{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:41:01Z","timestamp":1769560861080,"version":"3.49.0"},"reference-count":15,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>\n                    Lipoid adrenal hyperplasia (LAH) is a rare severe form of congenital adrenal hyperplasia, which is caused by mutations in the\n                    <jats:italic>STAR<\/jats:italic>\n                    gene (8p11.2), encoding the transport protein StAR. The defect of the StAR protein leads to a total disruption of adrenal and gonadal steroidogenesis. The division into the classic form of the disease, in which all steroidogenesis is disrupted, and the non-classic, in which only adrenal steroidogenesis is usually disrupted, is a generally accepted classification of LAH. We report two cases of patients with clinical and laboratory data indicating a non-classic LAH. Both patients with 46,XY karyotype presented late (at 5 and 3 years) manifestation of clinical symptoms and had normal male external genitalia. Homozygous mutation p.R188C in one patient and compound heterozygous mutations p.R188C and p.R272H in the other were identified by molecular genetic assay.\n                    <jats:italic>STAR<\/jats:italic>\n                    genetic testing allowed to diagnose non-classic LAH in differential diagnosis of hypocorticism.\n                  <\/jats:p>","DOI":"10.14341\/probl13589","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:17:04Z","timestamp":1769516224000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Non-classic lipoid adrenal hyperplasia: clinical cases report"],"prefix":"10.14341","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3723-8765","authenticated-orcid":true,"given":"I. G.","family":"Sichinava","sequence":"first","affiliation":[{"name":"Pirogov Russian National Research Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-1245","authenticated-orcid":true,"given":"E. S.","family":"Demina","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University;\r\nRussian Children\u2019s Clinical Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6659-5600","authenticated-orcid":true,"given":"E. M.","family":"Sharibzhanova","sequence":"additional","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-1440","authenticated-orcid":true,"given":"L. S.","family":"Sozaeva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-2378","authenticated-orcid":true,"given":"E. E.","family":"Petryaykina","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University;\r\nRussian Children\u2019s Clinical Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-4841","authenticated-orcid":true,"given":"A. N.","family":"Tiulpakov","sequence":"additional","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital;\r\nResearch Center for Medical Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Miller WL. 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