{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:50Z","timestamp":1740173510083,"version":"3.37.3"},"reference-count":28,"publisher":"Endocrinology Research Centre","issue":"3","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Functioning gonadotroph adenomas are rare pituitary tumors secreting one or two gonadotropins (follicle-stimulating hormone (FSH) and\/or luteinizing hormone (LH)), which are hormonally active. In the majority of cases, gonadotroph tumors are endocrinologically \u201csilent\u201d and make up more than a half of non-functioning pituitary adenomas. In this article we describe a rare clinical case of LH\/FSH-secreting pituitary macroadenoma with bitemporal hemianopsia in a 62-year-old man. The patient underwent transnasal transsphenoidal adenomectomy, leading to remission. The distinctive feature of this case is the presence of secondary erythrocytosis due to endogenous hyperandrogenism, which required several blood exfusions to normaliza the level of hematocrit before surgery. It is noteworthy that clinical signs of erythrocytosis were present long before visual impairment. This clinical case demonstrates difficulties in the early diagnosis of functioning gonadotroph adenomas.<\/jats:p>","DOI":"10.14341\/probl12758","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T06:46:08Z","timestamp":1627022768000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of a functioning gonadotroph tumor accompanied by erythrocytosis in an elderly man"],"prefix":"10.14341","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-3599","authenticated-orcid":true,"given":"E. O.","family":"Mamedova","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-0009","authenticated-orcid":true,"given":"L. S.","family":"Selivanova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-8626","authenticated-orcid":true,"given":"K. A.","family":"Potapova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-7791","authenticated-orcid":true,"given":"S. A.","family":"Buryakina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-6099","authenticated-orcid":true,"given":"V. N.","family":"Azizyan","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-4520","authenticated-orcid":true,"given":"A. Yu.","family":"Grigoriev","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-6441","authenticated-orcid":true,"given":"Zh. E.","family":"Belaya","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Ntali G, Capatina C, Grossman A, Karavitaki N. Functioning gonadotroph adenomas. J Clin Endocrinol Metab. 2014;99(12):4423-4433. doi: https:\/\/doi.org\/10.1210\/jc.2014-2362","key":"ref1","DOI":"10.1210\/jc.2014-2362"},{"doi-asserted-by":"crossref","unstructured":"Cote DJ, Smith TR, Sandler CN, et al. Functional gonadotroph adenomas: case series and report of literature. 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Neurosurgery. 2007;61:580-584. doi: https:\/\/doi.org\/10.1227\/01.NEU.0000290906.53685.79","key":"ref5","DOI":"10.1227\/01.NEU.0000290906.53685.79"},{"doi-asserted-by":"crossref","unstructured":"Gryngarten MG, Braslavsky D, Ballerini MG, et al. Spontaneous Ovarian Hyperstimulation Syndrome Caused by a Follicle-Stimulating Hormone-Secreting Pituitary Macroadenoma in an Early Pubertal Girl. Horm Res Paediatr. 2010;73(4):293-298. doi: https:\/\/doi.org\/10.1159\/000284395","key":"ref6","DOI":"10.1159\/000284395"},{"doi-asserted-by":"crossref","unstructured":"Ambrosi B, Bassetti M, Ferrario R, et al. Precocious puberty in a boy with a PRL-, LH- and FSH-secreting pituitary tumour: hormonal and immunocytochemical studies. Acta Endocrinol (Copenh). 1990;122(5):569-576. doi: https:\/\/doi.org\/10.1530\/acta.0.1220569","key":"ref7","DOI":"10.1530\/acta.0.1220569"},{"doi-asserted-by":"crossref","unstructured":"Clemente M, Caracseghi F, Gussinyer M, et al. Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence. Horm Res Paediatr. 2011;75(3):225-230. doi: https:\/\/doi.org\/10.1159\/000322211","key":"ref8","DOI":"10.1159\/000322211"},{"doi-asserted-by":"crossref","unstructured":"Zhao Y, Lian W, Xing B, et al. Functioning gonadotroph adenoma. Chin Med J (Engl). 2019;132(8):1003-1004. doi: https:\/\/doi.org\/10.1097\/CM9.0000000000000184","key":"ref9","DOI":"10.1097\/CM9.0000000000000184"},{"doi-asserted-by":"crossref","unstructured":"Cooper O, Geller JL, Melmed S. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008;4(4):234-238. doi: https:\/\/doi.org\/10.1038\/ncpendmet0758","key":"ref10","DOI":"10.1038\/ncpendmet0758"},{"doi-asserted-by":"crossref","unstructured":"Halupczok J, Bidzi\u0144ska-Speichert B, Lenarcik-Kabza A, et al. Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman. Gynecol Endocrinol. 2014;30(11):774-777. doi: https:\/\/doi.org\/10.3109\/09513590.2014.934668","key":"ref11","DOI":"10.3109\/09513590.2014.934668"},{"doi-asserted-by":"crossref","unstructured":"Hirano M, Wada-Hiraike O, Miyamamoto Y, et al. A case of functioning gonadotroph adenoma in a reproductive aged woman. Endocr J. 2019;66(7):653-656. doi: https:\/\/doi.org\/10.1507\/endocrj.EJ19-0066","key":"ref12","DOI":"10.1507\/endocrj.EJ19-0066"},{"doi-asserted-by":"crossref","unstructured":"Broughton C, Mears J, Williams A, Lonnen K. A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis. Endocrinol Diabetes Metab Case Reports. 2018;2018. doi: https:\/\/doi.org\/10.1530\/EDM-18-0123","key":"ref13","DOI":"10.1530\/EDM-18-0123"},{"doi-asserted-by":"crossref","unstructured":"Graillon T, Castinetti F, Chabert-Orsini V, et al. 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