{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:04:49Z","timestamp":1787022289799,"version":"build-2736575974"},"reference-count":64,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>This article presents an overview of current research on determining target blood levels of vitamin D. It examines the biochemical and metabolic properties of vitamin D, as well as the challenges of standardizing 25(OH)D measurements and the variability of threshold values across populations. It discusses ambiguities in scientific data and the need to consider individual factors when interpreting vitamin D levels. This review is unique in its comprehensive approach to analyzing the effects of vitamin D not only on bone health but also on immune and metabolic functions, which broadens ever evolving understanding of the clinical significance of vitamin D. This work emphasizes the importance of personalized recommendations for vitamin D dosing and prescription based on current clinical data and scientific standards. Performed analysis highlights the need for personalized vitamin D supplementation to reach and maintain blood levels between 30 and 60 ng\/mL, noting that higher levels might be necessary for people with genetic or acquired resistance. These insights substantiate the development of evidence-based, personalized clinical strategies for the prevention and treatment of vitamin D deficiency-related disorders. The synthesized data offer significant implications for advancing research and clinical practice in endocrinology, obstetrics, dermatology, neurology and immunology.<\/jats:p>","DOI":"10.14341\/probl13687","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:17:04Z","timestamp":1769516224000},"page":"40-49","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Optimal serum 25(OH)D levels in relation to musculoskeletal, metabolic, neurological, autoimmune and infectious diseases"],"prefix":"10.14341","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8702","authenticated-orcid":true,"given":"E. A.","family":"Troshina","sequence":"first","affiliation":[{"name":"Federal State Budgetary Institution \u00abI.I. Dedov National Medical Research Center of Endocrinology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-466X","authenticated-orcid":true,"given":"E. A.","family":"Pigarova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abI.I. Dedov National Medical Research Center of Endocrinology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-0123","authenticated-orcid":true,"given":"T. L.","family":"Karonova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Center of Endocrinology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-4619","authenticated-orcid":true,"given":"F. Kh.","family":"Dzgoeva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abI.I. Dedov National Medical Research Center of Endocrinology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-0466","authenticated-orcid":true,"given":"V. E.","family":"Radzinskiy","sequence":"additional","affiliation":[{"name":"Patrice Lumumba Peoples\u2019 Friendship University of Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-2823","authenticated-orcid":true,"given":"I. I.","family":"Baranov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abAcademician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-0614","authenticated-orcid":true,"given":"O. M.","family":"Lesnyak","sequence":"additional","affiliation":[{"name":"State Budgetary Educational Institution of Higher Professional Education \u00abNorth-Western State Medical University named after I.I. Mechnikov National Research Medical University of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-2290","authenticated-orcid":true,"given":"Yu. E.","family":"Dobrokhotova","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-3767","authenticated-orcid":true,"given":"I. V.","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"International Association of Gynecologists, Endocrinologists, and Therapists (IAGET)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-788X","authenticated-orcid":true,"given":"N. V.","family":"Zarochentseva","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u00abMONIKI\u00bb)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-661X","authenticated-orcid":true,"given":"G. R.","family":"Bayramova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abAcademician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology\u00bb