{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:13:44Z","timestamp":1789578824841,"version":"build-2803163510"},"reference-count":23,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>\n                    <jats:bold>\n                      BACKGROUND:\n                      <jats:italic>\u00a0<\/jats:italic>\n                    <\/jats:bold>\n                    Adrenal incidentalomas are common, with a detection rate of up to 7% in patients over 70 years of age. Of these, up to 25% are functionally active, leading to the development of severe clinical manifestations. Challenges of insufficient diagnosis and a lack of a personalized approach to the management of such patients persist. To overcome these challenges, the use of CT image analysis is proposed to develop criteria for non-invasive diagnosis, which is a pathway towards improving personalized patient management.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      AIM:\n                      <jats:italic>\u00a0<\/jats:italic>\n                    <\/jats:bold>\n                    Analysis of statistically significant correlations between clinical-laboratory parameters and contrast-enhanced (CE) CT imaging features of adrenal adenomas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      MATERIALS AND METHODS:\n                      <jats:italic>\u00a0<\/jats:italic>\n                    <\/jats:bold>\n                    A single-center, non-comparative, cross-sectional retrospective study analyzed preoperative images from four-phase CECT of adrenal adenomas. Hormonal workup included the determination of aldosterone, renin, cortisol levels during an overnight dexamethasone suppression test (DST), adrenocorticotropic hormone (ACTH), 24-hour urinary free cortisol (UFC); potassium and creatinine levels were also assessed. Clinical data included arterial hypertension, impaired carbohydrate metabolism, dyslipidemia, hypokalemia, and renal dysfunction. A comparative and correlation analysis was performed between clinical-laboratory parameters and CECT characteristics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      RESULTS:\n                      <jats:italic>\u00a0<\/jats:italic>\n                    <\/jats:bold>\n                    The study included 254 patients. Hormonal activity was detected in 226 (89.0%) patients; 28 (11.0%) patients had non-functioning adenomas. Hormonally inactive adenomas were characterized by larger size (43.0 mm [32.7; 51.2] vs. 29.0 mm [20; 36], p&lt;0.001), higher native density (41.0 HU [36.0; 47.2] vs. 25.0 HU [12.0; 37.0], p&lt;0.001), and lower venous phase contrast enhancement (141.6% vs. 283.7%, p=0.001). In primary aldosteronism (PA), adenomas were significantly smaller (20.0 mm [16.8; 25.0]) and had lower native density (14.0 HU [4.0; 24.0]) compared to cortisol-producing tumors (34.0 mm [30.0; 38.0], 35.5 HU [30.0; 44.0], p&lt;0.001). The presence of calcifications was more frequently observed in cortisol hypersecretion compared to PA (p=0.011). Correlation analysis revealed negative associations between adenoma size and levels of aldosterone (r=\u20130.504, p&lt;0.001) and ACTH (r=\u20130.419, p&lt;0.001), and positive associations with post-DST cortisol levels (r=0.500, p&lt;0.001), renin (r = 0.454, p&lt;0.001), and potassium (r=0.458, p&lt;0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      CONCLUSION:\n                      <jats:italic>\u00a0<\/jats:italic>\n                    <\/jats:bold>\n                    CT characteristics of adrenal adenomas vary depending on hormonal activity, type of secretion, and clinical manifestations.\n                  <\/jats:p>","DOI":"10.14341\/probl13670","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:22:48Z","timestamp":1773163368000},"page":"23-37","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Modern capabilities of contrast-enhanced computed tomography in the diagnosis of adrenal adenomas"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-9454","authenticated-orcid":true,"given":"N. 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M.","family":"Platonova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8702","authenticated-orcid":true,"given":"E. A.","family":"Troshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-7877","authenticated-orcid":true,"given":"G. A.","family":"Melnichenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-9742","authenticated-orcid":true,"given":"N. 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