{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:29:05Z","timestamp":1773235745136,"version":"3.50.1"},"reference-count":10,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Non-healing ulcers pose a serious problem for public health due to the high cost of treatment, prolonged disability of patients, and low efficacy of therapy. They are the leading cause of non-traumatic lower limb amputations.<\/jats:p>\n                  <jats:p>The development of innovative bioengineering products is a significant step in the treatment of non-healing diabetic foot ulcers. One such product is a tissue-engineered acellular product made from highly regenerative human umbilical cord biomaterial. It contains growth factors, cytokines, and components of the extracellular matrix of Wharton\u2019s jelly, which accelerates wound healing.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>THE AIM<\/jats:bold>\n                    \u00a0of this clinical study is to evaluate the safety and efficacy of a tissue-engineered acellular product from Wharton\u2019s jelly of the umbilical cord for the treatment of chronic non-healing lower limb ulcers in patients with diabetic foot syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    \u00a0a 60-year-old woman diagnosed with type 2 diabetes mellitus had chronic ulcers that had not responded to standard treatment for more than a year and a half. She was observed for 4 weeks in August 2024. As a result of the local application of an acellular product from human umbilical cord, signs of reduction in wound size and their complete healing were noted 4 weeks after the start of observation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    \u00a0clinical observation has demonstrated the safety and efficacy of the acellular product from human umbilical cord for the treatment of chronic non-healing ulcers of diabetic origin.\n                  <\/jats:p>","DOI":"10.14341\/probl13615","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:22:48Z","timestamp":1773163368000},"page":"99-107","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Use of human umbilical cord acellular matrix for soft tissue defects in patient with diabetic foot syndrome (case report)"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-1983","authenticated-orcid":true,"given":"S. V.","family":"Chebotarev","sequence":"first","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-3056","authenticated-orcid":true,"given":"D. V.","family":"Tovpeko","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-4872","authenticated-orcid":true,"given":"L. I.","family":"Kalyuzhnaya","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-2698","authenticated-orcid":true,"given":"M. E.","family":"Kotova","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-5864","authenticated-orcid":true,"given":"A. A.","family":"Kondratenko","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy;\r\nSaint Petersburg State Pediatric Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-7622","authenticated-orcid":true,"given":"D. A.","family":"Volov","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-3316","authenticated-orcid":true,"given":"V. V.","family":"Khominets","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-3782","authenticated-orcid":true,"given":"V. E.","family":"Chernov","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4716-809X","authenticated-orcid":true,"given":"D. A.","family":"Zemlyanoy","sequence":"additional","affiliation":[{"name":"Saint Petersburg State Pediatric Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-0941","authenticated-orcid":true,"given":"V. V.","family":"Salukhov","sequence":"additional","affiliation":[{"name":"S.M. Kirov Military Medical Academy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"ref1","unstructured":"International Working Group on the Diabetic Foot (IWGDF) Guidance. DiabetesMetabResRev. 2019;36"},{"key":"ref2","unstructured":"International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: International Diabetes Federation; 2021. 168 p"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Armstrong DG, Boulton AJ, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 2017;376(24):2367-2375","DOI":"10.1056\/NEJMra1615439"},{"key":"ref4","unstructured":"Ma Z, Wang P, Zhan L. The application of tissue-engineered biomaterials in wound healing. Int J BiolMacromol. 2021;184:340-356"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kondratenko AA, Tovpeko DV, Volov DA, et al. Decellularized Umbilical Cord as a Scaffold to Support Healing of Full-Thickness Wounds. Biomimetics. 2024;7(9):405. doi: https:\/\/doi.org\/10.3390\/biomimetics9070405","DOI":"10.3390\/biomimetics9070405"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Martinez-Zapata MJ, Mart\u00ed-Carvajal AJ, Sol\u00e0 I, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev. 2016;5:CD006899","DOI":"10.1002\/14651858.CD006899.pub3"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Badiavas EV, Falanga V. Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol. 2003;139(4):510-516","DOI":"10.1001\/archderm.139.4.510"},{"key":"ref8","unstructured":"Frykberg RG, Gibbons GW. The Diabetic Foot: Evaluation and Management. Curr Treat Options Cardiovasc Med. 2006;8(2):151-164"},{"key":"ref9","unstructured":"PatentRUS \u21162816034 \/ 25.03.2024. Khominets VV, Kalyuzhnaya-Zemlyanaya LI, Kondratenko AA, Tovpeko DV, Zemlyanoy DA, Volov DA, Chebotarev SV. Method of using a cell-free lyophilized product from the human umbilical cord for wound healing. (in Russ.)"},{"key":"ref10","unstructured":"PatentRUS \u21162795904 \/ 15.05.2023. Kalyuzhnaya-Zemlyanaya LI, Tovpeko DV, Kondratenko AA, Zemlyanoy DA, Chernov VE, Chebotarev SV, Volov DA. Method of manufacturing a cell-free matrix from the human umbilical cord to create a highly regenerative wound covering. (in Russ.)"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13615\/10969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:22:56Z","timestamp":1773163376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,7]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13615","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,7]]}}}