of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-2474","authenticated-orcid":true,"given":"O. A.","family":"Radaeva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-6094","authenticated-orcid":true,"given":"E. V.","family":"Ekusheva","sequence":"additional","affiliation":[{"name":"Academy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-8075","authenticated-orcid":true,"given":"L. A.","family":"Suplotova","sequence":"additional","affiliation":[{"name":"Tyumen State Medical University of the Russian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-0617","authenticated-orcid":true,"given":"E. V.","family":"Matushevskaya","sequence":"additional","affiliation":[{"name":"Academy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5458","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lips P, de Jongh RT, van Schoor NM. Trends in Vitamin D Status Around the World. JBMR Plus. 2021;5(12):e10585. doi: https:\/\/doi.org\/10.1002\/jbm4.10585","DOI":"10.1002\/jbm4.10585"},{"key":"ref2","unstructured":"Deficit vitamina D u vzroslyh. Klinicheskie rekomendacii. RAE, 2021 (In Russ.). https:\/\/www.endocrincentr.ru\/sites\/default\/files\/specialists\/science\/clinic-recomendations\/kr_deficit_vitamina_d_2021.pdf"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Grant WB, Al Anouti F, Boucher BJ, Dursun E, Gezen-Ak D, et al. A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health. Nutrients. 2022;14(3):639. doi: https:\/\/doi.org\/10.3390\/nu14030639","DOI":"10.3390\/nu14030639"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med. 2008;29:361\u20138","DOI":"10.1016\/j.mam.2008.08.008"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Cashman KD, Kiely M. Towards prevention of vitamin D deficiency and beyond\u2014knowledge gaps and research needs in vitamin D nutrition and public health. Br J Nutr. 2011;106:1617\u201327","DOI":"10.1017\/S0007114511004995"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Sempos CT, Vesper HW, Phinney KW, Thienpont LM, Coates PM; Vitamin D Standardization Program (VDSP). Vitamin D status as an international issue: national surveys and the problem of standardization. Scand J Clin Lab Invest Suppl. 2012;243:32-40. doi: https:\/\/doi.org\/10.3109\/00365513.2012.681935","DOI":"10.1096\/fasebj.26.1_supplement.41.1"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Cashman KD, Dowling KG, \u0160krab\u00e1kov\u00e1 Z, Gonzalez-Gross M, Valtue\u00f1a J, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033-44. doi: https:\/\/doi.org\/10.3945\/ajcn.115.120873.","DOI":"10.3945\/ajcn.115.120873"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Karonova TL, et al. the prevalence of vitamin d deficiency in the northwestern region of the russian federation among the residents of st. petersburg and petrozavodsk. Osteoporosis and Bone Diseases. 2013;16(3):3-7. (In Russ.) doi: https:\/\/doi.org\/10.14341\/osteo201333-7","DOI":"10.14341\/osteo201333-7"},{"key":"ref9","unstructured":"Markova TN, et al. Prevalence of vitamin D deficiency and risk factors for osteoporosis in young adults. Bulletin of the Chuvash University. 2012;234(3):441-446 (In Russ.)"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Agureeva OV, et al. Analiz urovnya vitamina D v syvorotke krovi patsientov v Rostovskoy oblasti. Osteoporosis and Bone Diseases. 2016;19(2):47-47. (In Russ.) doi: https:\/\/doi.org\/10.14341\/osteo2016247-47","DOI":"10.14341\/osteo2016247-47"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Borisenko EP, Romantsova EB, Babtseva AF. Vitamin D duration in children and adults in the Amur region. Bulletin of Respiratory Physiology and Pathology. 2016;(60):57\u201361. doi: https:\/\/doi.org\/10.12737\/20121","DOI":"10.12737\/20121"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Malyavskaya SI, et al. 25(OH)D levels in the population of Arkhangelsk city in different age groups. Ekologiya cheloveka (Human Ecology). 2018;25(1):60-64. (In Russ.) doi: https:\/\/doi.org\/10.33396\/1728-0869-2018-1-60-64","DOI":"10.33396\/1728-0869-2018-1-60-64"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Nurlygayanov RZ, et al. The level of vitamin D in people older than 50 years residing in the republic of Bashkortostan in the period of maximum insolation. Osteoporosis and Bone Diseases. 2015;18(1):7-9. (In Russ.) doi: https:\/\/doi.org\/10.14341\/osteo201517-9","DOI":"10.14341\/osteo201517-9"},{"key":"ref14","unstructured":"Spasich TA, et al. Hygienic significance of vitamin D deficiency in the population of the Irkutsk region and ways of its prevention. Acta Biomedica Scientifica. 2014;6:100 (In Russ.) URL: https:\/\/cyberleninka.ru\/article\/n\/gigienicheskoe-znachenie-defitsita-vitamina-d-u-naseleniya-irkutskoy-oblasti-i-puti-ego-profilaktiki (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 14.11.2025)."