{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:47:33Z","timestamp":1774925253902,"version":"3.50.1"},"reference-count":19,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Multiple lesions of the parathyroid glands (PTG) in primary hyperparathyroidism (PHPT) can be sporadic or develop as part of hereditary syndromes, manifesting at young age. There the description of a severe sporadic PHPT with big parathyroid neoplasms in the young patient is presented. Clinical data made it possible to suspect MEN-1 syndrome or parathyroid carcinomas; however, mutations CDKN, CDC73, MEN1 were excluded. The patient underwent removal of three identified tumors: benign adenomas of the left PTG and hyperplasia of the right one. Postoperative hypocalcemia and severe hungry bone syndrome required the administration of vitamin D and calcium carbonate preparations. However, a year after the operation, a \u00abmild\u00bb recurrent disease was confirmed. Taking into account the patient\u2019s refusal to reoperation and a significant improvement of the target organs state, active observation was continued. The patient needs further careful dynamic monitoring by specialists in order to timely identify indications for repeated surgical treatment to improve the life quality and span.<\/jats:p>","DOI":"10.14341\/probl12798","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:11:47Z","timestamp":1641978707000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":5,"title":["Sporadic primary hyperparathyroidism with multiple parathyroid adenomas"],"prefix":"10.14341","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-5846","authenticated-orcid":true,"given":"E. E.","family":"Bibik","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-062X","authenticated-orcid":true,"given":"A. K.","family":"Eremkina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-4665","authenticated-orcid":true,"given":"O. A.","family":"Knyazeva","sequence":"additional","affiliation":[{"name":"\u201cAltamed plus\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-9742","authenticated-orcid":true,"given":"N. G.","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mamedova EO, Mokrysheva NG, Rozhinskaia LYa. Characteristics of primary hyperparathyroidism in young patients. Problems of endocrinology. 2018;64(3):163-169. (in Russ.) doi:10.14341\/probl9399","DOI":"10.14341\/probl9399"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Barczy\u0144ski M, Br\u00e4nstr\u00f6m R, Dionigi G, Mihai R. Sporadic multiple parathyroid gland disease--a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbeck\u2019s Arch Surg. 2015;400(8):887-905. doi:10.1007\/s00423-015-1348-1","DOI":"10.1007\/s00423-015-1348-1"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Venkatachala S, Kumar SR, Premkumar S. Double adenoma of the parathyroid: reinforcing the existence of this entity. Indian J Pathol Microbiol. 2013;56(3):328-329. doi:10.4103\/0377-4929.120420","DOI":"10.4103\/0377-4929.120420"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Cupisti K, Raffel A, Dotzenrath C, Krausch M, R\u00f6her H-D, Schulte K-M. Primary Hyperparathyroidism in the Young Age Group: Particularities of Diagnostic and Therapeutic Schemes. 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