{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:28:03Z","timestamp":1753522083814,"version":"3.37.3"},"reference-count":19,"publisher":"Endocrinology Research Centre","issue":"5","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Hypopituitarism is a state of complete or partial deficiency of pituitary hormones, including adrenal insufficiency, hypothyroidism, hypogonadism, growth hormone deficiency, and, rarely, diabetes insipidus.<\/jats:p><jats:p>The article describes a clinical case of hypopituitarism due to a pituitary tumor in a postmenopausal woman. Difficulties in diagnosing hypopituitarism were due to a history of primary hypothyroidism. The first identified component of panhypopituitarism in the patient, (central hypothyroidism) had previously been seen as laboratory indications of medication-induced hyperthyroidism.<\/jats:p><jats:p>The non-specific nature of the clinical symptoms, as well as a relatively rare combination of endocrine diseases, led to a long examination period and delayed diagnosis of the pituitary tumor.<\/jats:p><jats:p>Whether the development of hypopituitarism in a patient with a nonfunctional pituitary tumor is an indication for transsphenoidal pituitary surgery remains a controversial issue. The decision for surgery is made taking into account the characteristics of the course of the disease in a particular patient. In this clinical case, a conservative tactic was chosen with hormone replacement therapy for glucocorticoid and thyroid deficiency.<\/jats:p>","DOI":"10.14341\/probl13128","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T20:09:50Z","timestamp":1667851790000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma"],"prefix":"10.14341","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-1692","authenticated-orcid":true,"given":"E. G.","family":"Ryzhkova","sequence":"first","affiliation":[{"name":"Central Clinical Hospital of the Management Affair of President Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-7060","authenticated-orcid":true,"given":"D. O.","family":"Ladygina","sequence":"additional","affiliation":[{"name":"Central Clinical Hospital of the Management Affair of President Russian Federation; Fomin Women\u2019s Health Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Fleseriu M, Hashim IA, Karavitaki N, et al. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888-3921. doi: https:\/\/doi.org\/10.1210\/jc.2016-2118","DOI":"10.1210\/jc.2016-2118"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Higham CE, Johannsson G, Shalet SM. Hypopituitarism. Lancet. 2016;388(10058):2403-2415. doi: https:\/\/doi.org\/10.1016\/S0140-6736(16)30053-8","DOI":"10.1016\/S0140-6736(16)30053-8"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Regal M, P\u00e1ramo C, Sierra SM, Garcia-Mayor RV. Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clin Endocrinol (Oxf). 2001;55(6):735-740. doi: https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01406.x","DOI":"10.1046\/j.1365-2265.2001.01406.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Pekic S, Popovic V. Diagnosis of endocrine disease: Expanding the cause of hypopituitarism. Eur J Endocrinol. 2017;176(6):R269-R282. doi: https:\/\/doi.org\/10.1530\/EJE-16-1065","DOI":"10.1530\/EJE-16-1065"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kim SY. Diagnosis and Treatment of Hypopituitarism. Endocrinol Metab (Seoul). 2015;30(4):443-455. doi: https:\/\/doi.org\/10.3803\/EnM.2015.30.4.443","DOI":"10.3803\/EnM.2015.30.4.443"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Araujo-Castro M, Berrocal VR, Pascual-Corrales E. Pituitary tumors: epidemiology and clinical presentation spectrum. Hormones (Athens). 2020;19(2):145-155. doi: https:\/\/doi.org\/10.1007\/s42000-019-00168-8","DOI":"10.1007\/s42000-019-00168-8"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Persani L, Cangiano B, Bonomi M. The diagnosis and management of central hypothyroidism in 2018. Endocr Connect. 2019;8(2):R44-R54. doi: https:\/\/doi.org\/10.1530\/EC-18-0515","DOI":"10.1530\/EC-18-0515"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Persani L, Brabant G, Dattani M, et al. 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism. Eur Thyroid J. 2018;7(5):225-237. doi: https:\/\/doi.org\/10.1159\/000491388","DOI":"10.1159\/000491388"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Fadeev VV, Morgunova TB, Melnichenko GA, et al. Draft of the clinical recommendations for diagnosis and treatment of hypothyroidism. Clinical and experimental thyroidology. 2021;17(1):4-13. (In Russ.). doi: https:\/\/doi.org\/10.14341\/ket12702","DOI":"10.14341\/ket12702"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. 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Pituitary incidentalomas: the clinical picture, diagnostics, differential diagnostics, and methods of treatment. Problems of Endocrinology. 2015;61(3):57-68. (In Russ.). doi: https:\/\/doi.org\/10.14341\/probl201561357-68","DOI":"10.14341\/probl201561357-68"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Huang W, Molitch ME. Management of nonfunctioning pituitary adenomas (NFAs): observation. Pituitary. 2018;21(2):162-167. doi: https:\/\/doi.org\/10.1007\/s11102-017-0856-0","DOI":"10.1007\/s11102-017-0856-0"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Orija IB, Weil RJ, Hamrahian AH. Pituitary incidentaloma. Best Pract Res Clin Endocrinol Metab. 2012;26(1):47-68. doi: https:\/\/doi.org\/10.1016\/j.beem.2011.07.003","DOI":"10.1016\/j.beem.2011.07.003"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Freda PU, Beckers AM, Katznelson L, et al. Pituitary incidentaloma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(4):894-904. doi: https:\/\/doi.org\/10.1210\/jc.2010-1048","DOI":"10.1210\/jc.2010-1048"},{"key":"ref17","unstructured":"Stalldecker G, Ballarino C, Diez S, Mallea-Gil MS. Adenomas hipofisarios en pacientes a\u00f1osos [Pituitary adenomas in elderly patients]. Medicina (B Aires). 2019;79(3):191-196."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Flores-Martinez \u00c1, Venegas-Moreno E, Dios E, et al. Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features. J Clin Med. 2020;9(9):3052. doi: https:\/\/doi.org\/10.3390\/jcm9093052","DOI":"10.3390\/jcm9093052"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Giraldi EA, Ioachimescu AG. The Role of Dopamine Agonists in Pituitary Adenomas. 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