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Compensatory activation of hypothalamic-pituitary-andrenal axis results in development of a various pathological conditions caused by overstimulation of adrenal glands. Clinical spectrum may range from asymptomatic cases to severe cases of mineralocorticoid and\/or androgen excess. At present time, primary generalized glucocorticoid resistance has been exclusively associated with defects in the <jats:italic>NR3C1 <\/jats:italic>gene. Here, we present a case report of an adolescent patient with clinical presentation of glucocorticoid resistance confirmed by detailed endocrinologic evaluation but no confirmed mutations in the <jats:italic>NR3C1<\/jats:italic> gene.<\/jats:p>","DOI":"10.14341\/probl13321","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T14:30:59Z","timestamp":1709217059000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Primary Generalized Glucocorticoid Resistance: a case report"],"prefix":"10.14341","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-4200","authenticated-orcid":true,"given":"I. I.","family":"Larina","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. V.","family":"Makazan","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-7809","authenticated-orcid":true,"given":"K. V.","family":"Ivashchenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-1544","authenticated-orcid":true,"given":"N. M.","family":"Platonova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-5322","authenticated-orcid":true,"given":"E. M.","family":"Orlova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-6561","authenticated-orcid":true,"given":"M. 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