{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:09:42Z","timestamp":1763748582862,"version":"3.37.3"},"reference-count":39,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>B<\/jats:bold><jats:bold>ACKGROUND:<\/jats:bold><jats:bold> <\/jats:bold>Melatonin is the main hormone of the pineal gland. By regulating circadian rhythms and being an immune regulator and antioxidant, this hormone takes part in the work of the ovaries: its high concentrations block apoptosis and neutralize reactive oxygen species involved in folliculogenesis, ovulation, egg maturation and corpus luteum formation.<\/jats:p><jats:p><jats:bold>AIM: <\/jats:bold>To study melatonin status and its relationship with menstrual dysfunction and sleep disorders in obese women of reproductive age.<\/jats:p><jats:p><jats:bold>MA<\/jats:bold><jats:bold>TERIALS<\/jats:bold><jats:bold> <\/jats:bold><jats:bold>AND METHODS<jats:italic>. <\/jats:italic><\/jats:bold>In a one-stage comparative study, women 18-35 years old took part: 30 patients with obesity and menstrual disorders of an inorganic nature and 30 healthy women in the comparison group with normal weight and regular menstrual cycle. All participants underwent a questionnaire to identify somnological disorders, and the level of melatonin in saliva and 6-sulfatoxymelatonin in urine was also investigated.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold><jats:bold> <\/jats:bold>In the group of patients with obesity (n=30), various sleep disorders were encountered in 47% of cases (p=0.003), including more often obstructive sleep apnea syndrome was recorded (30% of cases), and a correlation was found between the indicators of the questionnaire survey of subjective sleep characteristics and body mass index of patients (r=0.450, p=0.030) compared with a group of healthy women with normal weight (n=30). In the main group, the level of melatonin in saliva was statistically significantly lower than in the control: median 12.6 pg \/ ml and 25.5 pg \/ ml, respectively (p=0.008), the same pattern was recorded for 6-sulfatoxymelatonin: 14, 72 pg \/ ml and 31.12 pg \/ ml, respectively.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold><jats:bold> <\/jats:bold>Patients with obesity and menstrual dysfunction are more likely to suffer from various sleep disorders and have lower levels of melatonin in saliva and 6-sulfatoxymelatonin in urine.<\/jats:p>","DOI":"10.14341\/probl12849","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T16:05:35Z","timestamp":1646755535000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":2,"title":["Melatonin status in obese patients with ovarian dysfunction at reproductive age"],"prefix":"10.14341","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8425-0020","authenticated-orcid":true,"given":"E. 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J Pineal Res. 2014;56(4):382-97. https:\/\/doi.org\/10.1111\/jpi.12133","key":"ref2","DOI":"10.1111\/jpi.12133"},{"doi-asserted-by":"crossref","unstructured":"Pandi-Perumal SR, BaHammam AS, Ojike NI, et al. Melatonin and Human Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 2017;22(2):122-132. https:\/\/doi.org\/10.1177\/1074248416660622","key":"ref3","DOI":"10.1177\/1074248416660622"},{"doi-asserted-by":"crossref","unstructured":"Szewczyk-Golec K, Wo\u017aniak A, Reiter RJ. Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity. J Pineal Res. 2015;59(3):277-91. https:\/\/doi.org\/10.1111\/jpi.12257","key":"ref4","DOI":"10.1111\/jpi.12257"},{"doi-asserted-by":"crossref","unstructured":"Rhee YH, Ahn JC. Melatonin attenuated adipogenesis through reduction of the CCAAT\/enhancer binding protein beta by regulating the glycogen synthase 3 beta in human mesenchymal stem cells. J Physiol Biochem. 