{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:35:10Z","timestamp":1791477310218,"version":"4.3.4"},"reference-count":58,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Disorders of calcium and phosphorus metabolism can cause severe complications that require changing of therapeutic strategies and a long treatment in a hospital. The prevalence of diseases accompanied by calcium metabolism disorders varies from low to moderate. For example, primary hyperparathyroidism, as one of the most common causes of pathological changes in calcium metabolism due to parathyroid hormone hypersecretion, occurs with a frequency of 85 to 233 cases per 100 thousand people. In countries where blood calcium measurements are not routinely carried out, this disease and similar conditions are diagnosed less frequently, and at later stages, with a predominance of manifest and complicated forms. However, calcium metabolism disorders require timely detection and correction in order to prevent complications. At the\u00a0same time, in a number of clinical situations, standard laboratory analysis is not the optimal diagnostic option due to the duration and complexity of its implementation. In particular, the development of acute hyper- and hypocalcemia requires faster obtaining of blood test results. It is promising to apply technologies allowing to quick assess the current level of calcium directly at a doctor\u2019s appointment especially in cases of drug doses adjustment for patients with chronic disorders of calcium metabolism. In this regard, when long-term monitoring of calcemia is required or in emergency situations, the potential benefit can be obtained by using portable Point-of-Care (POC) devices or wearable biosensors. This review examines the clinical and methodological aspects of monitoring calcium levels, their capabilities and practical limitations, and also highlights the\u00a0prospects for the development and implementation of POC devices and biosensors for ionized calcium.<\/jats:p>","DOI":"10.14341\/probl13413","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:25:50Z","timestamp":1737627950000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Significance and methodology of monitoring calcemia in disorders of mineral metabolism: challenges and prospects"],"prefix":"10.14341","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9010-4142","authenticated-orcid":true,"given":"K. 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Front Cell Dev Biol. 2020;8:576110. doi: https:\/\/doi.org\/10.3389\/fcell.2020.576110","DOI":"10.3389\/fcell.2020.576110"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Tonon CR, Silva TAAL, Pereira FWL, et al. A Review of Current Clinical Concepts in the Pathophysiology, Etiology, Diagnosis, and Management of Hypercalcemia. Med Sci Monit Int Med J Exp Clin Res. 2022;28:e935821. doi: https:\/\/doi.org\/10.12659\/MSM.935821","DOI":"10.12659\/MSM.935821"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Bove-Fenderson E, Mannstadt M. Hypocalcemic disorders. Best Pract Res Clin Endocrinol Metab. 2018;32(5):639-656. doi: https:\/\/doi.org\/10.1016\/j.beem.2018.05.006","DOI":"10.1016\/j.beem.2018.05.006"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Mirzazadeh M, Morovat A, James T, et al. Point-of-care testing of electrolytes and calcium using blood gas analysers: it is time we trusted the results. Emerg Med J EMJ. 2016;33(3):181-186. doi: https:\/\/doi.org\/10.1136\/emermed-2015-204669","DOI":"10.1136\/emermed-2015-204669"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Guilmette J, Sadow PM. Parathyroid Pathology. Surg Pathol Clin. 2019;12(4):1007-1019. doi: https:\/\/doi.org\/10.1016\/j.path.2019.08.006","DOI":"10.1016\/j.path.2019.08.006"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Yeh MW, Ituarte PHG, Zhou HC, et al. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab. 2013;98(3):1122-1129. doi: https:\/\/doi.org\/10.1210\/jc.2012-4022","DOI":"10.1210\/jc.2012-4022"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Mokrysheva NG, Eremkina AK, Elfimova AR, et al. The Russian registry of primary hyperparathyroidism, latest update. Front Endocrinol. 2023;14:1203437. doi: https:\/\/doi.org\/10.3389\/fendo.2023.1203437","DOI":"10.1530\/endoabs.90.EP133"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Bilezikian JP, Bandeira L, Khan A, et al. Hyperparathyroidism. Lancet Lond Engl. 2018;391(10116):168-178. doi: https:\/\/doi.org\/10.1016\/S0140-6736(17)31430-7","DOI":"10.1016\/S0140-6736(17)31430-7"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Mokrysheva NG, Eremkina AK, Mirnaya SS, et al. The clinical practice guidelines for primary hyperparathyroidism, short version. Problems of Endocrinology. 