{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:13:55Z","timestamp":1763644435080,"version":"3.37.3"},"reference-count":80,"publisher":"Endocrinology Research Centre","issue":"5","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Leptin is not only the main regulator of energy balance, but also it affects the reproductive and immune systems. Leptin and its receptors are expressed in the endometrium and are actively involved in the embryo implantation. According to numerous studies, expression and level changes of leptin are associated with the inflammatory and autoimmune diseases, including endometriosis and chronic endometritis. Hyperplastic and inflammatory diseases of the uterus are accompanied by a violation of the receptivity of the endometrium due to the dysregulation of many factors involved in proliferation, vascularization and decidualization of cells. Activity of most of these factors is due to the leptin action, however, there are no studies of the direct effect of leptin in the pathogenesis of disorders of the endometrium in hyperplastic and inflammatory diseases.<\/jats:p><jats:p>Thus, the purpose of this literature review was to describe the putative molecular mechanisms of the effect of leptin on the development of endometrial pathology.<\/jats:p><jats:p>Literature search was carried out from 03\/20\/2023 to 05\/11\/2023 using scientific literature databases: NCBI PubMed, Google Scholar (foreign sources), Cyberleninka, Elibrary (domestic sources): references for the period 1995-2023 were analyzed. The following keywords were used for the search: leptin, endometrial dysfunction, endometrial receptivity, inflammation, pelvic inflammatory disease.<\/jats:p>","DOI":"10.14341\/probl13397","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T18:51:07Z","timestamp":1731005467000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":2,"title":["The role of leptin in endometrium disorders: literature review"],"prefix":"10.14341","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-234X","authenticated-orcid":true,"given":"K. D.","family":"Ievleva","sequence":"first","affiliation":[{"name":"Scientific Centre for Family Health and Human Reproduction"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8862-5771","authenticated-orcid":true,"given":"I. N.","family":"Danusevich","sequence":"additional","affiliation":[{"name":"Scientific Centre for Family Health and Human Reproduction"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-7803","authenticated-orcid":true,"given":"L. V.","family":"Suturina","sequence":"additional","affiliation":[{"name":"Scientific Centre for Family Health and Human Reproduction"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152:93-100. doi: https:\/\/doi.org\/10.7326\/0003-4819-152-2-201001190-00008","key":"ref1","DOI":"10.7326\/0003-4819-152-2-201001190-00008"},{"doi-asserted-by":"crossref","unstructured":"Zhang F, Chen Y, Heiman M, DiMarchi R. 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Int J Obes Relat Metab Disord. 2003;27:869-874. doi: https:\/\/doi.org\/10.1038\/sj.ijo.0802328","key":"ref8","DOI":"10.1038\/sj.ijo.0802328"},{"doi-asserted-by":"crossref","unstructured":"Shimabukuro M, Ohneda M, Lee Y, Unger RH. Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest. 1997;100(2):290-5. doi: https:\/\/doi.org\/10.1172\/JCI119534","key":"ref9","DOI":"10.1172\/JCI119534"},{"doi-asserted-by":"crossref","unstructured":"Mikhail AA, Beck EX, Shafer A, et al. Leptin stimulates fetal and adult erythroid and myeloid development. Blood.1997;89(5):1507-12","key":"ref10","DOI":"10.1182\/blood.V89.5.1507"},{"doi-asserted-by":"crossref","unstructured":"Bj\u00f8rbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. 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Mediat Inflamm. 2014;2014:1-13. doi: https:\/\/doi.org\/10.1155\/2014\/682193","key":"ref35","DOI":"10.1155\/2014\/682193"},{"doi-asserted-by":"crossref","unstructured":"Kitawaki J, Koshiba H, Ishihara H, et al. Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle. J Clin Endocrinol Metab. 2000;85(5):1946-50. doi: https:\/\/doi.org\/10.1210\/jcem.85.5.6567","key":"ref36","DOI":"10.1210\/jcem.85.5.6567"},{"doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez RR, Caballero-Campo P, Jasper M, et al. Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. J Clin Endocrinol Metab. 