated with an Increased Prevalence of Colonic Diverticula: A Case-Control Study. J Clin Endocrinol Metab. 2010;95(5):2073-2079. doi: https:\/\/doi.org\/10.1210\/jc.2009-1714","DOI":"10.1210\/jc.2009-1714"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Golkowski F, Krzentowska-Korek A, Baldys-Waligorska A, Hubalewska-Dydejczyk A. Goiter, cardiovascular and metabolic disorders in patients with acromegaly. Endocr Regul. 2011;45(04):191-197. doi: https:\/\/doi.org\/10.4149\/endo_2011_04_191","DOI":"10.4149\/endo_2011_04_191"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Cheng S, Gomez K, Serri O, et al. The Role of Diabetes in Acromegaly Associated Neoplasia. Luque RM, ed. PLoS One. 2015;10(5):e0127276. doi: https:\/\/doi.org\/10.1371\/journal.pone.0127276","DOI":"10.1371\/journal.pone.0127276"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Sekizawa N, Hayakawa E, Tsuchiya K, et al. Acromegaly Associated with Multiple Tumors. Luque RM, ed. Intern Med. 2009;48(15):1273-1278. doi: https:\/\/doi.org\/10.2169\/internalmedicine.48.1916","DOI":"10.2169\/internalmedicine.48.1916"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Varadhan L, Reulen RC, Brown M, Clayton RN. The role of cumulative growth hormone exposure in determining mortality and morbidity in acromegaly: a single centre study. Luque RM, ed. Pituitary. 2016;19(3):251-261. doi: https:\/\/doi.org\/10.1007\/s11102-015-0700-3","DOI":"10.1007\/s11102-015-0700-3"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Wen-Ko C, Szu-Tah C, Feng-Hsuan L, et al. Wp\u0142yw cukrzycy na prze\u017cycie pacjent\u00f3w z akromegali\u0105. Luque RM, ed. Endokrynol Pol. 2016;67(5):501-506. doi: https:\/\/doi.org\/10.5603\/EP.a2016.0031","DOI":"10.5603\/EP.a2016.0031"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Knyazeva OV, Molitvoslovova NN, Rozhinskaya LYa. Frequency of detection of thyroid neoplasms in patients with acromegaly. Clinical and experimental thyroidology. 2015;11(3):34-38. (in Russ.). doi: https:\/\/doi.org\/10.14341\/ket2015334-38","DOI":"10.14341\/ket2015334-38"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Oleynik OV, Molitvoslovova NN. Potential predictors and frequency of thyroid and gastrointestinal neoplasms in patients with acromegaly. Problems of endocrinology. 2015;61(2):4-7. (in Russ.). doi: https:\/\/doi.org\/10.14341\/probl20156124-7","DOI":"10.14341\/probl20156124-7"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Tsoriev TT, White JE. Bone and joint structural abnormalities in acromegalic patients. Problems of endocrinology. 2018;64(2):121-129. (in Russ.). doi: https:\/\/doi.org\/10.14341\/probl9305","DOI":"10.14341\/probl9305"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Reincke M, Petersenn S, Buchfelder M, et al. The German Acromegaly Registry: Description of the Database and Initial Results. Luque RM, ed. Exp Clin Endocrinol Diabetes. 2006;114(09):498-505. doi: https:\/\/doi.org\/10.1055\/s-2006-948313","DOI":"10.1055\/s-2006-948313"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Bex M, Abs R, T\u2019Sjoen G, et al. AcroBel \u2013 the Belgian registry on acromegaly: a survey of the \u2018real-life\u2019 outcome in 418 acromegalic subjects. Luque RM, ed. Eur J Endocrinol. 2007;157(4):399-409. doi: https:\/\/doi.org\/10.1530\/EJE-07-0358","DOI":"10.1530\/EJE-07-0358"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Fernandez A, Karavitaki N, Wass JAH. Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK). Luque RM, ed. Clin Endocrinol (Oxf). 2010;72(3):377-382. doi: https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03667.x","DOI":"10.1111\/j.1365-2265.2009.03667.x"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Mestron A, Webb S, Astorga R, et al. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol. October 2004:439-446. doi: https:\/\/doi.org\/10.1530\/eje.0.1510439","DOI":"10.1530\/eje.0.1510439"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Sesmilo G, Webb S. Twelve years of the Spanish acromegaly registry: a historical view of acromegaly management in Spain. Endocrinol y Nutr. 2010;57(2):39-42. doi: https:\/\/doi.org\/10.1016\/j.endonu.2010.01.003","DOI":"10.1016\/j.endonu.2010.01.003"},{"key":"ref30","unstructured":"Vandeva S, Andreeva M, Orbetsova M, et al. Epidemiological characteristics of acromegaly in the Bulgarian population. Endokrinologya. 2010;13(93):22-25."},{"key":"ref31","unstructured":"Antsiferov MB, Alekseeva TM, Pronin VS. Moscow register of patients with acromegaly: long-term follow-up results. Farmateka. 2016;16:62-66. (in Russ.)."},{"key":"ref32","unstructured":"Pokramovich YuG, Dreval AV. Analysis of data from the register of patients with acromegaly in the Moscow region. RMZH. 2018;26(1-1):17-22. (In Russ.)."},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Belaya JE, Golounina OO, Rozhinskaya LYa, et. al. Epidemiology, clinical manifestations and effectiveness of various methods of treatment of acromegaly according to the unified Russian register of tumors of the hypothalamic-pituitary system. Problems of endocrinology. 2020;66(1):93-103. (In Russ.). https:\/\/doi.org\/10.14341\/probl10333","DOI":"10.14341\/probl10333"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Abreu A, Tovar AP, Castellanos R, et al. Challenges in the diagnosis and management of acromegaly: a focus on comorbidities. Pituitary. 2016;19(4):448-457. doi: https:\/\/doi.org\/10.1007\/s11102-016-0725-2","DOI":"10.1007\/s11102-016-0725-2"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Cannav\u00f2 S, Ferra\u00f9 F, Ragonese M, et al. Increased prevalence of acromegaly in a highly polluted area. Eur J Endocrinol. 