2021;67(4):94-124. (In Russ.)] doi: https:\/\/doi.org\/10.14341\/probl12801-9964","DOI":"10.14341\/probl12801"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Dobreva EA, Mirnaya SS, Volodicheva VL, et al. Analysis of calcemic in residents of the cities of Khimki and Kolomna, Moscow region. Profil Meditsina. 2020;23(5):99. (In Russ.)]. doi: https:\/\/doi.org\/10.17116\/profmed20202305199","DOI":"10.17116\/profmed20202305199"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Clarke BL, Brown EM, Collins MT, et al. Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016;101(6):2284-2299. doi: https:\/\/doi.org\/10.1210\/jc.2015-3908","DOI":"10.1210\/jc.2015-3908"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Krupinova JA, et al. Review of clinical practice guidelines for hypoparathyroidism. Problems of Endocrinology. 2021;67(4):68-83. (In Russ.)] doi: https:\/\/doi.org\/10.14341\/probl12800-9962","DOI":"10.14341\/probl12800"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Mokrysheva NG. Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series. Obesity and metabolism. 2021;18(2):175-179. (In Russ.)] doi: https:\/\/doi.org\/10.14341\/omet12729-9865","DOI":"10.14341\/omet12729"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Chandran M, Wong J. Secondary and Tertiary Hyperparathyroidism in Chronic Kidney Disease: An Endocrine and Renal Perspective. Indian J Endocrinol Metab. 2019;23(4):391. doi: https:\/\/doi.org\/10.4103\/ijem.IJEM_292_19","DOI":"10.4103\/ijem.IJEM_292_19"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2017;7(1):1-59. doi: https:\/\/doi.org\/10.1016\/j.kisu.2017.04.001","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Makazan NV, Orlova EM, Tozliyan EV, et al. Variable phenotype of pseudohypoparathyroidism in children. Problems of Endocrinology. 2017;63(3):148-161. (In Russ.)] doi: https:\/\/doi.org\/10.14341\/probl8337-6447","DOI":"10.14341\/probl2017633148-161"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Shchederkina IO, Orlova KA, Koltunov IE, et al. Difficulties in the differential diagnosis of epileptic and hypocalcemic seizures in children and adolescents. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1S):66-74. (In Russ.)] doi: https:\/\/doi.org\/10.14412\/2074-2711-2018-1S-66-74","DOI":"10.14412\/2074-2711-2018-1S-66-74"},{"key":"ref21","unstructured":"Shao Y, Cai WJ, Wang XL, et al. Clinical data analysis of 22 cases with hypoparathyroidism misdiagnosed as epilepsy. Neuro Endocrinol Lett. 2022;43(2):113-118"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Nardone R, Brigo F, Trinka E. Acute Symptomatic Seizures Caused by Electrolyte Disturbances. J Clin Neurol Seoul Korea. 2016;12(1):21-33. doi: https:\/\/doi.org\/10.3988\/jcn.2016.12.1.21","DOI":"10.3988\/jcn.2016.12.1.21"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Li L, Yang H, Li J, et al. Misdiagnosis of idiopathic hypoparathyroidism: A case report and literature review. Medicine (Baltimore). 2018;97(9):e9884. doi: https:\/\/doi.org\/10.1097\/MD.0000000000009884","DOI":"10.1097\/MD.0000000000009884"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"El-Hajj Fuleihan G, Clines GA, Hu MI, et al. Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2023;108(3):507-528. doi: https:\/\/doi.org\/10.1210\/clinem\/dgac621","DOI":"10.1210\/clinem\/dgac621"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Gastanaga VM, Schwartzberg LS, Jain RK, et al. Prevalence of hypercalcemia among cancer patients in the United States. Cancer Med. 2016;5(8):2091-2100. doi: https:\/\/doi.org\/10.1002\/cam4.749","DOI":"10.1002\/cam4.749"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Asonitis N, Angelousi A, Zafeiris C, et al. Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature. Horm Metab Res Horm Stoffwechselforschung Horm Metab. 2019;51(12):770-778. doi: https:\/\/doi.org\/10.1055\/a-1049-0647","DOI":"10.1055\/a-1049-0647"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Bhandari S, Kumar R, Tripathi P, et al. Outcomes of hypercalcemia of malignancy in patients with solid cancer: a national inpatient analysis. Med Oncol Northwood Lond Engl. 2019;36(10):90. doi: https:\/\/doi.org\/10.1007\/s12032-019-1315-8","DOI":"10.1007\/s12032-019-1315-8"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Ciosek \u017b, Kot K, Kosik-Bogacka D, et al. The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue. Biomolecules. 