{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T06:45:49Z","timestamp":1746081949572,"version":"3.37.3"},"reference-count":24,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>Backgraund<\/jats:bold>:\u00a0obesity\/overweight in women are often the causes of menstrual dysfunction and infertility.<\/jats:p><jats:p><jats:bold>Aims<\/jats:bold>:\u00a0To identify the association between overweight\/obesity and IVF outcomes.<\/jats:p><jats:p><jats:bold>Materials and methods<\/jats:bold>:\u00a0retrospective study \u2014 data of 1874 patients undergoing IVF in the Endocrinology Research Centre (2012\u20132019) was analyzed. Exclusion criteria: BMI &lt;18.5 kg\/m2, polycystic ovary syndrome, donation of \u00adoocytes, ectopic pregnancy, fertilization with partner\u2019s epididymal\/testicular sperm. The study included 1583 women aged\u00a021\u201345\u00a0years (median 33.0 y.o. [30.0; 37.0], median BMI 23 kg\/m2\u00a0[20.7; 26.2]). Statistical data processing was performed using the\u00a0STATISTICA\u00a0application package (StatSoft). The threshold level of statistical significance is &lt;0.05.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>:\u00a0Patients were divided into 5 groups (gr.): normal body weight (NBW) - 1061 people (ppl.) (gr. 1), overweight \u2014 368 (gr. 2), class I obesity \u2014 117 (gr. 3), class II obesity \u2014 36 (gr. 4), class III obesity \u2014 1 (gr. 5). In each group, the estimated pregnancy rate (PR) and its outcomes, the frequency of lightweight newborns (body weight at birth &lt;2500g), newborns with NBW (2500-3999g), births with a large fetus (\u22654000g) were measured. The PR didn\u2019t differ: 34.6%, 34.5%, 30,7%, 41,7%, respectively, the woman in gr.5 got pregnant. Among 407 (74.4%) singleton pregnancies urgent delivery was registered in 71.91%, 67,57%, 70,83%, 60,0%, gr. 5 \u2014 no\u00a0\u00adinformation. Premature birth: 7,66%, 5,41%, 8,33%, 0%. Spontaneous abortion in the 1st trimester: 18,30%, 25,68%, 20,83%, 40,0%. Spontaneous abortion in the 2nd trimester: 2,13%, 1,35% in gr. 2, 3, 4. Lightweight newborns: 8,81%, 11,36%, 6,25%, 0%. Newborns with NBW: 84,91%, 84,09%, 75,0%, 60,0%. Large-childbirth \u2014 6,29%, 4,55%, 18,75%, 40,0%.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>:\u00a0Correlation analysis of the dependence of PR and its outcomes on the BMI was not revealed (p=0.975 and p=0.469, respectively). Large fetus births were more often detected in obese patients (p=0.0016). A large prospective group is needed to expand the estimated body parameters to the IVF outcomes.<\/jats:p>","DOI":"10.14341\/probl12727","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T10:00:25Z","timestamp":1613383225000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of in vitro fertilization (IVF) infertility treatment outcomes and body weight index in women of reproductive age"],"prefix":"10.14341","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-7348","authenticated-orcid":true,"given":"A. S.","family":"Druzhinina","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-0212","authenticated-orcid":true,"given":"I. I.","family":"Vitiazeva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-8297","authenticated-orcid":true,"given":"D. A.","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 [published correction appears in Lancet. 2014 Aug 30;384(9945):746]. 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