{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:01:58Z","timestamp":1787907718596,"version":"build-2784847793"},"reference-count":37,"publisher":"Endocrinology Research Centre","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>In recent decades, the Russian government has been committed to improving the country's demographic situation. Therefore, obstetricians and gynecologists pay special attention to women of reproductive age, whose reproductive system disorders can lead to infertility and the inability to conceive. Menstrual cycle disorders (MCDs) are a manifestation of various pathological conditions associated not only with disorders of the female reproductive system but also with general systemic and endocrine diseases. Since the 1980s, the incidence of MCDs has increased more than sevenfold. MCDs are characterized by changes in the cycle frequency, duration, and volume of menstrual blood loss. An obstetrician\/gynecologist who initially consults a woman of reproductive age with MCDs should not only develop an examination plan for the patient, but most importantly, collect a detailed medical history, including a description of her physical condition, sports history, dietary habits, medication intake, including vitamins and dietary supplements, and analyze the relationship between MCDs and epigenetic factors in the woman's life. The incidence of NMC in the presence of an endocrine disease is up to 35% and requires referral of the patient to an endocrinologist to compensate for the endocrinopathy.<\/jats:p>","DOI":"10.14341\/probl13773","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:22:08Z","timestamp":1779304928000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Endocrine genesis of the development of menstrual cycle disorders in reproductive age"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8425-0020","authenticated-orcid":true,"given":"E. N.","family":"Andreeva","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre; Russian University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-0254","authenticated-orcid":true,"given":"E. V.","family":"Sheremetyeva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5458","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Andreeva E.N., Sheremet'eva E.V., Adamyan L.V. Etiologicheskie i patogeneticheskie faktory disfunktsii yaichnikov u zhenshchin reproduktivnogo perioda. \/\/ Problemy reproduktsii. \u2014 2020. \u2014 T.26. \u2014 \u21166. \u2014 S.34 43. doi: https:\/\/doi.org\/10.17116\/repro20202606134","DOI":"10.17116\/repro20202606134"},{"key":"ref2","unstructured":"Kuksina E.A. Analiz zabolevaemosti zhenshchin v Rossii na osnove statisticheskikh dannykh. Magisterskaya dissertatsiya. Napravlenie 01.04.02 Prikladnaya matematika i informatika. Magisterskaya programma Nadezhnost' i bezopasnost' slozhnykh sistem. SPb. 2016."},{"key":"ref3","unstructured":"https:\/\/www.rbc.ru\/life\/news\/694e1d339a7947a835073421"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Begun D.N., Bulycheva E.V., Borshchuk E.L., Choloyan S.B., Gubaidullina L.R. Zabolevaemost' naseleniya vedushchimi nozologicheskimi formami endokrinnoi patologii. \/\/ Menedzher zdravookhraneniya. \u2014 2025. \u2014 \u2116 4. \u2014 S.134\u2013146. doi: https:\/\/doi.org\/10.21045\/1811-0185-2025-4-134-146","DOI":"10.21045\/1811-0185-2025-4-134-146"},{"key":"ref5","unstructured":"https:\/\/scientificrussia.ru\/articles\/kazhdyj-vtoroj-rossiyanin-imeetendokrinnuyu-patologiyu"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lania A, Gianotti L, Gagliardi I, Bondanelli M, Vena W, Ambrosio MR. Functional hypothalamic and druginduced amenorrhea: an overview. Journal of Endocrinological Investigation. 