2021;11(4):506. doi: https:\/\/doi.org\/10.3390\/biom11040506","DOI":"10.3390\/biom11040506"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Belaya ZE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4-47. (In Russ.)] doi: https:\/\/doi.org\/10.14341\/osteo12930","DOI":"10.14341\/osteo12930"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician\u2019s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022;33(10):2049-2102. doi: https:\/\/doi.org\/10.1007\/s00198-021-05900-y","DOI":"10.1007\/s00198-021-05900-y"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pekar JD, Grzych G, Durand G, et al. Calcium state estimation by total calcium: the evidence to end the neverending story. Clin Chem Lab Med. 2020;58(2):222-231. doi: https:\/\/doi.org\/10.1515\/cclm-2019-0568","DOI":"10.1515\/cclm-2019-0568"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Conrich-Wilks G, Ivison F, Kilpatrick ES. Factors influencing the derivation and clinical application of blood calcium adjustment equations. Ann Clin Biochem. 2023;60(1):54-62. doi: https:\/\/doi.org\/10.1177\/00045632221131673","DOI":"10.1177\/00045632221131673"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Ridefelt P, Helmersson-Karlqvist J. Albumin adjustment of total calcium does not improve the estimation of calcium status. Scand J Clin Lab Invest. 2017;77(6):442-447. doi: https:\/\/doi.org\/10.1080\/00365513.2017.1336568","DOI":"10.1080\/00365513.2017.1336568"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Bilezikian JP, Cusano NE, Khan AA, et al. Primary hyperparathyroidism. Nat Rev Dis Primer. 2016;2:16033. doi: https:\/\/doi.org\/10.1038\/nrdp.2016.33","DOI":"10.1038\/nrdp.2016.33"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Jassam N, O\u2019Kane M. Harmonisation of adjusted calcium equation, is it a realistic aim: a narrative review. J Lab Precis Med. 2023;8(0). doi: https:\/\/doi.org\/10.21037\/jlpm-22-56","DOI":"10.21037\/jlpm-22-56"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Jassam N, Thomas A, Hayden K, et al. The impact of the analytical performance specifications of calcium and albumin on adjusted calcium. Ann Clin Biochem. 2020;57(5):382-388. doi: https:\/\/doi.org\/10.1177\/0004563220944426","DOI":"10.1177\/0004563220944426"},{"key":"ref37","unstructured":"Rifai N. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2022"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Schini M, Hannan FM, Walsh JS, et al. Reference interval for albuminadjusted calcium based on a large UK population. Clin Endocrinol (Oxf ). 2021;94(1):34-39. doi: https:\/\/doi.org\/10.1111\/cen.14326","DOI":"10.1111\/cen.14326"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Li M, Wang C, Zhou EW, et al. Time to stop debating about the everlasting story: Some issues concerning serum total calcium and ionized calcium. Chin Med J (Engl). 2020;133(10):1251-1252. doi: https:\/\/doi.org\/10.1097\/CM9.0000000000000803","DOI":"10.1097\/CM9.0000000000000803"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Minisola S, Pepe J, Cipriani C. Measuring serum calcium: Total, albumin-adjusted or ionized? Clin Endocrinol (Oxf ). 2021;95(2):267-268. doi: https:\/\/doi.org\/10.1111\/cen.14362","DOI":"10.1111\/cen.14362"},{"key":"ref41","unstructured":"Hyperparathyroidism (Primary): Diagnosis, Assessment and Initial Management. London: National Institute for Health and Care Excellence (NICE); 2019. Accessed December 17, 2023. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542087\/"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Tartaglia F. Is ionized calcium a reliable predictor of hypocalcemia after total thyroidectomy? A before and after study. G di Chir - J Surg. 2014. doi: https:\/\/doi.org\/10.11138\/gchir\/2014.35.1.027","DOI":"10.11138\/gchir\/2014.35.1.027"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Tee MC, Holmes DT, Wiseman SM. Ionized vs serum calcium in the diagnosis and management of primary hyperparathyroidism: which is superior? Am J Surg. 2013;205(5):591-596. doi: https:\/\/doi.org\/10.1016\/j.amjsurg.2013.01.017","DOI":"10.1016\/j.amjsurg.2013.01.017"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Nieto B, Gismera MJ, Sevilla MT, et al. Micro-sampling method based on high-resolution continuum source graphite furnace atomic absorption spectrometry for calcium determination in blood and mitochondrial suspensions. Talanta. 