{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:16:50Z","timestamp":1737695810090,"version":"3.33.0"},"reference-count":20,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>BACKGROUND<\/jats:bold>: Childhood obesity and the rate of its spread is a serious threat to the reproductive health of the nation, especially among boys, being a background for delaying sexual development and further disrupting fertility.<jats:bold>AIM<\/jats:bold>: To study the peculiarities of the ratio of the level of leptin and a number of toxic and essential chemical trace elements in biological environments in adolescent boys aged 13\u201314 years with obesity and delayed sexual development.<jats:bold>MATERIALS AND METHODS<\/jats:bold>: Three groups of adolescents aged 13\u201314 years were studied and formed: the main ones \u2014 with constitutional exogenous obesity of 1\u20132 degrees (1\u201320 boys without secondary signs of puberty; 2 \u2014 24 boys with 2\u20134\u00a0stages of puberty according to Tanner) and comparisons (3 \u2014 15 boys with normal body weight and without deviations in puberty). The level of lead, zinc, selenium, chromium and manganese in the morning urine was determined by the absorption method; in the blood serum \u2014 leptin, by the method of enzyme immunoassay. Statistical analysis of the data was carried out in the MeoCape 11.4.2 Statistica environment, nonparametric Spearman correlation analysis and calculation of the Student\u2019s t-test for independent samples, the reliability of the results at p&lt; 0.05.<jats:bold>RESULTS<\/jats:bold>: It was found that adolescents with obesity are characterized by a certain shift in the content of toxic and essential trace elements, the vector of which is shifted towards the predominance of levels of toxic chemical elements, in particular, ead, and a decrease in essential toxic elements, such as zinc, selenium, chromium and manganese. However, a more pronounced shift in the values in the imbalance of trace elements already violates not only the metabolic processes in the body of adolescent children, but also leads to a violation of puberty - to a delay in sexual development. CONCLUSION: In the body of adolescent boys with obesity and delayed sexual development, the processes of oxidative stress, tissue hypoxia are progressing against the background of excess leptin, accumulation of heavy metals and deficiency of essential trace elements. Less pronounced shifts in the content of leptin and trace elements in adolescent boys are determined by a failure in neuroendocrine regulation, but does not affect the level of puberty. The homeostasis of the hormonal-microelement composition ensures the harmonious development of adolescent boys.<\/jats:p>","DOI":"10.14341\/probl13155","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:25:50Z","timestamp":1737627950000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["The relationship of constitutional-exogenous obesity and hormonalmicroelement status in adolescent boys with delayed sexual development"],"prefix":"10.14341","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-6354","authenticated-orcid":true,"given":"N. A.","family":"Drukker","sequence":"first","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-5198","authenticated-orcid":true,"given":"N. V.","family":"Palieva","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-8809","authenticated-orcid":true,"given":"Y. A.","family":"Petrov","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-7336","authenticated-orcid":true,"given":"V. A.","family":"\u0420opova","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref1","unstructured":"WHO.int [internet]. World Health Organization Fact sheet \u2116311. Obesity and overweight [cited 2021 Jul 6]. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/ fs311\/en"},{"key":"ref2","unstructured":"Goncharov NP, Dedov II, Gavisova AA, Suhih GT. Jendokrinnaja sistema cheloveka v razlichnye periody ego zhizni. Moscow: \u00abADAMANT\u00bb; 2020. 556 s. (in Russ.)"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"El Salam MAA. Obesity, an enemy of male fertility: a mini review. Oman Med J. 2018;33(1):3-6. doi: https:\/\/doi.org\/10.5001\/omj.2018.02","DOI":"10.5001\/omj.2018.02"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"He Y, Tian J, Oddy WH, Dwyer T, Venn AJ. Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study. Fertil Steril. 2018;110(4):596-604.e1. doi: https:\/\/doi.org\/10.1016\/j.fertnstert.2018.05.011","DOI":"10.1016\/j.fertnstert.2018.05.011"},{"key":"ref5","unstructured":"Manunova JeA, Petrov JuA, Palieva NV. Ozhirenie i reproduktivnoe zdorov\u2019e. Glavnyj vrach Juga Rossii. 2021;4(79):29-32. (in Russ.)"