{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:53Z","timestamp":1740173513573,"version":"3.37.3"},"reference-count":19,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>BACKGROUND<\/jats:bold>: The issues of monitoring the effectiveness of iodine deficiency prevention programs are an important component in the process of iodine elimination. Neonatal thyrotropin (TSH) has been used as a criterion for the severity of iodine deficiency since 1994, however, the question of the \u201ccut-off point\u201d of the neonatal TSH level has been widely discussed in the recent literature.<jats:bold>AIM<\/jats:bold>: Evaluate the criterion for neonatal hyperthyroidism above 5 mIU\/l from the perspective of monitoring iodine deficiency and establish a \u00abcut-off point\u00bb on the model of healthy pregnant women with adequate iodine status.<jats:bold>MATERIALS AND METHODS<\/jats:bold>: A prospective study was conducted in a population of pregnant women in the city of Tyumen, with the formation of observation groups according to the level of iodine excretion in the urine \u2014 the main group (with adequate iodine status throughout the entire gestation period) and the comparison group (women with iodine levels less than 150 \u03bcg\/l). The results of neonatal screening for congenital hypothyroidism in children of women participating in the study were evaluated. The frequency of neonatal TSH above 5mIU\/l was assessed in the observation groups. ROC-analysis was performed and a \u00abcut-off point\u00bb of the level of neonatal TSH was established as an indicator of iodine deficiency.<jats:bold>RESULTS<\/jats:bold>: The median urinary iodine concentration in the population of pregnant women in Tyumen was 159.05 \u03bcg\/l, the incidence of goiter was 0.38%, the incidence of neonatal hyperthyroidism above 5 mIU\/l was 2.88%, which characterizes adequate iodine intake in the pregnant population women. The frequency of neonatal TSH above 5 mIU\/l in newborns from women from the main group was 1.47%, and in the comparison group \u2014 9.3% (p = 0.076). ROC analysis revealed a threshold value of neonatal TSH of 2.77 mIU\/l at the cut-off point, which corresponded to the highest value of the Youden index. Urinary iodine concentrations greater than 150 \u03bcg\/l were predicted for nTSH values below this value.<jats:bold>CONCLUSION<\/jats:bold>: Analysis of databases of neonatal screening for congenital hypothyroidism makes it possible to effectively, quickly and at minimal cost annually assess the iodine status in the population. The established \u00abcut-off point\u00bb of neonatal TSH in the model of healthy pregnant women with adequate iodine intake in our work is 2.77 mIU\/l, the absence of statistically significant differences in the incidence of neonatal hyperthyroidism above 5 mIU\/l from women with different iodine status during pregnancy indicate the need to revise the existing threshold of 5 mIU\/l and may be an incentive to conduct large-scale studies in regions with different iodine supply.<\/jats:p>","DOI":"10.14341\/probl12892","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T12:20:40Z","timestamp":1674735640000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal thyrotropin - indicatior of monitoring of iodine deficiency severity. What\u2019s level is considered a \u00abcutoff point\u00bb?"],"prefix":"10.14341","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-8075","authenticated-orcid":true,"given":"L. A.","family":"Suplotova","sequence":"first","affiliation":[{"name":"Tyumen State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-0289","authenticated-orcid":true,"given":"O. B.","family":"Makarova","sequence":"additional","affiliation":[{"name":"Tyumen State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8702","authenticated-orcid":true,"given":"E. A.","family":"Troshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2022,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Barnabishvilli N, Gerasimov GA, Azikuri T. The results of neonatal TSH screening do not agree with indicators of the optimal iodine status of pregnant women in the Republic of Georgia. Clinical and experimental thyroidology. 2018;14(2):81-85. (In Russ.). doi: https:\/\/doi.org\/10.14341\/ket9777","DOI":"10.14341\/ket9777"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Vandevijvere S, Coucke W, Vanderpas J, et al. Neonatal thyroid stimulating hormone concentrations in Belgium: A useful indicator for detecting mild iodine deficiency? 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(In Russ.). doi: https:\/\/doi.org\/10.14341\/ket12525","DOI":"10.14341\/ket12525"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/12892\/10375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T12:20:55Z","timestamp":1674735655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/12892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,31]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,1,20]]}},"URL":"https:\/\/doi.org\/10.14341\/probl12892","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"type":"electronic","value":"2308-1430"},{"type":"print","value":"0375-9660"}],"subject":[],"published":{"date-parts":[[2022,7,31]]}}}