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Suplotova LA, et al. The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation. Terapevticheskii arkhiv. 2021;93(10):1209-1216. (In Russ.) doi: https:\/\/doi.org\/10.26442\/00403660.2021.10.201071","DOI":"10.26442\/00403660.2021.10.201071"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Khazova EL, et al. Season fluctuations of level of 25-hydroxycholecalciferol in pregnant women living in Saint Petersburg. Gynecology. 2015;17(4):38-42 (In Russ.)","DOI":"10.26442\/2079-5831_17.4.38-42"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Karonova TL, Andreeva AT, Golovatyuk KA, Bykova ES, Skibo II, Grineva EN, Shlyakhto EV. SARS-CoV-2 morbidity depending on vitamin D status. Problems of Endocrinology. 2021;67(5):20-28. (In Russ.) doi: https:\/\/doi.org\/10.14341\/probl12820","DOI":"10.14341\/probl12820"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Saponaro F, Saba A, Zucchi R. An Update on Vitamin D Metabolism. Int J Mol Sci. 2020;21(18):6573. doi: https:\/\/doi.org\/10.3390\/ijms21186573","DOI":"10.3390\/ijms21186573"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Jones G. Extrarenal vitamin D activation and interactions between vitamin D\u2082, vitamin D\u2083, and vitamin D analogs. Annu Rev Nutr. 2013;33:23-44. doi: https:\/\/doi.org\/10.1146\/annurev-nutr-071812-161203","DOI":"10.1146\/annurev-nutr-071812-161203"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Lai YH, Fang TC. The pleiotropic effect of vitamin d. ISRN Nephrol. 2013; 2013:898125. doi: https:\/\/doi.org\/10.5402\/2013\/898125","DOI":"10.5402\/2013\/898125"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125-135. doi: https:\/\/doi.org\/10.1016\/j.jsbmb.2017.01.021","DOI":"10.1016\/j.jsbmb.2017.01.021"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Wimalawansa SJ. Infections and Autoimmunity-The Immune System and Vitamin D: A Systematic Review. Nutrients. 2023;15(17):3842. doi: https:\/\/doi.org\/10.3390\/nu15173842","DOI":"10.3390\/nu15173842"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Dragomir RE, Toader OD, Gheoca Mutu DE, St\u0103nculescu RV. The Key Role of Vitamin D in Female Reproductive Health: A Narrative Review. Cureus. 2024;16(7):e65560. doi: https:\/\/doi.org\/10.7759\/cureus.65560","DOI":"10.7759\/cureus.65560"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. doi: https:\/\/doi.org\/10.1093\/ajcn\/84.1.18","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"McDonnell SL, Baggerly LL, French CB, Heaney RP, Gorham ED, Holick MF, Scragg R, Garland CF. Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng\/ml than in NHANES cohort with median of 22 ng\/ml. J Steroid Biochem Mol Biol. 2016;155(Pt B):239-44. doi: https:\/\/doi.org\/10.1016\/j.jsbmb.2015.06.013","DOI":"10.1016\/j.jsbmb.2015.06.013"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Scragg R, et.al. A Randomized Clinical Trial. JAMA Cardiol. 2017;2(6):608-616. doi: https:\/\/doi.org\/10.1001\/jamacardio.2017.0175","DOI":"10.1001\/jamacardio.2017.0175"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Khaw KT, et al. Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol. 2017;5(6):438-447. doi: https:\/\/doi.org\/10.1016\/S2213-8587(17)30103-1","DOI":"10.1016\/S2213-8587(17)30103-1"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Manson JE et al; VITAL Research Group. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2019;380(1):33-44. doi: https:\/\/doi.org\/10.1056\/NEJMoa1809944","DOI":"10.1056\/NEJMoa1809944"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Lappe J et al. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017;317(12):1234-1243. doi: https:\/\/doi.org\/10.1001\/jama.2017.2115","DOI":"10.1001\/jama.2017.2115"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Pittas AG et al; D2d Research Group. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019;381(6):520-530. doi: https:\/\/doi.org\/10.1056\/NEJMoa1900906","DOI":"10.1056\/NEJMoa1900906"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Bischoff-Ferrari HA, et al.; DO-HEALTH Research Group. DO-HEALTH: Vitamin D3 - Omega-3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors. Contemp Clin Trials. 2021; 100:106124. doi: https:\/\/doi.org\/10.1016\/j.cct.2020.106124","DOI":"10.1016\/j.cct.2020.106124"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Pilz S, Trummer C, Theiler-Schwetz V, Gr\u00fcbler MR, Verheyen ND, et al. Critical Appraisal of Large Vitamin D Randomized Controlled Trials. Nutrients. 