{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:11:42Z","timestamp":1784664702806,"version":"3.55.0"},"reference-count":20,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p><jats:bold>BACKGROUND<\/jats:bold>. KI-67 (MKI-67 in humans) is a protein able to bind to DNA which contributes to cell growth and cell proliferation. KI-67 is currently considered as a biomarker that is widely utilized as prognostic indicator for evaluating cell proliferation, diagnosing diseases, and conducting research. Several different kinds of cancer have high Ki-67 expression, which simplifying the choice of treatment for individuals with various cancer types.<jats:bold>AIM<\/jats:bold>. The objective was to evaluate the expression of KI67 in patients suffering papillary thyroid cancer (PTC) also the association between patients age and gender and KI67 expression.<jats:bold>MATERIALS AND METHODS<\/jats:bold>. To undertake an in-depth investigation of KI67 in malignant and normal tissues, we used thyroid tissue sections to analyze KI67 expression in 70 samples, 50 different PTC (44 female and 6 male), and 20 normal types (10 for each gender). Each group\u2019s average age is between 20 and 60.<jats:bold>RESULTS<\/jats:bold>. The analysis of the data revealed a substantial difference in the expression of ki67 between the patients and control groups. Ki67 expression and either gender or age did not significantly correlate.<jats:bold>CONCLUSION<\/jats:bold>. This study suggest that KI67 may be a crucial marker for assessing the aggressiveness of tumors and inflammatory diseases.<\/jats:p>","DOI":"10.14341\/probl13410","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:25:50Z","timestamp":1737627950000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["KI-67 as a predictive indicator of papillary thyroid cancer in Iraqi patients"],"prefix":"10.14341","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8959-8505","authenticated-orcid":true,"given":"Noor Mohammed","family":"Al-Timimi","sequence":"first","affiliation":[{"name":"Uniuniversity of Baghdad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abed Hassan","family":"Baraaj","sequence":"additional","affiliation":[{"name":"Uniuniversity of Baghdad"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5458","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Khachatryan MA, Mkhitaryan LM. Papillary thyroid cancer, Hashimoto\u2019s thyroiditis, adenomatoid hyperplasia. Do they have any connection? Problems of Endocrinology. 2016;62(5):55-56. doi: https:\/\/doi.org\/10.14341\/probl201662555-56","DOI":"10.14341\/probl201662555-56"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Doubi A, Al-Qannass A, Al-Angari SS, Al-Qahtani KH, Alessa M, Al-Dhahri S. Trends in thyroid carcinoma among thyroidectomy patients: A 12-year multicenter study. Ann Saudi Med. 2019. doi: https:\/\/doi.org\/10.5144\/0256-4947.2019.345","DOI":"10.5144\/0256-4947.2019.345"},{"key":"ref3","unstructured":"Lloyd RV, Osamura RY, Kloppel G, et al. WHO classification of tumours of endocrine organs. Lyon: (IARC). 2017. Available from: https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Who-Classification-Of-Tumours\/WHO-Classification-Of-Tumours-Of-Endocrine-Organs-2017"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G. Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2020;11. doi: https:\/\/doi.org\/10.3389\/fendo.2020.00265","DOI":"10.3389\/fendo.2020.00265"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Dwivedi SS. Study of Immunohistochemical Markers (CK-19, CD-56, Ki-67, p53) in Differentiating Benign and Malignant Solitary Thyroid Nodules with special Reference to Papillary Thyroid Carcinomas. J Clin DIAGNOSTIC Res. 2016. doi: https:\/\/doi.org\/10.7860\/JCDR\/2016\/22428.9114","DOI":"10.7860\/JCDR\/2016\/22428.9114"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"LI LT, JIANG G, CHEN Q, ZHENG JN. Ki67 is a promising molecular target in the diagnosis of cancer (Review). Mol Med Rep. 2015;11(3):1566-1572. doi: https:\/\/doi.org\/10.3892\/mmr.2014.2914","DOI":"10.3892\/mmr.2014.2914"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Lindfors H, Karlsen M, Karlton E, et al. Thyroglobulin expression, Ki-67 index, and lymph node ratio in the prognostic assessment of papillary thyroid cancer. Sci Rep. 2023;13(1):1070. doi: https:\/\/doi.org\/10.1038\/s41598-023-27684-3","DOI":"10.1038\/s41598-023-27684-3"},{"key":"ref8","unstructured":"Somuncu E. What is the meaning of ki67 expression in papillary thyroid cancer? Biomed. Res. 2021:S49-S52. Available from: https:\/\/www.alliedacademies.org\/articles\/what-is-the-meaning-of-ki67-expression-in-papillary-thyroid-cancer.pdf"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Ahmed S, Rashed H, Hegazy A, Mohamed AM, Elmesallamy W. Prognostic value of aldh1, ezh2 and ki-67 in astrocytic gliomas. Turkish J Pathol. 