{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:40Z","timestamp":1740173500933,"version":"3.37.3"},"reference-count":15,"publisher":"Endocrinology Research Centre","issue":"4","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>According to numerous studies, the most common pituitary tumors are prolactinomas, reaching 60% of all clinically significant adenomas, the next in order are non-functional pituitary adenomas, somatotropinomas, corticotropinomas and thyrotropinomas. Plurigormonal tumors occur in less than 1% of all pituitary adenomas. The most common form of mixed secretion adenoma in this patient population, derived from the Pit-1 cell line, produces various combinations of hormones: growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (TSH). This article presents a patient with a plurihormonal two-component pituitary macroadenoma with a rare and exceptional combination of secreted hormones \u2014 GH \/ adrenocorticotropic hormone (ACTH) \/ TSH \/ follicle-stimulating hormone (FSH) \/ luteinizing hormone (LH) with minimal nonspecific clinical manifestations such as diabetes mellitus and poorly controlled arterial hypertension.<\/jats:p>","DOI":"10.14341\/probl13349","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T16:42:57Z","timestamp":1726591377000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Clinical case of plurihormonal pituitary adenoma (STH\/ACTH\/TSH\/FSH\/LH-secreting), diagnostic pitfalls"],"prefix":"10.14341","volume":"70","author":[{"given":"D. N.","family":"Kostyleva","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-5096","authenticated-orcid":true,"given":"P. M.","family":"Khandaeva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-6705","authenticated-orcid":true,"given":"A. M.","family":"Lapshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-2447","authenticated-orcid":true,"given":"E. G.","family":"Przhialkovskaya","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-6441","authenticated-orcid":true,"given":"Zh. E.","family":"Belaya","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-4520","authenticated-orcid":true,"given":"\u0410. Yu.","family":"Grigoriev","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-7877","authenticated-orcid":true,"given":"G. A.","family":"Mel\u2019nichenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"La Rosa S, Uccella S. Pituitary Tumors: Pathology and Genetics. In: Reference Module in Biomedical Sciences. Elsevier; 2018. doi: https:\/\/doi.org\/10.1016\/B978-0-12-801238-3.65086-9","DOI":"10.1016\/B978-0-12-801238-3.65086-9"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Daly AF, Beckers A. The Epidemiology of Pituitary Adenomas. Endocrinol Metab Clin North Am. 2020;49(3):347-355. doi: https:\/\/doi.org\/10.1016\/j.ecl.2020.04.002","DOI":"10.1016\/j.ecl.2020.04.002"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Irfan H, Shafiq W, Siddiqi AI, et al. Prolactinoma: Clinical Characteristics, Management and Outcome. Cureus. 2022;14(10):e29822. doi: https:\/\/doi.org\/10.7759\/cureus.29822","DOI":"10.7759\/cureus.29822"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Eremkina AK, Dzeranova LK, Pigarova EK, Mokrysheva NG, Dedov II. Morfofunktsional\u2019nye osobennosti gormonal\u2019no-neaktivnykh adenom gipofiza [Morphofunctional features of non-functioning pituitary adenomas]. 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