2016;72(2):145-55. https:\/\/doi.org\/10.1007\/s13105-015-0463-3","key":"ref5","DOI":"10.1007\/s13105-015-0463-3"},{"doi-asserted-by":"crossref","unstructured":"Jimen\u00e9z-Aranda A, Fern\u00e1ndez-V\u00e1zquez G, Mohammad A-Serrano M, et al. Melatonin improves mitochondrial function in inguinal white adipose tissue of Z\u00fccker diabetic fatty rats. J Pineal Res. 2014;57(1):103-9. https:\/\/doi.org\/10.1111\/jpi.12147","key":"ref6","DOI":"10.1111\/jpi.12147"},{"doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez V\u00e1zquez G, Reiter RJ, Agil A. Melatonin increases brown adipose tissue mass and function in Z\u00fccker diabetic fatty rats: implications for obesity control. J Pineal Res. 2018;64(4):e12472. https:\/\/doi.org\/10.1111\/jpi.12472.","key":"ref7","DOI":"10.1111\/jpi.12472"},{"doi-asserted-by":"crossref","unstructured":"Xu P, Wang J, Hong F, et al. Melatonin prevents obesity through modulation of gut microbiota in mice. J Pineal Res. 2017;62(4). https:\/\/doi.org\/10.1111\/jpi.12399.","key":"ref8","DOI":"10.1111\/jpi.12399"},{"doi-asserted-by":"crossref","unstructured":"Ireland KE, Maloyan A, Myatt L. Melatonin Improves Mitochondrial Respiration in Syncytiotrophoblasts From Placentas of Obese Women. Reprod Sci. 2018;25(1):120-130. https:\/\/doi.org\/10.1177\/1933719117704908","key":"ref9","DOI":"10.1177\/1933719117704908"},{"doi-asserted-by":"crossref","unstructured":"Peschke E, B\u00e4hr I, M\u00fchlbauer E. Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon. Int J Mol Sci. 2013;14(4):6981-7015. https:\/\/doi.org\/10.3390\/ijms14046981","key":"ref10","DOI":"10.3390\/ijms14046981"},{"doi-asserted-by":"crossref","unstructured":"Qian J, Dalla Man C, Morris CJ, et al. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. 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Cell Mol Life Sci. 2017;74(21):3863-3881. https:\/\/doi.org\/10.1007\/s00018-017-2609-7","key":"ref14","DOI":"10.1007\/s00018-017-2609-7"},{"doi-asserted-by":"crossref","unstructured":"Genario R, Morello E, Bueno AA, Santos HO. The usefulness of melatonin in the field of obstetrics and gynecology. Pharmacol Res. 2019;147:104337. https:\/\/doi.org\/10.1016\/j.phrs.2019.104337","key":"ref15","DOI":"10.1016\/j.phrs.2019.104337"},{"doi-asserted-by":"crossref","unstructured":"Fernandez B, Malde JL, Montero A, Acu\u00f1a D. Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. J Steroid Biochem. 1990;35(2):257-62. https:\/\/doi.org\/10.1016\/0022-4731(90)90282-w","key":"ref16","DOI":"10.1016\/0022-4731(90)90282-W"},{"unstructured":"Ma M, Chen XY, Li B, Li XT. Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1. Am J Transl Res. 2017;9(4):1580-1602.","key":"ref17"},{"doi-asserted-by":"crossref","unstructured":"Tamura H, Takasaki A, Taketani T, et al. Melatonin as a free radical scavenger in the ovarian follicle. Endocr J. 2013;60(1):1-13. https:\/\/doi.org\/10.1507\/endocrj.ej12-0263","key":"ref18","DOI":"10.1507\/endocrj.EJ12-0263"},{"doi-asserted-by":"crossref","unstructured":"Tan DX, Manchester LC, Esteban-Zubero E, et al. Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism. Molecules. 2015;20(10):18886-906. https:\/\/doi.org\/10.3390\/molecules201018886","key":"ref19","DOI":"10.3390\/molecules201018886"},{"doi-asserted-by":"crossref","unstructured":"Nakamura Y, Tamura H, Takayama H, Kato H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil Steril. 2003;80(4):1012-6. https:\/\/doi.org\/10.1016\/s0015-0282(03)01008-2","key":"ref20","DOI":"10.1016\/S0015-0282(03)01008-2"},{"doi-asserted-by":"crossref","unstructured":"Teixeira AAC, Sim\u00f6es MdJ, Teixeira VW, Soares J\u00fanior JM. Evaluation of the implantation in pinealectomized and\/or submitted to the constant illumination rats. Int. J. Morphol. 2004;22:189\u2013194.","key":"ref21","DOI":"10.4067\/S0717-95022004000300003"},{"doi-asserted-by":"crossref","unstructured":"Song C, Peng W, Yin S, et al. Melatonin improves ageinduced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci Rep. 2016;6:35165. https:\/\/doi.org\/10.1038\/srep35165","key":"ref22","DOI":"10.1038\/srep35165"},{"doi-asserted-by":"crossref","unstructured":"Tagliaferri V, Romualdi D, Scarinci E, et al. Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study. Reprod Sci. 2018;25(2):269-275. https:\/\/doi.org\/10.1177\/1933719117711262","key":"ref23","DOI":"10.1177\/1933719117711262"},{"doi-asserted-by":"crossref","unstructured":"Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesityassociated disorders: A review of physiological mechanisms and clinical applications. Pharmacol Res. 2021;163:105254. https:\/\/doi.org\/10.1016\/j.phrs.2020.105254","key":"ref24","DOI":"10.1016\/j.phrs.2020.105254"},{"doi-asserted-by":"crossref","unstructured":"Levin YaI, Eligulashvili TS, Posokhov SI, et al. Farmakoterapiya insomnii: rol\u2019 Imovana. V kn. Rasstroistva