{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:57Z","timestamp":1790283657280,"version":"4.1.0"},"reference-count":18,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Cyclic Cushing\u2019s syndrome is a pathological condition characterized by alternating periods of excessive cortisol secretion with corresponding clinical manifestations and periods of spontaneous remission of the disease.<\/jats:p>\n                  <jats:p>To diagnose Cyclic Cushing\u2019s syndrome it is necessary to record at least three episodes of excessive cortisol secretion alternating with periods of normalization of its production.<\/jats:p>\n                  <jats:p>In most cases, this pathology is diagnosed in patients with ACTH-secreting pituitary tumor, however, there are rare cases of cyclic hypercorticism with ectopic ACTH secretion by tumors of different localization and without verification of pathological hormonal secretion focus. In addition, cyclic hyperproduction of cortisol can be also observed in ACTH-independent Cushing\u2019s syndrome associated with the presence of corticosteroma or adrenal hyperplasia. The exact causes and mechanisms of the cyclic hypercorticism are currently insufficiently studied.<\/jats:p>\n                  <jats:p>Due to the atypical course of the disease, the unpredictability of the occurrence of a new \u00abcycle\u00bb, the variability of its duration and manifestations (not only in different patients, but also in the same patient), verification of the diagnosis and determination of treatment tactics may be difficult in the daily practice of specialists, and the prevalence of this condition can be undervalued.<\/jats:p>","DOI":"10.14341\/probl13140","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:58:30Z","timestamp":1677459510000},"page":"8-14","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":3,"title":["Cyclic Cushing\u2019s syndrome: difficulties of diagnostic search and choice of treatment tactics. A clinical case"],"prefix":"10.14341","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-4619","authenticated-orcid":true,"given":"L. K.","family":"Dzeranova","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-6763","authenticated-orcid":true,"given":"A. V.","family":"Dorovskikh","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-466X","authenticated-orcid":true,"given":"E. A.","family":"Pigarova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-6705","authenticated-orcid":true,"given":"A. M.","family":"Lapshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-1676","authenticated-orcid":true,"given":"S. Y.","family":"Vorotnikova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-7223","authenticated-orcid":true,"given":"A. S.","family":"Shutova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-6490","authenticated-orcid":true,"given":"M. A.","family":"Perepelova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-4520","authenticated-orcid":true,"given":"A. 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Front Endocrinol (Lausanne). 2021;12(9):1158-1168. doi: https:\/\/doi.org\/10.3389\/fendo.2021.658429","DOI":"10.3389\/fendo.2021.658429"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Albani A, Berr CM, Beuschlein F, et al. A pitfall of bilateral inferior petrosal sinus sampling in cyclic Cushing\u2019s syndrome. BMC Endocr Disord. 2019;19(1):105. doi: https:\/\/doi.org\/10.1186\/s12902-019-0433-9","DOI":"10.1186\/s12902-019-0433-9"},{"key":"ref4","unstructured":"Rossiiskaia assotsiatsiia endokrinologov. Klinicheskie rekomendatsii: Bolezn\u2019 Itsenko-Kushinga. Moscow; 2021. (In Russ.)."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Albiger NME, Scaroni CM, Mantero F. Cyclic Cushing\u2019s syndrome: an overview. Arq Bras Endocrinol Metabol. 2007;51(8):1253-1260. doi: https:\/\/doi.org\/10.1590\/S0004-27302007000800011","DOI":"10.1590\/S0004-27302007000800011"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Liu Z, Zhang X, Wang Z, et al. 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