2022;14(2):303. doi: https:\/\/doi.org\/10.3390\/nu14020303","DOI":"10.3390\/nu14020303"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Carmel AS, Shieh A, Bang H, Bockman RS. The 25(OH)D level needed to maintain a favorable bisphosphonate response is \u226533 ng\/ml. Osteoporos Int. 2012;23(10):2479-87. doi: https:\/\/doi.org\/10.1007\/s00198-011-1868-7","DOI":"10.1007\/s00198-011-1868-7"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One. 2020;15(9):e0239252. doi: https:\/\/doi.org\/10.1371\/journal.pone.0239252","DOI":"10.1371\/journal.pone.0239252"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022;37(4):853-861. doi: https:\/\/doi.org\/10.1007\/s11606-021-07170-0","DOI":"10.1007\/s11606-021-07170-0"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Lemke D, Klement RJ, Schweiger F, Schweiger B, Spitz J. Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol. Front Immunol. 2021;12:655739. doi: https:\/\/doi.org\/10.3389\/fimmu.2021.655739","DOI":"10.3389\/fimmu.2021.655739"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Wimalawansa SJ. Infections and Autoimmunity-The Immune System and Vitamin D: A Systematic Review. Nutrients. 2023;15(17):3842. doi: https:\/\/doi.org\/10.3390\/nu15173842","DOI":"10.3390\/nu15173842"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Wimalawansa SJ. Non-musculoskeletal benefits of vitamin D. J Steroid Biochem Mol Biol. 2018;175:60-81. doi: https:\/\/doi.org\/10.1016\/j.jsbmb.2016.09.016","DOI":"10.1016\/j.jsbmb.2016.09.016"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer\u2019s disease: A meta-analysis of dose-response. Nutr Neurosci. 2019;22(11):750-759. doi: https:\/\/doi.org\/10.1080\/1028415X.2018.1436639","DOI":"10.1080\/1028415X.2018.1436639"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"McDonnell SL, Baggerly CA, French CB, Baggerly LL, Garland CF, Gorham ED, Hollis BW, Trump DL, Lappe JM. Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations \u226560 vs <20 ng\/ml (150 vs 50 nmol\/L): Pooled analysis of two randomized trials and a prospective cohort. PLoS One. 2018;13(6):e0199265. doi: https:\/\/doi.org\/10.1371\/journal.pone.0199265","DOI":"10.1371\/journal.pone.0199265"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, et al. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. J Natl Cancer Inst. 2019;111(2):158-169. doi: https:\/\/doi.org\/10.1093\/jnci\/djy087","DOI":"10.1093\/jnci\/djy087"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Shirvani A, Kalajian TA, Song A, Holick MF. Disassociation of Vitamin D\u2019s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial. Sci Rep. 2019;9(1):17685. doi: https:\/\/doi.org\/10.1038\/s41598-019-53864-1","DOI":"10.1038\/s41598-019-53864-1"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Li Y, Tong CH, Rowland CM, Radcliff J, Bare LA, McPhaul MJ, Devlin JJ. Association of changes in lipid levels with changes in vitamin D levels in a real-world setting. Sci Rep. 2021;11(1):21536. doi: https:\/\/doi.org\/10.1038\/s41598-021-01064-1","DOI":"10.1038\/s41598-021-01064-1"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Dai L, Liu M, Chen L. Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease. Front Nutr. 2021;8:740855. doi: https:\/\/doi.org\/10.3389\/fnut.2021.740855","DOI":"10.3389\/fnut.2021.740855"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Mirhosseini N, Vatanparast H, Kimball SM. The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements. Nutrients. 2017;9:1244. doi: https:\/\/doi.org\/10.3390\/nu9111244","DOI":"10.3390\/nu9111244"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Novotny DA, Zhukova NG, Shperling LP, Stolyarova VA, Zhukova IA, Agasheva AE, Shtaymets SV, Druzhinina OA. Vitamin D (steroid hormone) and diseases of the nervous system (literature review). Siberian Scientific Medical Journal. 2020;40(5):24-37 (In Russ.) doi: https:\/\/doi.org\/10.15372\/SSMJ20200503","DOI":"10.15372\/SSMJ20200503"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis. Pain Physician. 2016;19(7): 415-27. PMID: 27676659.","DOI":"10.36076\/ppj\/2016.19.415"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Di Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano S, Mele C, Scacchi M, Aimaretti G, Colao A, Marzullo P. Vitamin D and Neurological Diseases: An Endocrine View. Int J Mol Sci. 2017;18(11):2482. doi: https:\/\/doi.org\/10.3390\/ijms1811248","DOI":"10.3390\/ijms18112482"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Nerhus M, Berg AO, Simonsen C, Haram M, Haatveit B, et al. Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders. J Clin Psychiatry. 2017;78(7):e750-e757. doi: https:\/\/doi.org\/10.4088\/JCP.16m10880","DOI":"10.4088\/JCP.16m10880"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Gromova OA, Torshin IYu, Putilina MV, Sardaryan IS, Fedotova LE, Limanova OA. Nociception: the role of vitamin D. Neurology, neuropsychiatry, psychosomatics. 