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Terapevticheskij arhiv. 2018;90(10):14-22 (In Russ.).] doi: https:\/\/doi.org\/10.26442\/terarkh201890104-22","DOI":"10.26442\/terarkh201890104-22"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Balanova YuA, Shalnova SA, Deev AD, et al. Obesity in russian population \u2014 prevalence and association with the non-communicable diseases risk factors. Russian Journal of Cardiology. 2018;(6):123-130. (In Russ.).] doi: https:\/\/doi.org\/10.15829\/1560-4071-2018-6-123-130","DOI":"10.15829\/1560-4071-2018-6-123-130"},{"key":"ref17","unstructured":"WHO \u2013 Obesity and overweight. Available from: https:\/\/who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Alferova VI, Mustafina SV. The prevalence of obesity in the adult population of the Russian Federation (literature review). Obesity and metabolism. 2022;19(1):96-105. 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Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab. 2006; 290: E916-\u0415924. doi: https:\/\/doi.org\/10.1152\/ajpendo.00410.2005","DOI":"10.1152\/ajpendo.00410.2005"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Narvaez CJ, Simmons KM, Brunton J, et al. Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. J Cell Physiol. 2013;228:2024-2036. doi: https:\/\/doi.org\/10.1002\/jcp.24371","DOI":"10.1002\/jcp.24371"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. 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Infekc. bolezni (Infectious Diseases). 2023;21(1):162\u2013170. (In Russian).] doi: https:\/\/doi.org\/10.20953\/1729-9225-2023-1-162-170","DOI":"10.20953\/1729-9225-2023-1-162-170"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770. doi: https:\/\/doi.org\/10.1126\/science.1123933","DOI":"10.1126\/science.1123933"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Agier J, Efenberger M, Brzezi\u0144ska-B\u0142aszczyk E. Cathelicidin impact on inflammatory cells. Cent Eur J Immunol. 2015;40(2):225-235. doi: https:\/\/doi.org\/10.5114\/ceji.2015.51359","DOI":"10.5114\/ceji.2015.51359"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Barlow PG, Svoboda P, Mackellar A, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One. 2011;6(10):e25333. doi: https:\/\/doi.org\/10.1371\/journal.pone.0025333","DOI":"10.1371\/journal.pone.0025333"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Cantorna MT, Snyder L, Lin YD, Yang L. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 2015;7(4):3011-3021. doi: https:\/\/doi.org\/10.3390\/nu7043011","DOI":"10.3390\/nu7043011"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Suplotova LA, Avdeeva VA, Pigarova EA, et al. The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation. Terapevticheskii arkhiv. 2021;93(10):1209-1216 (In Russian).] doi: https:\/\/doi.org\/10.26442\/00403660.2021.10.201071","DOI":"10.26442\/00403660.2021.10.201071"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE. Acute respiratory tract infection and 25-hydroxyvitamin D concentration: a systematic review and meta-analysis. Int J Environ Res Public Health. 2019;16(17):3020. doi: https:\/\/doi.org\/10.3390\/ijerph16173020","DOI":"10.3390\/ijerph16173020"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Berry D, Hesketh K, Power C, Hypp\u00f6nen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. British J Nutrition. 2011;106(9):1433-1440. doi: https:\/\/doi.org\/10.1017\/S0007114511001991","DOI":"10.1017\/S0007114511001991"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Karonova TL, Kudryavtsev IV, Golovatyuk KA, et al. Vitamin D status and immune response in hospitalized patients with moderate and severe COVID-19. Pharmaceuticals (Basel). 2022;15(3):305. doi: https:\/\/doi.org\/10.3390\/ph15030305","DOI":"10.3390\/ph15030305"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Karonova TL, Golovatyuk KA, Kudryavtsev IV, et al. Effect of cholecalciferol supplementation on the clinical features and inflammatory markers in hospitalized COVID-19 patients: a randomized, open-label, single-center study. Nutrients. 2022;14(13):2602. doi: https:\/\/doi.org\/10.3390\/nu14132602","DOI":"10.3390\/nu14132602"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Karonova TL, Mikhaylova AA, Golovatyuk KA, et al. Vitamin D metabolism parameters and cytokine profile in COVID-19 patients with bolus cholecalciferol supplementation. Diagnostics (Basel). 2024;14(13):1408. doi: https:\/\/doi.org\/10.3390\/diagnostics14131408","DOI":"10.3390\/diagnostics14131408"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Dedov II, Mel\u2019nichenko GA, Mokrysheva NG, et al. Draft federal clinical practice guidelines for the diagnosis, treatment, and prevention of vitamin D deficiency. Osteoporosis and Bone Diseases. 2021;24(4):4-26. (In Russ.).] doi: https:\/\/doi.org\/10.14341\/osteo12937","DOI":"10.14341\/osteo12937"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Afzal S, Bojesen SE, Nordestgaard BG. Low 25-Hydroxyvitamin D and Risk of Type 2 Diabetes: A Prospective Cohort Study and Metaanalysis. Clin Chem. 2013;59:381-391. doi: https:\/\/doi.org\/10.1373\/clinchem.2012.193003","DOI":"10.1373\/clinchem.2012.193003"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Lotfi-Dizaji L, Mahboob S, Aliashrafi S, et al. Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: A doubleblind placebo-controlled randomized clinical trial. Clin Endocrinol. 2019;90:94-101. doi: https:\/\/doi.org\/10.1111\/cen.13861","DOI":"10.1111\/cen.13861"},{"key":"ref63","unstructured":"\u0414\u0430\u043d\u043d\u044b\u0435 \u0441\u0430\u0439\u0442\u0430 \u0413\u0420\u041b\u0421. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e: https:\/\/grls.rosminzdrav.ru\/Default.aspx"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Helde Frankling M, Norlin AC, Hansen S, et al. Are vitamin D3 tablets and oil drops equally effective in raising S-25-hydroxyvitamin D concentrations? A post-hoc analysis of an observational study on immunodeficient patients. 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