2000;85:4883-4888. doi: https:\/\/doi.org\/10.1210\/jcem.85.12.7060","key":"ref37","DOI":"10.1210\/jc.85.12.4883"},{"doi-asserted-by":"crossref","unstructured":"Cervero A, Horcajadas JA, Mart\u00cdn J, et al. 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Anim Reprod Sci. 2006;92:155-167. doi: https:\/\/doi.org\/10.1016\/j.anireprosci.2005.05.019","key":"ref44","DOI":"10.1016\/j.anireprosci.2005.05.019"},{"doi-asserted-by":"crossref","unstructured":"Altmae S, Reimand J, Hovatta O, et al. Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks. Mol Endocrinol. 2012;26(1):203-217. doi: https:\/\/doi.org\/10.1210\/me.2011-1196","key":"ref45","DOI":"10.1210\/me.2011-1196"},{"doi-asserted-by":"crossref","unstructured":"Fukuda J, Nasu K, Sun B, et al. Effects of leptin on the production of cytokines by cultured human endometrial stromal and epithelial cells. Fertil Steril. 2003;80(Suppl. 2):783-787. doi: https:\/\/doi.org\/10.1016\/S0015-0282(03)00776-3","key":"ref46","DOI":"10.1016\/S0015-0282(03)00776-3"},{"doi-asserted-by":"crossref","unstructured":"Conus S, Bruno A, Simon HU. Leptin is an eosinophil survival factor. J Allergy Clin Immunol. 2005;116(6):1228-1234. doi: https:\/\/doi.org\/10.1016\/J.JACI.2005.09.003","key":"ref47","DOI":"10.1016\/j.jaci.2005.09.003"},{"doi-asserted-by":"crossref","unstructured":"Zhao Y, Sun R, You L, et al. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun. 2003;300(2):247-252. doi: https:\/\/doi.org\/10.1016\/S0006-291X(02)02838-3","key":"ref48","DOI":"10.1016\/S0006-291X(02)02838-3"},{"doi-asserted-by":"crossref","unstructured":"La Cava. A Leptin in inflammation and autoimmunity. Cytokine. 2017;98:51-58. doi: https:\/\/doi.org\/10.1016\/j.cyto.2016.10.011","key":"ref49","DOI":"10.1016\/j.cyto.2016.10.011"},{"doi-asserted-by":"crossref","unstructured":"Bruun JM, Pedersen SB, Kristensen K, Richelsen B. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol. 2002;190(1-2):91-9. doi: https:\/\/doi.org\/10.1016\/s0303-7207(02)00007-2","key":"ref50","DOI":"10.1016\/S0303-7207(02)00007-2"},{"doi-asserted-by":"crossref","unstructured":"Kirchgessner TG, Uysal KT, Wiesbrock SM, et al. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1997;100:2777-2782. doi: https:\/\/doi.org\/10.1172\/JCI11982","key":"ref51","DOI":"10.1172\/JCI119824"},{"doi-asserted-by":"crossref","unstructured":"Langhans W, Hrupka B. Interleukins and tumor necrosis factor as inhibitors of food intake. Neuropeptides. 1999;33:415-424. doi: https:\/\/doi.org\/10.1054\/npep.1999.0048","key":"ref52","DOI":"10.1054\/npep.1999.0048"},{"doi-asserted-by":"crossref","unstructured":"Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. 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Diabetes. 2002;51(5):1356-61. doi: https:\/\/doi.org\/10.2337\/diabetes.51.5.1356","key":"ref56","DOI":"10.2337\/diabetes.51.5.1356"},{"doi-asserted-by":"crossref","unstructured":"Hoppin AG, M KL, Zurakowski D, et al. Serum leptin in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1998;26(5):500-505. doi: https:\/\/doi.org\/10.1097\/00005176-199805000-00003","key":"ref57","DOI":"10.1002\/j.1536-4801.1998.tb00829.x"},{"doi-asserted-by":"crossref","unstructured":"Takabatake N, Nakamura H, Abe S, et al. Circulating leptin in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;159(4I):1215-1219. doi: https:\/\/doi.org\/10.1164\/ajrccm.159.4.9806134","key":"ref58","DOI":"10.1164\/ajrccm.159.4.9806134"},{"doi-asserted-by":"crossref","unstructured":"Beach RS, Gershwin ME, Hurley LS. Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL\/1 mice \u2013 the distinction between interacting dietary influences. J Immunol. 1982;129(6):2686-2692","key":"ref59","DOI":"10.4049\/jimmunol.129.6.2686"},{"unstructured":"Masyakina AV, Kudrina EA. Diagnosis and treatment of benign hyperplastic diseases of the uterus in women with endocrine metabolic disorders. V.F. Snegirev Archives of Obstetrics and Gynecology. 2015;3:20-24. (In Rus)","key":"ref60"},{"doi-asserted-by":"crossref","unstructured":"Bedaiwy MA, Falcone T, Goldberg JM, et al. Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients. Hum Reprod. 2006;21:788-91. doi: https:\/\/doi.org\/10.1093\/humrep\/dei376","key":"ref61","DOI":"10.1093\/humrep\/dei376"},{"doi-asserted-by":"crossref","unstructured":"Wu MH, Chuang PC, Chen SM, et al. 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J Ovarian Res. 2015;8:53. doi: https:\/\/doi.org\/10.1186\/s13048-015-0180-0","key":"ref64","DOI":"10.1186\/s13048-015-0180-0"},{"doi-asserted-by":"crossref","unstructured":"Giuliani E, Parkin KL, Lessey BA, et al. Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis. Am J Reprod Immunol. 2014;72(3):262-269. doi: https:\/\/doi.org\/10.1111\/aji.12259","key":"ref65","DOI":"10.1111\/aji.12259"},{"doi-asserted-by":"crossref","unstructured":"Kim M, Park HJ, Seol JW, et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013;5(9):1415-30. doi: https:\/\/doi.org\/10.1002\/emmm.201302618","key":"ref66","DOI":"10.1002\/emmm.201302618"},{"doi-asserted-by":"crossref","unstructured":"Xiong S, Sharkey AM, Kennedy PR, et al. Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation. J Clin Invest. 2013;123(10):4264-72. doi: https:\/\/doi.org\/10.1172\/JCI68991","key":"ref67","DOI":"10.1172\/JCI68991"},{"doi-asserted-by":"crossref","unstructured":"Kieckbusch J, Gaynor LM, Moffett A, Colucci F. MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nat Commun. 2014;5:3359. doi: https:\/\/doi.org\/10.1038\/ncomms4359","key":"ref68","DOI":"10.1038\/ncomms4359"},{"doi-asserted-by":"crossref","unstructured":"Perdu S, Castellana B, Kim Y, et al. Maternal obesity drives functional alterations in uterine NK cells. JCI Insight. 2016;1(11):e85560. doi: https:\/\/doi.org\/10.1172\/jci.insight.85560","key":"ref69","DOI":"10.1172\/jci.insight.85560"},{"doi-asserted-by":"crossref","unstructured":"Olea-Flores M, Zu\u00f1iga-Eulogio M, Tacuba-Saavedra A, et al. Leptin promotes expression of EMT-related transcription factors and invasion in a src and FAK-dependent pathway in MCF10a mammary epithelial cells. Cells. 2019;8(10):1133. doi: https:\/\/doi.org\/10.3390\/cells8101133","key":"ref70","DOI":"10.3390\/cells8101133"},{"doi-asserted-by":"crossref","unstructured":"Wu MH, Chen KF, Lin SC, et al. Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1. Am J Pathol. 2007;170(2):590-598. doi: https:\/\/doi.org\/10.2353\/ajpath.2007.060477","key":"ref71","DOI":"10.2353\/ajpath.2007.060477"},{"doi-asserted-by":"crossref","unstructured":"Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-13. doi: https:\/\/doi.org\/10.1128\/MCB.16.9.4604","key":"ref72","DOI":"10.1128\/MCB.16.9.4604"},{"doi-asserted-by":"crossref","unstructured":"Nwadozi E, Ng A, Str\u00f6mberg A, et al. Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFR\u03b1 and PDGFR\u03b2 expressing perivascular cells. Angiogenesis. 2019;22(1):103-115. doi: https:\/\/doi.org\/10.1007\/s10456-018-9641-6","key":"ref73","DOI":"10.1007\/s10456-018-9641-6"},{"doi-asserted-by":"crossref","unstructured":"Cao R, Brakenhielm E, Wahlestedt C, et al. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc Natl Acad Sci USA. 2001;98(11):6390-5. doi: https:\/\/doi.org\/10.1073\/pnas.101564798","key":"ref74","DOI":"10.1073\/pnas.101564798"},{"doi-asserted-by":"crossref","unstructured":"Guo X, Yi H, Li TC, et al. Role of Vascular endothelial growth factor (VEGF) in human embryo implantation: Clinical Implications. Biomolecules. 2021;11(2):253. doi: https:\/\/doi.org\/10.3390\/biom11020253","key":"ref75","DOI":"10.3390\/biom11020253"},{"doi-asserted-by":"crossref","unstructured":"Giudice LC, Kao LC Endometriosis. Lancet. 2004;364(9447):1789-99. doi: https:\/\/doi.org\/10.1016\/S0140-6736(04)17403-5","key":"ref76","DOI":"10.1016\/S0140-6736(04)17403-5"},{"unstructured":"Halme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64:151-154","key":"ref77"},{"doi-asserted-by":"crossref","unstructured":"Danusevich IN, Lazareva LM, Nemchenko UM, Kolesnikova LI. Endometrial Cytokines in Women with Reproductive Disorders. International Journal of Biomedicine. 2021;11(4):526-531. doi: https:\/\/doi.org\/10.21103\/Article11(4)_OA20","key":"ref78","DOI":"10.21103\/Article11(4)_OA20"},{"doi-asserted-by":"crossref","unstructured":"Danusevich IN, Sharifulin EM, Nemchenko UM, Kolesnikova LI. Features of the immune system functioning with persistence of infectious agents in women with chronic endometrial inflammation and reproductive disorders. International Journal of Biomedicine. 2020;10(4):362-368. doi: https:\/\/doi.org\/10.21103\/Article10(4)_OA6","key":"ref79","DOI":"10.21103\/Article10(4)_OA6"},{"doi-asserted-by":"crossref","unstructured":"Hashimoto Y, Tsuzuki-Nakao T, Kida N, et al. Inflammatory cytokine-induced HIF-1 activation promotes epithelial-mesenchymal transition in endometrial epithelial cells. 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