2019;42(9):1001-1010. doi: https:\/\/doi.org\/10.1007\/s40618-019-01013-w","DOI":"10.1007\/s40618-019-01013-w"},{"key":"ref7","unstructured":"Klinicheskie rekomendatsii \u00abAmenoreya i oligomenoreya\u00bb, Moskva, 2025. https:\/\/drive.google.com\/file\/d\/1zWkkVJeuajHTrft3PPD7mStv4wZMr0OT\/view"},{"key":"ref8","unstructured":"Ginekologiya: natsional'noe rukovodstvo. Pod red. Savel'evoi G.M., Sukhikh G.T., Manukhina I.B. \u2014 M.: GEOTAR-Media; 2013"},{"key":"ref9","unstructured":"Rolevoi status i vzaimootnosheniya vracha i patsientki v profilaktike ginekologicheskikh zabolevanii : dissertatsiya ... kandidata meditsinskikh nauk : 14.02.05 \/ Bondarenko Anna Sergeevna; [Mesto zashchity: Volgogr. gos. med. un-t]. \u2014 Volgograd, 2015."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"I.I. Dedov, G.A. Mel'nichenko, L.K. Dzeranova, E.A. Pigarova, S.Yu. Vorotnikova, L.Ya. Rozhinskaya. Federal'nye klinicheskie rekomendatsii po giperprolaktinemii: klinika, diagnostika, differentsial'naya diagnostika i metody lecheniya. \/\/ Problemy endokrinologii. \u2014 2013. \u2014 T.59. \u2014 \u2116 6. \u2014 S. 19\u201426. doi: https:\/\/doi.org\/10.14341\/probl201359619-26","DOI":"10.14341\/probl201359619-26"},{"key":"ref11","unstructured":"Endokrinologiya. Natsional'noe rukovodstvo. Kratkoe izdanie (el.versiya). Pod red. I.I. Dedova, G.A. Mel'nichenko. \u2014 GEOTARMedia, 2025, 832."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Andreeva E.N., Sheremet'eva E.V., Grigoryan O.R. Giperprolaktinemiya u zhenshchin reproduktivnogo vozrasta: chto dolzhen pomnit' vrach. \/\/ Akusherstvo i ginekologiya. \u2014 2021. \u2014 \u21169. \u2014 S. 204-210 doi: https:\/\/dx.doi.org\/10.18565\/aig.2021.9.204-210","DOI":"10.18565\/aig.2021.9.204-210"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Dedov I.I., Mel'nichenko G.A., Dzeranova L.K., Andreeva E.N., Grineva E.N., i dr. Klinicheskie rekomendatsii \u00abGiperprolaktinemiya\u00bb (proekt). \/\/ Ozhirenie i metabolizm. \u2014 2023. \u2014 T.20. \u2014 \u21162. \u2014 S.170-188. doi: https:\/\/doi.org\/10.14341\/omet13002","DOI":"10.14341\/omet13002"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Khripun I.A., Engibaryan E.S., Kuz'menko N.A., Vorob'ev S.V. Endokrinnye prichiny narushenii menstrual'nogo tsikla i printsipy ikh korrektsii \/\/ Endokrinologiya: novosti, mneniya, obuchenie. \u2014 2025. \u2014 T.14, \u2014 \u2116 3. \u2014 C. 65\u201373. doi: https:\/\/doi.org\/10.33029\/2304-9529-2025-14-3-65-73","DOI":"10.33029\/2304-9529-2025-14-3-65-73"},{"key":"ref15","unstructured":"Klinicheskie rekomendatsii \u00abVrozhdennaya disfunktsiya kory nadpochechnikov\u00bb, Moskva, 2024. https:\/\/drive.google.com\/file\/d\/1V0Ux5XBpgrgGLzwUUn9 6oxVlKIfnZiy-\/view"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Esina M.M. Sistema reproduktsii pri gipotireoze. \/\/ Arkhiv akusherstva i ginekologii im. V.F. Snegireva. \u2014 2017. \u2014 T. 4. \u2014 \u21162. \u2014 S. 77\u201483. doi: https:\/\/doi.org\/10.18821\/2313-8726-2017-4-2-77-83","DOI":"10.18821\/2313-8726-2017-4-2-77-83"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kashirova T., Kornejeva I., Perminova S., Fadeev V. Bolezn' Greivsa i reproduktivnaya funktsiya u zhenshchin. \/\/ Klinicheskaya i eksperimental'naya tireoidologiya. \u2014 2007. \u2014 T.3. \u2014 \u21162. \u2014 S.19-25. doi: https:\/\/doi.org\/10.14341\/ket20073219-25","DOI":"10.14341\/ket20073219-25"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Andreeva E.N., Sheremet'eva E.V., Fursenko V.A. Ozhirenie \u2013 ugroza reproduktivnogo potentsiala Rossii. \/\/ Ozhirenie i metabolizm. \u2014 2019. \u2014 T.16. \u2014 \u21163. \u2014 S.20-28. doi: https:\/\/doi.org\/10.14341\/omet10340","DOI":"10.14341\/omet10340"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Filippi-Arriaga F, Agarwal N, Rodrigues-Martins D, Monteiro MP, Huvinen E, et al. EASO Position Statement: Women with Obesity across the Reproductive Life - Fertility, Preconception, Pregnancy, Postpartum, and Breastfeeding. Obes Facts. 2025;21:1-15. doi: https:\/\/doi.org\/10.1159\/000546449","DOI":"10.1159\/000546449"},{"key":"ref20","unstructured":"Klinicheskie rekomendatsii \u00abSindrom polikitsoznykh yachinikov\u00bb, 2025, Moskva. https:\/\/cr.minzdrav.gov.ru\/preview-cr\/910_1"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. 2. Classifi cation and diagnosis of diabetes: standards of medical care in diabetes-2021 \/\/ Diabetes Care. 2021;44(suppl. 1):S15\u2013S33. doi: https:\/\/doi.org\/10.2337\/dc21-S002 Erratum in: Diabetes Care. 2021;44(9). doi: https:\/\/doi.org\/10.2337\/dc21-ad09 PMID: 33298413","DOI":"10.2337\/dc21-ad09"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Greco C, Cacciani M, Corleto R, Simoni M, et al. Alterations in the menstrual cycle as a peculiar sign of type 1 diabetes mellitus: a meta-analytic approach. Can. J. Diabetes. 2024; 48(2):133\u2013140.e2. doi: https:\/\/doi.org\/10.1016\/j","DOI":"10.1016\/j.jcjd.2023.07.009"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Khashchenko E.P., Alekseeva M.N., Pavlovich S.V., Uvarova E.V. Sistematicheskii obzor dannykh ob effektivnosti i bezopasnosti primeneniya didrogesterona pri lechenii narushenii menstrual'nogo tsikla u molodykh patsientok, vklyuchaya period rannego reproduktivnogo vozrasta. \/\/ Akusherstvo i ginekologiya. \u2014 2025. \u2014 \u21168. \u2014 S.57-68 doi: https:\/\/dx.doi.org\/10.18565\/aig.2025.220","DOI":"10.18565\/aig.2025.220"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Trivedi N, Chauhan N, Vaidya V. Effectiveness and safety of dydrogesterone in regularization of menstrual cycle: a postmarketing study. Gynecol. Endocrinol. 2016;32(8):667-71. doi: https:\/\/dx.doi.org\/10.3109\/09513590.2016.1152238","DOI":"10.3109\/09513590.2016.1152238"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Wang L, Guan HY, Xia HX, Chen XY, Zhang W. Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding \u2013 ovulation dysfunction patients. World J. Clin. Cases. 2020;8(15):3259-66. doi: https:\/\/dx.doi.org\/10.12998\/WJCC.V8.I15.3259","DOI":"10.12998\/wjcc.v8.i15.3259"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Ivanishkina-Kudina O.L. Anomal'nye matochnye krovotecheniya rannego reproduktivnogo perioda. Vozmozhnosti terapii preparatom didrogesterona Dyufaston. \/\/ Reproduktivnoe zdorov'e. Vostochnaya Evropa. \u2014 2022. \u2014 T. 12.