{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:07:04Z","timestamp":1779307624535,"version":"3.51.4"},"reference-count":5,"publisher":"Endocrinology Research Centre","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"\n BACKGROUND<\/jats:bold>\n : Autoimmune thyroid diseases (AITD) result from immune system dysregulation. Among them are Hashimoto\u2019s thyroiditis, Graves\u2019 disease, etc. Approximately 3% of patients with Hashimoto\u2019s thyroiditis may develop orbitopathy. Thyroid eye disease (TED), is an organ-specific autoimmune reaction that primarily affects the eyes and surrounding tissues. The aim of this case report is to present a rare condition of a female patient who was diagnosed with exophthalmos nine years after being diagnosed with Hashimoto\u2019s thyroiditis.\n <\/jats:p>\n \n CASE REPORT<\/jats:bold>\n : A 45-year-old woman presented to our department with Hashimoto\u2019s thyroiditis and hypothyroidism. Her medical history revealed that she was diagnosed with HT nine years ago and had been receiving L-thyroxine treatment throughout this period. However, her condition remained uncompensated, and in the past year, she developed bilateral exophthalmos as a complication.\n <\/jats:p>\n \n CONCLUSION<\/jats:bold>\n : Exophthalmos is generally more strongly associated with Graves\u2019 disease, a form of hyperthyroidism. However, it can also occur in some patients with Hashimoto\u2019s thyroiditis, although it is less common.\n <\/jats:p>","DOI":"10.14341\/probl13597","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:22:08Z","timestamp":1779304928000},"page":"40-42","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of a Patient with Thyroid eye disease Induced by Hashimoto\u2019s Thyroiditis"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8697-3042","authenticated-orcid":true,"given":"M. H.","family":"Khaskhazyan","sequence":"first","affiliation":[{"name":"Medline clinic and National Institute of Health Named After Academician S. Avdalbekyan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9918-7844","authenticated-orcid":true,"given":"D. K.","family":"Shaghbatyan","sequence":"additional","affiliation":[{"name":"Ophthalmological center after S. V. Malayan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9395-3369","authenticated-orcid":true,"given":"T. A.","family":"Ambartsumyan","sequence":"additional","affiliation":[{"name":"Yerevan State Medical University after Mkhitar Heratsi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4049-6549","authenticated-orcid":true,"given":"R. S.","family":"Mnatsakanyan","sequence":"additional","affiliation":[{"name":"Erebuni medical center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4941-2188","authenticated-orcid":true,"given":"R. T.","family":"Shahbazyan","sequence":"additional","affiliation":[{"name":"Erebuni medical center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Alessandro Antonelli, Silvia Martina Ferrari, Alda Corrado, Andrea Di Domenicantonio, Poupak Fallahi. Autoimmune thyroid disorders. Elsevier, Volume 14,Issue 2, February 2015, Pages 174-180.","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Macovei ML, Azis \u0170. A case report of a patient with severe thyroid eye disease. Rom J Ophthalmol. 2022 Apr-Jun;66(2):153-157. doi: 10.22336\/rjo.2022.30. PMID: 35935091; PMCID: PMC9289779.","DOI":"10.22336\/rjo.2022.30"},{"key":"ref3","unstructured":""},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Bartalena L, Kahaly GJ, Baldeschi L, Dayan CM, Eckstein A, Marcocci C, Marin\u00f2 M, Vaidya B, Wiersinga WM; EUGOGO \u2020. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. Eur J Endocrinol. 2021 Aug 27;185(4):G43-G67. doi: 10.1530\/EJE-21-0479. PMID: 34297684.","DOI":"10.1530\/EJE-21-0479"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Karpecki, Paul M.Kanski\u2019s: Clinical Ophthalmology, A Systematic Approach, Brad Bowling 8th ed., : October 2015. , 92(10):p e386, DOI: 10.1097","DOI":"10.1097\/OPX.0000000000000737"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13597\/10986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:22:13Z","timestamp":1779304933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,20]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13597","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}