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Despite the evidence of interactions between ageing and accumulation of endocrine disruptions, the last 150 years of variegated searches for potential endocrine \u201celixir of lon gevity\u201d brought contradictive, mutually exclusive and even discouraging results. Fortunately, the discovery of referent lab oratory intervals of hormonal blood levels among elderly people improved the overall situation. Traditional treatment of endocrine hormonal deficiency with replacement therapy does not lead to rejuvenation but to potential damage. That\u2019s why it is more accepted to interpret hormonal changes among elderly people not only as aging but specific adaptation for \u201csuccessful ageing\u201d. The present review contains modern datas about endocrine ageing of thyroid gland, adrenal glands (hy percorticism, adrenopause), pituitary gland (somatopause, hypoprolactinemia), male (andropause) and female (menopause, hyperandrogenism) hypogonadism.<\/jats:p>","DOI":"10.14341\/probl13774","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:36:30Z","timestamp":1789054590000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["The unbearable versatility of endocrine aging"],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-3186","authenticated-orcid":true,"given":"R. K.","family":"Mikheev","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-7420","authenticated-orcid":true,"given":"O. 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