\u2014 \u21162. \u2014 S. 217-27.","DOI":"10.3390\/agriculture12020217"},{"key":"ref27","unstructured":"Sal'nikova I.A., Uvarova E.V., Khashchenko E.P., Mamedova F.Sh. Osobennosti primeneniya didrogesterona dlya lecheniya matochnogo krovotecheniya v vozraste do 18 let. \/\/ Reproduktivnoe zdorov'e detei i podrostkov. \u2014 2022. \u2014 T. 18.\u2014 \u21164. \u2014 49-65."},{"key":"ref28","unstructured":"Uvarova E.V., Khashchenko E.P., Sal'nikova I.A., Andreeva V.O., Funda i dr. Effektivnost' i bezopasnost' primeneniya didrogesterona u podrostkov mladshe 18 let s narusheniyami menstrual'nogo tsikla. Dannye retrospektivnogo issledovaniya real'noi klinicheskoi praktiki. \/\/ Akusherstvo i ginekologiya. \u2014 2025. \u2014 \u2116 1. \u2014 S 88-96."},{"key":"ref29","unstructured":"Ivanishkina-Kudina O.L., Ikonostasova I.V., Korotkikh O.V. Vozmozhnost' primeneniya didrogesterona v kompleksnom lechenii narushenii menstrual'nogo tsikla i klinicheskogo endometrioza u zhenshchin rannego i molodogo reproduktivnogo vozrasta: obosnovanie i perspektivy konservativnoi terapii. \/\/ Reproduktivnoe zdorov'e Vostochnaya Evropa. \u2014 2021. \u2014 T. 11. \u2014 \u21164. \u2014 S. 487-95."},{"key":"ref30","unstructured":"Sal'nikova I.A., Uvarova E.V. Osobennosti primeneniya didrogesterona s tsel'yu regulyatsii menstrual'nogo tsikla posle ostanovki matochnogo krovotecheniya v pubertatnom periode. \/\/ Reproduktivnoe zdorov'e detei i podrostkov. \u2014 2012. \u2014 \u2116 2. \u2014 S. 42-51."},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Kitawaki J, Koga K, Kanzo T, Momoeda M. An assessment of the efficacy and safety of dydrogesterone in women with ovarian endometrioma: an open-label multicenter clinical study. Reprod. Med. Biol. 2021;20(3): 345-351. doi: https:\/\/dx.doi.org\/10.1002\/rmb2.12391","DOI":"10.1002\/rmb2.12391"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Schindler AE. Progestational effects of dydrogesterone in vitro, in vivo and on the human endometrium. Maturitas. 2009;65(S.1):S3-11. doi: https:\/\/doi.org\/10.1016\/j.maturitas.2009.10.011","DOI":"10.1016\/j.maturitas.2009.10.011"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Yasuda K, Sumi G, Murata H, Kida N, Kido T, Okada H. The steroid hormone dydrogesterone inhibits myometrial contraction independently of the progesterone \/ progesterone receptor pathway. Life Sci. 2018; 207: 508-15. doi: https:\/\/doi.org\/10.1016\/j.lfs.2018.07.004","DOI":"10.1016\/j.lfs.2018.07.004"},{"key":"ref34","unstructured":"Obshchaya kharakteristika lekarstvennogo preparata \u00abDidromens\u00bb LP-\u2116(010053)-(RG-RU)-060525 Available via the link: https:\/\/pharma.eaeunion.org\/pharma\/registers\/26\/ru\/register\/registered-medicinalproducts\/68d12d030dcf88d7dd87118"},{"key":"ref35","unstructured":"Rezyume klinicheskikh issledovanii, versiya 1.0 ot 19.06.2024 (informatsiya mozhet byt' predostavlena po zaprosu na adres info@binnopharmgroup.ru)"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Mesen TB1, Young SL. Progesterone and the luteal phase: a requisite to reproduction. Obstet Gynecol Clin North Am. 2015;42(1):135-51","DOI":"10.1016\/j.ogc.2014.10.003"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Andreeva E.N., Sheremet'eva E.V., Grigoryan O.R. 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