{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:00:40Z","timestamp":1773205240304,"version":"3.50.1"},"reference-count":8,"publisher":"Endocrinology Research Centre","issue":"5","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    <jats:bold\/>\n                    Adrenal lesion characterization remains a diagnostic challenge due to overlapping imaging features. Dual-energy CT (DECT) shows promise for identifying image-based biomarkers but requires further validation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>AIM:<\/jats:bold>\n                    To evaluate the diagnostic utility of DECT in differentiating adrenal lesions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MATERIALS AND METHODS:<\/jats:bold>\n                    This retrospective single-center study analyzed DECT data. Parameters from 40\/70\/80 keV virtual monoenergetic images and water-iodine\/fat-iodine\/water-fat decomposition maps were evaluated. Statistical analysis included Kruskal-Wallis, Mann-Whitney U, ROC tests.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    The cohort included 74 patients (median age 46.0 years (39.3\u201357.9), 48 women). For ACC and adenomas differentiation, mean 70 keV delayed phase attenuation showed the highest discriminative value (AUC=0.92; 95% CI: 0.81\u20131.00; p=0.001). For ACC and pheochromocytomas, standard deviation delayed phase water concentration (water-fat maps) achieved the highest diagnostic performance (AUC=0.89; 95% CI: 0.79\u20130.97; p=0.001). Maximum 70 keV delayed phase attenuation best distinguished adenomas from pheochromocytomas (AUC=0.82; 95% CI: 0.71\u20130.92; p&lt;0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    DECT has proven its diagnostic value in the differential diagnosis of adrenal lesions.\n                  <\/jats:p>","DOI":"10.14341\/probl13671","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T08:51:37Z","timestamp":1764838297000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Dual-energy CT for differential diagnosis of adrenal lesions"],"prefix":"10.14341","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-9454","authenticated-orcid":true,"given":"N. V.","family":"Tarbaeva","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8035-676X","authenticated-orcid":true,"given":"A. V.","family":"Manaev","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4475-8752","authenticated-orcid":true,"given":"A. Yu.","family":"Kornelyuk","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-008X","authenticated-orcid":true,"given":"M. V.","family":"Godzenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-7809","authenticated-orcid":true,"given":"K. V.","family":"Ivaschenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5592-4794","authenticated-orcid":true,"given":"A.","family":"Chevais","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-7877","authenticated-orcid":true,"given":"G. A.","family":"Melnichenk\u043e","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-9742","authenticated-orcid":true,"given":"N. G.","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mayo-Smith WW, Song JH, Boland GL, et al. Management of Incidental Adrenal Masses: A White Paper of the ACR Incidental Findings Committee. J Am Coll Radiol 2017;14(8):1038\u20131044","DOI":"10.1016\/j.jacr.2017.05.001"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Albano D, Agnello F, Midiri F, et al. Imaging features of adrenal masses. Insights Imaging. 2019;10:1\u201316. doi: https:\/\/doi.org\/10.1186\/s13244-019-0688-8","DOI":"10.1186\/s13244-019-0688-8"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Hindman NM, Megibow AJ. One-stop shopping: dual-energy CT for the confident diagnosis of adrenal adenomas. Radiology. 2020;296(2):333\u2013334","DOI":"10.1148\/radiol.2020201718"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Nagayama Y, Inoue T, Oda S, et al. Adrenal adenomas versus metastases: diagnostic performance of dual-energy spectral CT virtual noncontrast imaging and iodine maps. Radiology. 2020;296(3):324\u2013332","DOI":"10.1148\/radiol.2020192227"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Loonis A-ST, Dohan A, Goudot G, et al. Dual energy\u2013derived metrics for differentiating adrenal adenomas from nonadenomas on single-phase contrast-enhanced CT. AJR Am J Roentgenol. 2023;220(5):693\u2013704","DOI":"10.2214\/AJR.22.28323"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Wang Y-L, Li J, Zhang Y, et al. Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? 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Quant Imaging Med Surg. 2021;12(2):1149\u20131162. doi: https:\/\/doi.org\/10.21037\/qims-21-708","DOI":"10.21037\/qims-21-708"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13671\/10908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:40:30Z","timestamp":1769686830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,2]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13671","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,2]]}}}