{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:55:02Z","timestamp":1792533302604,"version":"4.5.0"},"reference-count":12,"publisher":"Endocrinology Research Centre","issue":"3","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>BACKGROUND: Self-monitoring of blood glucose (SMBG) with glucometers provides only a snapshot of the glycemic profile and is accompanied by significant psychological discomfort and pain, especially in children. Flash Glucose Monitoring System \u2014 FreeStyle Libre (FSL) overcomes many of the barriers associated with glucose measurement and improves metabolic control.<\/jats:p><jats:p>AIM: To evaluate the efficacy of FSL in children with type 1 diabetes mellitus (T1DM) in terms of glycemic control, episodes of severe hypoglycemia (SH) and diabetic ketoacidosis (DKA).<\/jats:p><jats:p>MATERIALS AND METHODS. A multicenter, prospective, observational study in real clinical practice was carried out. A total of 469 subjects (258 boys and 211 girls) aged 4\u201318 were included in the study. The median age was 11.3 (8.4\u201314.6) years, duration of T1DM \u2014 4.2 (2.1\u20137.1) years. After FSL start, patient was followed up for 6 months.<\/jats:p><jats:p>RESULTS: After 3 and 6 months of FSL use, HbA1c significantly decreased from 7.4% to 7.1% and 7.2%, respectively (p&lt;0.001). The number of children with HbA1c &gt;&lt;7.5% increased from 51% to 60% and 58% at 3 and 6 months, respectively (p&gt;&lt;0.001). The incidence of DKA and SH, as well as the proportion of patients experiencing at least one episode of DKA and SH, were significantly reduced after 6 months of FSL use compared with baseline (p&gt;&lt;0.001).<\/jats:p><jats:p>CONCLUSION: The Study demonstrated a significant improvement in metabolic control in children with T1DM 6 months after FSL start: decrease in HbA1c, accompanied by reduction in incidence of DKA and SH.<\/jats:p>","DOI":"10.14341\/probl12877","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T06:38:39Z","timestamp":1657953519000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of FreeStyle Libre in pediatric t1dm: improved glycemic control, reduction in diabetic ketoacidosis and severe hypoglycemia"],"prefix":"10.14341","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-8546","authenticated-orcid":true,"given":"D. N.","family":"Laptev","sequence":"first","affiliation":[{"name":"National Medical Research Center for Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-5732","authenticated-orcid":true,"given":"O. B.","family":"Bezlepkina","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-1245","authenticated-orcid":true,"given":"E. S.","family":"Demina","sequence":"additional","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-0867","authenticated-orcid":true,"given":"O. A.","family":"Malievskiy","sequence":"additional","affiliation":[{"name":"Bashkir State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-0785","authenticated-orcid":true,"given":"I. L.","family":"Nikitina","sequence":"additional","affiliation":[{"name":"National Medical Research Center n.a. V. A. Almazov"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-4842","authenticated-orcid":true,"given":"I. G.","family":"Samoilova","sequence":"additional","affiliation":[{"name":"Siberian State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-4627","authenticated-orcid":true,"given":"V. A.","family":"Peterkova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5458","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Dedov II, Shestakova MV, Mayorov AYu, et al. Standards of specialized diabetes care. Diabetes Mellitus. 2019;22(S1):1-144 (In Russ.). doi: https:\/\/doi.org\/10.14341\/DM221S1.","DOI":"10.14341\/DM221S1"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Peterkova VA, Shestakova MV, Bezlepkina OB, et al. Diabetes mellitus type 1 in childhood. Diabetes mellitus. 2020;23(1S):4-40. (In Russ.). doi: https:\/\/doi.org\/10.14341\/DM12504.","DOI":"10.14341\/DM12504"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Dedov II, Shestakova MV, Mayorov AY, et al. Diabetes mellitus type 1 in adults. Diabetes mellitus. 2020;23(1S):42-114. (In Russ.) doi: https:\/\/doi.org\/10.14341\/DM12505.","DOI":"10.14341\/DM12286"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"DiMeglio LA, Acerini CL, Codner E, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes. Pediatr Diabetes. 2018;19:105-114. doi: https:\/\/doi.org\/10.1111\/pedi.12737","DOI":"10.1111\/pedi.12737"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Campbell FM, Murphy NP, Stewart C, et al. Outcomes of using flash glucose monitoring technology by children and young people with type 1 diabetes in a single arm study. Pediatr Diabetes. 2018;19(7):1294-1301. doi: https:\/\/doi.org\/10.1111\/pedi.12735","DOI":"10.1111\/pedi.12735"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tauschmann M, Hermann JM, Freiberg C, et al. 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Pediatr Int. 2021;63(2):154-159. doi: https:\/\/doi.org\/10.1111\/ped.14412","DOI":"10.1111\/ped.14412"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Messaaoui A, Tenoutasse S, Crenier L. Flash Glucose Monitoring Accepted in Daily Life of Children and Adolescents with Type 1 Diabetes and Reduction of Severe Hypoglycemia in Real-Life Use. Diabetes Technol Ther. 2019;21(6):329-335. doi: https:\/\/doi.org\/10.1089\/dia.2018.0339","DOI":"10.1089\/dia.2018.0339"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Deeb A, Yousef H, Al Qahtani N, et al. Novel ambulatory glucosesensing technology improves hypoglycemia detection and patient monitoring adherence in children and adolescents with type 1 diabetes. J Diabetes Metab Disord. 2019;18(1):1-6. doi: https:\/\/doi.org\/10.1007\/s40200-018-0351-9","DOI":"10.1007\/s40200-018-0351-9"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Al Hayek AA, Robert AA, Al Dawish MA. Evaluation of FreeStyle Libre Flash Glucose Monitoring System on Glycemic Control, HealthRelated Quality of Life, and Fear of Hypoglycemia in Patients with Type 1 Diabetes. Clin Med Insights Endocrinol Diabetes. 2017;10. doi: https:\/\/doi.org\/10.1177\/1179551417746957","DOI":"10.1177\/1179551417746957"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Vergier J, Samper M, Dalla-Vale F, et al. Evaluation of flash glucose monitoring after long-term use: A pediatric survey. Prim Care Diabetes. 2019;13(1):63-70. doi: https:\/\/doi.org\/10.1016\/j.pcd.2018.08.004","DOI":"10.1016\/j.pcd.2018.08.004"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/12877\/10259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T06:39:03Z","timestamp":1657953543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/12877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,15]]}},"URL":"https:\/\/doi.org\/10.14341\/probl12877","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,22]]}}}