2010;163(4):509-513. doi: https:\/\/doi.org\/10.1530\/EJE-10-0465","DOI":"10.1530\/EJE-10-0465"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Burton T, Le Nestour E, Neary M, Ludlam WH. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19(3):262-267. doi: https:\/\/doi.org\/10.1007\/s11102-015-0701-2","DOI":"10.1007\/s11102-015-0701-2"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Melmed S, Bronstein MD, Chanson P, et al. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018;14(9):552-561. doi: https:\/\/doi.org\/10.1038\/s41574-018-0058-5","DOI":"10.1038\/s41574-018-0058-5"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Reid TJ, Post KD, Bruce JN, et al. Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed. Clin Endocrinol (Oxf). 2010;72(2):203-208. doi: https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03626.x","DOI":"10.1111\/j.1365-2265.2009.03626.x"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Knutzen R, Ezzat S. The Cost of Medical Care for the Acromegalic Patient. Neuroendocrinology. 2006;83(3-4):139-144. doi: https:\/\/doi.org\/10.1159\/000095521","DOI":"10.1159\/000095521"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Rosario PW, Calsolari MR. Screening for acromegaly by application of a simple questionnaire evaluating the enlargement of extremities in adult patients seen at primary health care units. Pituitary. 2012;15(2):179-183. doi: https:\/\/doi.org\/10.1007\/s11102-011-0302-7","DOI":"10.1007\/s11102-011-0302-7"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Kosilek RP, Frohner R, W\u00fcrtz RP, et al. Diagnostic use of facial image analysis software in endocrine and genetic disorders: review, current results and future perspectives. Eur J Endocrinol. 2015;173(4):M39-M44. doi: https:\/\/doi.org\/10.1530\/EJE-15-0429","DOI":"10.1530\/EJE-15-0429"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Miller RE, Learned-Miller EG, Trainer P, et al. Early diagnosis of acromegaly: computers vs clinicians. Clin Endocrinol (Oxf). 2011;75(2):226-231. doi: https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04020.x","DOI":"10.1111\/j.1365-2265.2011.04020.x"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Schneider HJ, Kosilek RP, G\u00fcnther M, et al. A Novel Approach to the Detection of Acromegaly: Accuracy of Diagnosis by Automatic Face Classification. J Clin Endocrinol Metab. 2011;96(7):2074-2080. doi: https:\/\/doi.org\/10.1210\/jc.2011-0237","DOI":"10.1210\/jc.2011-0237"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Wagenmakers MAEM, Roerink SHPP, Maal TJJ, et al. Three-dimensional facial analysis in acromegaly: a novel tool to quantify craniofacial characteristics after long-term remission. Pituitary. 2015;18(1):126-134. doi: https:\/\/doi.org\/10.1007\/s11102-014-0565-x","DOI":"10.1007\/s11102-014-0565-x"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Aydin K, Turkyilmaz D, Ozturk B, et al. Voice characteristics of acromegaly. Eur Arch Oto-Rhino-Laryngology. 2013;270(4):1391-1396. doi: https:\/\/doi.org\/10.1007\/s00405-013-2369-4","DOI":"10.1007\/s00405-013-2369-4"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Schneider HJ, Sievers C, Saller B, et al. High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels. Clin Endocrinol (Oxf). 2008;69(3):432-435. doi: https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03221.x","DOI":"10.1111\/j.1365-2265.2008.03221.x"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Rosario PW. Frequency of acromegaly in adults with diabetes or glucose intolerance and estimated prevalence in the general population. Pituitary. 2011;14(3):217-221. doi: https:\/\/doi.org\/10.1007\/s11102-010-0281-0","DOI":"10.1007\/s11102-010-0281-0"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Rosario PW, Calsolari MR. Screening for acromegaly in adult patients not reporting enlargement of the extremities, but with arterial hypertension associated with another comorbidity of the disease. Arq Bras Endocrinol Metabol. 2014;58(8):807-811. doi: https:\/\/doi.org\/10.1590\/0004-2730000003314","DOI":"10.1590\/0004-2730000003314"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Suda K, Fukuoka H, Iguchi G, et al. The prevalence of acromegaly in hospitalized patients with type 2 diabetes. Endocr J. 2015;62(1):53-59. doi: https:\/\/doi.org\/10.1507\/endocrj.EJ14-0254","DOI":"10.1507\/endocrj.EJ14-0254"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Zoicas F, Kleindienst A, Mayr B, et al. Screening for Acromegaly in Patients with Carpal Tunnel Syndrome: A Prospective Study (ACROCARP). Horm Metab Res. 2016;48(07):452-456. doi: https:\/\/doi.org\/10.1055\/s-0042-100913","DOI":"10.1055\/s-0042-100913"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191. doi: https:\/\/doi.org\/10.1001\/jama.2013.281053","DOI":"10.1001\/jama.2013.281053"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Prencipe N, Floriani I, Guaraldi F, et al. ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease. Clin Endocrinol (Oxf). 2016;84(3):380-385. doi: https:\/\/doi.org\/10.1111\/cen.12959","DOI":"10.1111\/cen.12959"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/12699\/9889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T10:01:26Z","timestamp":1613383286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/12699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2,12]]}},"URL":"https:\/\/doi.org\/10.14341\/probl12699","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}