2021;13(1):145-153 (In Russ.) doi: https:\/\/doi.org\/10.14412\/2074-2711-2021-1-145-153","DOI":"10.14412\/2074-2711-2021-1-145-153"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Prono F, Bernardi K, Ferri R, Bruni O. The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Int. J. Mol. Sci. 2022;23:1430. doi: https:\/\/doi.org\/10.3390\/ijms23031430","DOI":"10.3390\/ijms23031430"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Nowaczewska M, Wici\u0144ski M, Osi\u0144ski S, Ka\u017amierczak H. The Role of Vitamin D in Primary Headache-from Potential Mechanism to Treatment. Nutrients. 2020;12(1):243. doi: https:\/\/doi.org\/10.3390\/nu12010243","DOI":"10.3390\/nu12010243"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Dell\u2019Isola GB, Tulli E, Sica R, Vinti V, Mencaroni E. et al. The Vitamin D Role in Preventing Primary Headache in Adult and Pediatric Population. J. Clin. Med. 2021;10:5983. doi: https:\/\/doi.org\/10.3390\/jcm10245983.","DOI":"10.3390\/jcm10245983"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021 Dec;50:784-788. doi: https:\/\/doi.org\/10.1016\/j.ajem.2021.07.062","DOI":"10.1016\/j.ajem.2021.07.062"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"McDonnell SL, Baggerly KA, Baggerly CA, Aliano JL, French CB, et al. Maternal 25(OH)D concentrations \u226540 ng\/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center. PLoS One. 2017;12(7):e0180483. doi: https:\/\/doi.org\/10.1371\/journal.pone.0180483","DOI":"10.1371\/journal.pone.0180483"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Mirzakhani H, Litonjua AA, McElrath TF, O\u2019Connor G, Lee-Parritz A, et al. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016;126(12):4702-4715. doi: https:\/\/doi.org\/10.1172\/JCI89031","DOI":"10.1172\/JCI89031"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Maltseva LI, Vasilyeva EN, Denisova TG, Garifullova YuV. The influence of vitamin D on the course and outcomes of pregnancy in women. Practical medicine. 2020;18(2):2-20 (In Russ.) doi: https:\/\/doi.org\/10.32000\/2072-1757-2020-2-12-20","DOI":"10.32000\/2072-1757-2020-2-12-20"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Dawson-Hughes B, Staten MA, Knowler WC, Nelson J, Vickery EM, et al. Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study. Diabetes Care. 2020;43(12):2916-2922. doi: https:\/\/doi.org\/10.2337\/dc20-1765","DOI":"10.2337\/dc20-1765"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Karonova TL, Andreeva AT, Golovatyuk KA, Bykova ES, Skibo II, Grineva EN, Shlyakhto EV. SARS-CoV-2 morbidity depending on vitamin D status. Problems of Endocrinology. 2021;67(5):20-28. (In Russ.) doi: https:\/\/doi.org\/10.14341\/probl12820","DOI":"10.14341\/probl12820"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am. J. Clin. Nutr. 1995;61:638S\u2013645S. doi: https:\/\/doi.org\/10.1093\/ajcn\/61.3.638S","DOI":"10.1093\/ajcn\/61.3.638S"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Kimball SM, Mirhosseini N, Holick MF. Evaluation of vitamin D3 intakes up to 15,000 international units\/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol\/L on calcium metabolism in a community setting. Dermatoendocrinology. 2017;9:e1300213. doi: https:\/\/doi.org\/10.1080\/19381980.2017.1300213","DOI":"10.1080\/19381980.2017.1300213"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven-year experience. J. Steroid Biochem. Mol. Biol. 2019;189:228\u2013239. doi: https:\/\/doi.org\/10.1016\/j.jsbmb.2018.12.010","DOI":"10.1016\/j.jsbmb.2018.12.010"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Rozhinskaya L.Y., Pigarova E.A., Bagretsova A.A., Verbovoy A.F., Kondratyeva N.G., Vasilevskaya O.A., Vasilyuk V.B., Manko M.V., Shunkov V.B., Grebennikova T.A. High-doses of cholecalciferol for vitamin D deficiency treatment: results of an open-label, multicenter, comparative, randomized trial. Osteoporosis and Bone Diseases. 2020;23(3):4-16. (In Russ.) doi: https:\/\/doi.org\/10.14341\/osteo12697","DOI":"10.14341\/osteo12697"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Bleizgys A. Vitamin D Dosing: Basic Principles and a Brief Algorithm (2021 Update). Nutrients. 2021;13(12):4415. doi: https:\/\/doi.org\/10.3390\/nu13124415","DOI":"10.3390\/nu13124415"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13687\/10936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:17:32Z","timestamp":1769516252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,1,18]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13687","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,18]]}}}