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tomova A, Robeva R, Kumanov P. Influence of the body weight on the onset and progression of puberty in boys. J. Pediatr. Endocrinol. Metab. 2015;28(7-8):859-865.doi: https:\/\/doi.org\/10.1515\/jpem.2014-0363","DOI":"10.1515\/jpem-2014-0363"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Lee JM, Wasserman R, Kaciroti N, et al. Timing of puberty in overweight versus obese boys. Pediatrics. 2016;137(2). doi: https:\/\/doi.org\/10.1542\/peds.2015-0164","DOI":"10.1542\/peds.2015-0164"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Cao Y, Li Z, Jiang W, et al. Reproductive functions of Kisspeptin\/KISS1R Systems in the Periphery. Reprod Biol Endocrinol. 2019;17(1):65. doi: https:\/\/doi.org\/10.1186\/s12958-019-0511-x","DOI":"10.1186\/s12958-019-0511-x"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Abreu AP, Kaiser UB. Pubertal development and regulation. Lancet Diabetes Endocrinol. 2016;4(3):254-264. doi: https:\/\/doi.org\/10.1016\/S2213-8587(15)00418-0","DOI":"10.1016\/S2213-8587(15)00418-0"},{"key":"ref10","unstructured":"Oberlis D, Harland B, Skal\u2019nyj A. Biologicheskaja rol\u2019 makro- i mikrojelementov u cheloveka i zhivotnyh. Ed by A.V. Skal\u2019nogo. Moscow: Izdatel\u2019stvo Rossijskogo universiteta druzhby narodov; 2018. 657 s. (in Russ.)"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Li L, Yang X. The essential element manganese, oxidative stress, and metabolic diseases: links and interactions. Oxid Med Cell Longev. 2018;2018:7580707. doi: https:\/\/doi.org\/10.1155\/2018\/7580707","DOI":"10.1155\/2018\/7580707"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Popova VA, Kozhin AA, Puzikova OZ, Drukker NA. Mikrojelementnyj disbalans kak faktor, potencirujushhij zaderzhku polovogo razvitija u mal\u2019chikov podrostkov s konstitucional\u2019no-jekzogennym ozhireniem. Pediatrija. 2019;1:223\u201327. (in Russ.)] doi: https:\/\/doi.org\/10.24110\/0031-403X-2019-98-1-223-227","DOI":"10.24110\/0031-403X-2019-98-1-223-227"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"B\u0142a\u017cewicz A, Klatka M, Astel A, et al. Serum and urinary selenium levels in obese children: a cross-sectional study. J Trace Elem Med Biol. 2015;29:116-122. doi: https:\/\/doi.org\/10.1016\/j.jtemb.2014.07.016","DOI":"10.1016\/j.jtemb.2014.07.016"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Cayir Y, Cayir A, Turan MI, et al. Antioxidant status in blood of obese children: the relation between trace elements, paraoxonase, and arylesterase values. Biol Trace Elem Res. 2014;160(2):155-160. doi: https:\/\/doi.org\/10.1007\/s12011-014-0038-0","DOI":"10.1007\/s12011-014-0038-0"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wan H, Wang B, Cui Yu, et al. Low-level lead exposure promotes hepatic gluconeogenesis and contributes to the elevation of fasting glucose level. Chemosphere. 2021;276:130111. doi: https:\/\/doi.org\/10.1016\/j.chemosphere.2021.130111","DOI":"10.1016\/j.chemosphere.2021.130111"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Tyrrell JB, Hafida S, Stemmer P, Adhami A, Leff T. Lead (Pb) exposure promotes diabetes in obese rodents. J Trace Elem Med Biol. 2017;39:221-226. doi: https:\/\/doi.org\/10.1016\/j.jtemb.2016.10.007","DOI":"10.1016\/j.jtemb.2016.10.007"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Wen WL, Wang CW, Wu DW, et al. Associations of heavy metals with metabolic syndrome and anthropometric indices. Nutrients. 2020;12(9):2666. doi: https:\/\/doi.org\/10.3390\/nu12092666","DOI":"10.3390\/nu12092666"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Fan Y, Zhang C, Bu J. Relationship between Selected Serum Metallic Elements and Obesity in Children and Adolescent in the U.S. Nutrients. 2017;9(2):104. doi: https:\/\/doi.org\/10.3390\/nu9020104","DOI":"10.3390\/nu9020104"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci. 2018;68(1):19-31. doi: https:\/\/doi.org\/10.1007\/s12576-017-0571-7","DOI":"10.1007\/s12576-017-0571-7"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Lapik IA, Galchenko AV, Gapparova KM. Micronutrient status in obese patients: a narrative review. Obesity Medicine. 2020;18(1):100224. doi: https:\/\/doi.org\/10.1016\/j.obmed.2020.100224","DOI":"10.1016\/j.obmed.2020.100224"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13155\/10753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13155\/10754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13155\/10794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:26:10Z","timestamp":1737627970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,6]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,1,14]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13155","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,6]]}}}