2017;170:15-21. doi: https:\/\/doi.org\/10.1016\/j.talanta.2017.03.086","DOI":"10.1016\/j.talanta.2017.03.086"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Zhao HJ, Ge ML, Yan Y, et al. Inductively Coupled Plasma Mass Spectrometry as a Reference Method to Evaluate Serum Calcium Measurement Bias and the Commutability of Processed Materials during Routine Measurements. Chin Med J (Engl). 2018;131(13):1584-1590. doi: https:\/\/doi.org\/10.4103\/0366-6999.235109","DOI":"10.4103\/0366-6999.235109"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Yan Y, Ge M, Ma R, et al. A candidate reference method for serum calcium measurement by inductively coupled plasma mass spectrometry. Clin Chim Acta Int J Clin Chem. 2016;461:141-145. doi: https:\/\/doi.org\/10.1016\/j.cca.2016.07.004","DOI":"10.1016\/j.cca.2016.07.004"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Lyu Y, Gan S, Bao Y, et al. Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors. Membranes. 2020;10(6):128. doi: https:\/\/doi.org\/10.3390\/membranes10060128","DOI":"10.3390\/membranes10060128"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Wang P, Kricka LJ. Current and Emerging Trends in Pointof-Care Technology and Strategies for Clinical Validation and Implementation. Clin Chem. 2018;64(10):1439-1452. doi: https:\/\/doi.org\/10.1373\/clinchem.2018.287052","DOI":"10.1373\/clinchem.2018.287052"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Vashist SK. Point-of-Care Diagnostics: Recent Advances and Trends. Biosensors. 2017;7(4):62. doi: https:\/\/doi.org\/10.3390\/bios7040062","DOI":"10.3390\/bios7040062"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Jawa A, Motara F, Moolla M, Laher AE. A Comparative Assessment of the Nova Stat Profile Prime Plus\u00ae Critical Care Analyzer. Cureus. 2020;12(8):e9932. doi: https:\/\/doi.org\/10.7759\/cureus.9932","DOI":"10.7759\/cureus.9932"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Leal Yepes FA, Behling-Kelly E, Caixeta LS, et al. Evaluation of a pointof-care calcium device in bovine plasma and serum. JDS Commun. 2023;4(5):390-393. doi: https:\/\/doi.org\/10.3168\/jdsc.2022-0346","DOI":"10.3168\/jdsc.2022-0346"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Couto Serrenho R, Bruinj\u00e9 TC, Morrison EI, et al. Validation of a point-of-care handheld blood total calcium analyzer in postpartum dairy cows. JDS Commun. 2021;2(1):41-45. doi: https:\/\/doi.org\/10.3168\/jdsc.2020-0006","DOI":"10.3168\/jdsc.2020-0006"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Suzuki K, Kondo N, Takagi K, et al. Validation of the bovine blood calcium checker as a rapid and simple measuring tool for the ionized calcium concentration in cattle. J Vet Med Sci. 2021;83(5):767-774. doi: https:\/\/doi.org\/10.1292\/jvms.21-0001","DOI":"10.1292\/jvms.21-0001"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Keresten V, Mikhelson K. Voltammetric Ion Sensing with IonophoreBased Ion-Selective Electrodes Containing Internal Aqueous Solution, Improving Lifetime of Sensors. Membranes (Basel). 2022;12(11):1048. doi: https:\/\/doi.org\/10.3390\/membranes12111048","DOI":"10.3390\/membranes12111048"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Nyein HYY, Gao W, Shahpar Z, et al. A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca(2+) and pH. ACS Nano. 2016;10(7):7216-7224. doi: https:\/\/doi.org\/10.1021\/acsnano.6b04005","DOI":"10.1021\/acsnano.6b04005"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Molinero-Fern\u00e1ndez \u00c1, Casanova A, Wang Q, et al. In Vivo Transdermal Multi-Ion Monitoring with a Potentiometric Microneedle-Based Sensor Patch. ACS Sens. 2023;8(1):158-166. doi: https:\/\/doi.org\/10.1021\/acssensors.2c01907","DOI":"10.1021\/acssensors.2c01907"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Lechner M, Moghul G, Chandrasekharan D, et al. Preoperative and postoperative optimisation of patients undergoing thyroid surgery: a multicentre quality improvement project at Barts Health NHS Trust. BMJ Open Qual. 2023;12(2):e001190. doi: https:\/\/doi.org\/10.1136\/bmjoq-2020-001190","DOI":"10.1136\/bmjoq-2020-001190"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Schwarzer P, Kuhn SO, Stracke S, et al. Discrepant post filter ionized calcium concentrations by common blood gas analyzers in CRRT using regional citrate anticoagulation. 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