2016. doi: https:\/\/doi.org\/10.5146\/tjpath.2015.01344","DOI":"10.5146\/tjpath.2015.01344"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Davey MG, Hynes SO, Kerin MJ, Miller N, Lowery AJ. Ki-67 as a Prognostic Biomarker in Invasive Breast Cancer. Cancers (Basel). 2021;13(17):4455. doi: https:\/\/doi.org\/10.3390\/cancers13174455","DOI":"10.3390\/cancers13174455"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"MAIA R, SANTOS GA DOS, REIS S, et al. Can we use Ki67 expression to predict prostate cancer aggressiveness? Rev Col Bras Cir. 2022;49. doi: https:\/\/doi.org\/10.1590\/0100-6991e-20223200-en","DOI":"10.1590\/0100-6991e-20223200"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Suhaimi SNA, Shuhaili MA, Isa NM, Puad SHM, Shah SA, Mohammad R. The Missing Link between Ki-67 and Papillary Thyroid Carcinoma. World J Endocr Surg. 2020;12(2):80-85. doi: https:\/\/doi.org\/10.5005\/jp-journals-10002-1287","DOI":"10.5005\/jp-journals-10002-1287"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Sun X, Kaufman PD. Ki-67: more than a proliferation marke. Chromosoma. 2018;127(2):175\u2013186. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5945335\/","DOI":"10.1007\/s00412-018-0659-8"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Remnant L, Kochanova NY, Reid C, Cisneros-Soberanis F, Earnshaw WC. The intrinsically disorderly story of Ki-67. Open Biol. 2021. doi: https:\/\/doi.org\/10.1098\/rsob.210120","DOI":"10.1098\/rsob.210120"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Zhou Y, Jiang H-G, Lu N, Lu B-H, Chen Z-H. Expression of Ki67 in Papillary Thyroid Microcarcinoma and its Clinical Significance. Asian Pacific J Cancer Prev. 2015;16(4):1605-1608. doi: https:\/\/doi.org\/10.7314\/APJCP.2015.16.4.1605","DOI":"10.7314\/APJCP.2015.16.4.1605"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Tran QL, Davies L. Thyroid cancer incidence differences between men and women. Curr Opin Endocr Metab Res. 2023. doi: https:\/\/doi.org\/10.1016\/j.coemr.2023.100472","DOI":"10.1016\/j.coemr.2023.100472"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Yu L, Hong H, Han J, Leng SX, Zhang H, Yan X. Comparison of Survival and Risk Factors of Differentiated Thyroid Cancer in the Geriatric Population. Front Oncol. 2020;10. doi: https:\/\/doi.org\/10.3389\/fonc.2020.00042","DOI":"10.3389\/fonc.2020.00042"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Lei Y, Zhao X, Feng Y, He D, Hu D, Min Y. The Value of Ki-67 Labeling Index in Central Lymph Node Metastasis and Survival of Papillary Thyroid Carcinoma: Evidence From the Clinical and Molecular Analyses. Cancer Control. 2023;30. doi: https:\/\/doi.org\/10.1177\/10732748231155701","DOI":"10.1177\/10732748231155701"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Siironen P, Nordling S, Louhimo J, Haapiainen R, Haglund C. Immunohistochemical expression of Bcl-2, Ki-67, and p21 in patients with papillary thyroid cancer: Increased Ki-67 expression in older patients. Tumor Biol. 2005. doi: https:\/\/doi.org\/10.1159\/000084340","DOI":"10.1159\/000084340"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Pan DH, Wen DY, Luo YH, et al. The diagnostic and prognostic values of KI-67\/ MIB-1 expression in thyroid cancer: A meta-analysis with 6,051 cases. Onco Targets Ther. 2017. doi: https:\/\/doi.org\/10.2147\/OTT.S135593","DOI":"10.2147\/OTT.S135593"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13410\/10789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13410\/10757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13410\/10759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:26:22Z","timestamp":1737627982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,1,14]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13410","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}