{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:06:37Z","timestamp":1779307597010,"version":"3.51.4"},"reference-count":25,"publisher":"Endocrinology Research Centre","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND<\/jats:bold>\n                    . Obesity and type 2 diabetes (T2D) are common metabolic disorders. Oxytocin, a hypothalamic neuropeptide, has recently been recognized as a potential regulator of energy balance, appetite, and insulin sensitivity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE<\/jats:bold>\n                    . To investigate the relationship between circulating oxytocin levels and metabolic parameters in individuals with obesity and newly diagnosed T2D.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MATERIALS AND METHODS<\/jats:bold>\n                    . A total of 96 participants were enrolled, including 48 with normal glucose tolerance (NGT) and 48 with newly diagnosed T2D, each subdivided into normal-weight and obese groups. Anthropometric indices, glucose and lipid parameters, insulin, HbA\n                    <jats:sub>1c<\/jats:sub>\n                    , and high-sensitivity C-reactive protein were measured. Insulin resistance and \u03b2-cell function were assessed using the HOMA model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS<\/jats:bold>\n                    . Circulating oxytocin levels were significantly lower in patients with T2D compared to NGT (p &lt; 0.01), and in obese compared to normal-weight participants (p &lt; 0.01). Low oxytocin was negatively correlated with BMI, waist circumference, HbA1c, glucose, insulin, lipids, and hs-CRP, but positively with \u03b2-cell function. Multiple regression analysis identified 2-hour glucose, BMI, and total cholesterol as independent predictors of oxytocin levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION<\/jats:bold>\n                    . Patients with obesity and newly diagnosed T2D exhibit markedly reduced circulating oxytocin levels, associated with adverse metabolic profiles. These findings highlight oxytocin as a potential biomarker of early metabolic dysregulation and suggest new therapeutic perspectives.\n                  <\/jats:p>","DOI":"10.14341\/probl13587","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:22:08Z","timestamp":1779304928000},"page":"61-68","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Decreased blood oxytocin levels in obesity and in patients with newly diagnosed type 2 diabetes"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6866-6760","authenticated-orcid":true,"given":"S. Sh.","family":"Anvarova","sequence":"first","affiliation":[{"name":"Republican Specialized Scientific and Practical Center of Endocrinology named after Acad. Y.H. Turakulov"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-3633","authenticated-orcid":true,"given":"G. D.","family":"Narimova","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Center of Endocrinology named after Acad. Y.H. Turakulov"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bartz JA, Zaki J, Ochsner KN, et al. Effects of oxytocin on recollections of maternal care and closeness. Proc Natl Acad Sci U S A. 2010;107(50):21371-5. doi:10.1073\/pnas.1012669107","DOI":"10.1073\/pnas.1012669107"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Cai D, Purkayastha S. A new horizon: oxytocin as a novel therapeutic option for obesity and diabetes. 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