{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:57Z","timestamp":1740173517052,"version":"3.37.3"},"reference-count":20,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Cushing\u2019s disease is a rare severe neuroendocrine disorder caused by chronic overproduction of adrenocorticotropic hormone by a pituitary tumor. Supraphysiological concentrations of cortisol in endogenous hypercortisolism have an\u00a0immunosuppressive and anti-inflammatory effect similar to therapy with systemic glucocorticosteroids. This may reduce the activity of the patient\u2019s concomitant autoimmune inflammatory diseases. On the other hand, a decrease in cortisol levels during treatment for Cushing\u2019s disease may be associated with a reactivation of the immune system that pose a risk of onset or recurrence of an autoimmune disorder. We present our own clinical case demonstrating the development of sarcoidosis after surgical treatment of Cushing\u2019s disease.<\/jats:p>","DOI":"10.14341\/probl13203","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T18:16:18Z","timestamp":1706638578000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Development of sarcoidosis after successful treatment of Cushing\u2019s disease"],"prefix":"10.14341","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8483-8107","authenticated-orcid":true,"given":"P. A.","family":"Zakharova","sequence":"first","affiliation":[{"name":"Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-7366","authenticated-orcid":true,"given":"I. 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