{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:28:16Z","timestamp":1751873296899,"version":"3.37.3"},"reference-count":20,"publisher":"Endocrinology Research Centre","issue":"3","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>BACKGROUND<\/jats:bold>: The diagnostic value of calcitonin measurement in fine-needle aspiration biopsy wash-out fluid is a promising tool in the diagnosis of medullary thyroid cancer.<\/jats:p><jats:p><jats:bold>AIMS<\/jats:bold>: We assessed the potential usefulness and the diagnostic significance of Ct-FNAB alone in comparison with cytology in the diagnosis and localization of primary or metastatic MTC.<\/jats:p><jats:p><jats:bold>MATERIALS AND METHODS<\/jats:bold>: For this purpose, we retrospectively examined data from 67 patients with suspicious thyroid nodules and\/or lymph nodes who ultimately underwent surgical treatment at the Endocrinology Research Centre in 2015\u20132020. The primary endpoint of the study was to evaluate the diagnostic accuracy of Ct-FNAB when compared to cytological examination. The secondary endpoint was to determine the optimal diagnostic level for use in clinical practice.<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold>: The obtained results showed that high Ct-FNAB concentrations were present in all histologically proven MTC, either in thyroid gland (sensitivity 92.5%, specificity 100%) or neck masses (sensitivity 88.5%, specificity 100%). The optimal diagnostic threshold for Ct-FNAB values from thyroid nodes was &gt; 122 pg\/ml, from lymph nodes &gt;35.8 pg\/ml.<\/jats:p><jats:p><jats:bold>CONCLUSIONS<\/jats:bold>: Our findings suggest that Ct-FNAB is a highly reliable diagnostic procedure to identify primary and recurrent\/metastatic MTC. The actual relevance of this technique in the management of MTC needs further longitudinal studies in a larger number of patients.<\/jats:p>","DOI":"10.14341\/probl13236","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T13:21:00Z","timestamp":1688995260000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":2,"title":["Calcitonin measurement in fine-needle washout fluids in detecting medullary thyroid cancer"],"prefix":"10.14341","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-6928","authenticated-orcid":true,"given":"Z. T.","family":"Zuraeva","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-8240","authenticated-orcid":true,"given":"L. V.","family":"Nikankina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-2171","authenticated-orcid":true,"given":"G. S.","family":"Kolesnikova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-2421","authenticated-orcid":true,"given":"F. M.","family":"Abdulhabirova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-4584","authenticated-orcid":true,"given":"D. G.","family":"Beltsevich","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-9052","authenticated-orcid":true,"given":"N. M.","family":"Malysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-1767","authenticated-orcid":true,"given":"A. A.","family":"Mikheenkov","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref1","unstructured":"Bel\u2019cevich DG, Mudunov AM, Vanushko VJe, et al. Medulljarnyj rak shhitovidnoj zhelezy. Klinicheskie rekomendacii. 2020. 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