sna. \u0420od red. Yu.A. Aleksandrovskogo i A.M. Veina. Sankt-Peterburg: Meditsinskoe informatsionnoe agenstvo, 1995. S. 56-61 (in Russian).","key":"ref25","DOI":"10.1016\/0254-0584(94)01445-M"},{"doi-asserted-by":"crossref","unstructured":"Summa KC, Turek FW. Chronobiology and obesity: Interactions between circadian rhythms and energy regulation. Adv Nutr. 2014;5(3):312S-9S. https:\/\/doi.org\/10.3945\/an.113.005132","key":"ref26","DOI":"10.3945\/an.113.005132"},{"doi-asserted-by":"crossref","unstructured":"Corbal\u00e1n-Tutau D, Madrid JA, Nicol\u00e1s F, Garaulet M. Daily profile in two circadian markers \u00abmelatonin and cortisol\u00bb and associations with metabolic syndrome components. Physiol Behav. 2014;123:231-5. https:\/\/doi.org\/10.1016\/j.physbeh.2012.06.005","key":"ref27","DOI":"10.1016\/j.physbeh.2012.06.005"},{"doi-asserted-by":"crossref","unstructured":"Reiter RJ, Tan DX, Korkmaz A, Ma S. Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. Ann Med. 2012;44(6):564-77. https:\/\/doi.org\/10.3109\/07853890.2011.586365","key":"ref28","DOI":"10.3109\/07853890.2011.586365"},{"doi-asserted-by":"crossref","unstructured":"Taheri S, Lin L, Austin D, et al. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1(3):e62. https:\/\/doi.org\/10.1371\/journal.pmed.0010062","key":"ref29","DOI":"10.1371\/journal.pmed.0010062"},{"doi-asserted-by":"crossref","unstructured":"Willis SK, Hatch EE, Wise LA. Sleep and female reproduction. Curr Opin Obstet Gynecol. 2019;31(4):222-227. https:\/\/doi.org\/10.1097\/GCO.0000000000000554","key":"ref30","DOI":"10.1097\/GCO.0000000000000554"},{"doi-asserted-by":"crossref","unstructured":"Liu Y, Wheaton AG, Chapman DP, et al. Prevalence of Healthy Sleep Duration among Adults \u2014 United States, 2014. MMWR Morb Mortal Wkly Rep. 2016;65(6):137-41. https:\/\/doi.org\/10.15585\/mmwr.mm6506a1","key":"ref31","DOI":"10.15585\/mmwr.mm6506a1"},{"doi-asserted-by":"crossref","unstructured":"Wang Y, Gu F, Deng M, et al. Rotating shift work and menstrual characteristics in a cohort of Chinese nurses. BMC Womens Health. 2016;16:24. https:\/\/doi.org\/10.1186\/s12905-016-0301-y","key":"ref32","DOI":"10.1186\/s12905-016-0301-y"},{"doi-asserted-by":"crossref","unstructured":"Kang W, Jang KH, Lim HM, et al. The menstrual cycle associated with insomnia in newly employed nurses performing shift work: a 12-month follow-up study. Int Arch Occup Environ Health. 2019;92(2):227-235. https:\/\/doi.org\/10.1007\/s00420-018-1371-y","key":"ref33","DOI":"10.1007\/s00420-018-1371-y"},{"doi-asserted-by":"crossref","unstructured":"Goldstein CA, Lanham MS, Smith YR, O\u2019Brien LM. Sleep in women undergoing in vitro fertilization: a pilot study. Sleep Med. 2017;32:105-113. https:\/\/doi.org\/10.1016\/j.sleep.2016.12.007","key":"ref34","DOI":"10.1016\/j.sleep.2016.12.007"},{"doi-asserted-by":"crossref","unstructured":"Wang ID, Liu YL, Peng CK, et al. Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. Sleep. 2018;41(1). https:\/\/doi.org\/10.1093\/sleep\/zsx186","key":"ref35","DOI":"10.1093\/sleep\/zsx186"},{"doi-asserted-by":"crossref","unstructured":"Willis SK, Hatch EE, Wesselink AK, et al. Female sleep patterns, shift work, and fecundability in a North American preconception cohort study. Fertil Steril. 2019;111(6):1201-1210.e1. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.01.037","key":"ref36","DOI":"10.1016\/j.fertnstert.2019.01.037"},{"doi-asserted-by":"crossref","unstructured":"Sturgeon SR, Doherty A, Reeves KW, et al. Urinary levels of melatonin and risk of postmenopausal breast cancer: women\u2019s health initiative observational cohort. Cancer Epidemiol Biomarkers Prev. 2014;23(4):629-37. https:\/\/doi.org\/10.1158\/1055-9965.EPI-13-1028","key":"ref37","DOI":"10.1158\/1055-9965.EPI-13-1028"},{"doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Acebo I, Dierssen-Sotos T, Papantoniou K, et al. Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women. Chronobiol Int. 2015;32(1):128-35. https:\/\/doi.org\/10.3109\/07420528.2014.958494","key":"ref38","DOI":"10.3109\/07420528.2014.958494"},{"doi-asserted-by":"crossref","unstructured":"Luboshitzky R, Qupti G, Ishay A, et al. Increased 6-sulfatoxymelatonin excretion in women with polycystic ovary syndrome. 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