{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:08:26Z","timestamp":1789056506698,"version":"build-2803163510"},"reference-count":27,"publisher":"Endocrinology Research Centre","issue":"4","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>On March 25, 2026, a meeting of the Expert Council entitled \"Hypoparathyroidism in the Era of Complex Challenges and Breakthrough Technologies\" was held in Moscow at the Endocrinology Research Centre. The meeting focused on the epidemiology of chronic hypoparathyroidism (hypoPT) in Russia, the specifics of patient management with this pathology in other countries, and the similarities and differences between international and Russian clinical guidelines.<\/jats:p>\n                  <jats:p>The meeting discussed advances in improving diagnostics and personalized treatment for patients with hypoPT in Russia, as well as the need to implement best practices in practical healthcare as part of the 2027 clinical guidelines revision.<\/jats:p>\n                  <jats:p>The importance of including chronic hypoPT in the official list of rare (orphan) diseases was highlighted, as was the need to continue studying the characteristics of the disease and its complications, diagnosis, monitoring, and prevention of hypoPT, including in the long term. The meeting also highlighted the relevance of an interdisciplinary professional alliance to achieve optimal treatment outcomes and improve the quality of life of patients with chronic hypoPT. The experts highlighted the need to implement innovative, effective treatment methods, including hormone replacement therapy for hypoPT. The Council discussed the efficacy and safety of the new therapeutic technology, TransCon parathyroid hormone. Invited expert Dilek Gogas Yavuz, MD, Professor at the Marmara University School of Medicine, Department of Endocrinology and Metabolism, Department of Internal Medicine (Istanbul, Turkey), shared her experience with the drug and the results of international clinical trials. This resolution is a summary of the issues discussed in the Council members\u2019 presentations and during the professional discussions.<\/jats:p>","DOI":"10.14341\/probl13805","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:36:30Z","timestamp":1789054590000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Resolution of the Joint Meeting of the Expert Council \"Hypoparathyroidism in the Era of Complex Problems and Breakthrough Technologies\""],"prefix":"10.14341","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-9742","authenticated-orcid":true,"given":"N. G.","family":"Mokrysheva","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-2217","authenticated-orcid":true,"given":"T. P.","family":"Bardymova","sequence":"additional","affiliation":[{"name":"Irkutsk State Medical Academy of Postgraduate Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-5846","authenticated-orcid":true,"given":"E. E.","family":"Bibik","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-062X","authenticated-orcid":true,"given":"A. K.","family":"Eremkina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-0123","authenticated-orcid":true,"given":"T. L.","family":"Karonova","sequence":"additional","affiliation":[{"name":"V.A. Almazov National Medical Research Center of Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-2591","authenticated-orcid":true,"given":"E. V.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7876-5105","authenticated-orcid":true,"given":"I. V.","family":"Kryukova","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u00abMONIKI\u00bb)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-5725","authenticated-orcid":true,"given":"I. P.","family":"Malaya","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-4627","authenticated-orcid":true,"given":"V. 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(In Russ.) doi: https:\/\/doi.org\/10.14341\/ket12802","DOI":"10.14341\/ket12802"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Elfimova AR, Krupinova JA, Bibik EE, et al. The Russian Registry of Chronic Hypoparathyroidism. Front. Endocrinol. 13:800119. doi: https:\/\/doi.org\/10.3389\/fendo.2022.800119","DOI":"10.3389\/fendo.2022.800119"},{"key":"ref4","unstructured":"Hronicheskij gipoparatireoz: prediktory razvitiya oslozhnenij zabolevaniya i personalizaciya vedeniya pacientov. Kovaleva EV. \u2014 Diss. na soiskanie uch. st. k.m.n., 2022 g. (In Russ.)"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Ajnetdinova R, Miliutina P, Mokrysheva NG. The Russian registry of chronic hypoparathyroidism and clinical decision support system integration. Problems of Endocrinology. 2021;67(4):8-12. (In Russ.) doi: https:\/\/doi.org\/10.14341\/probl12796","DOI":"10.14341\/probl12796"},{"key":"ref6","unstructured":"Sposob individualizirovannogo podbora doz lekarstvennyh preparatov dlya lecheniya pacientov s hronicheskim gipoparatireozom. Mokrysheva Natal\u2019ya Georgievna, Eremkina Anna Konstantinovna, Kovaleva Elena Vladimirovna, Elfimova Alina Rinatovna, Pershina-Milyutina Anastasiya Pavlovna. Patent na izobretenie \u21162861630, 6 maya 2026 g. (In Russ.)"},{"key":"ref7","unstructured":"\u041f\u0435\u0440\u0435\u0447\u0435\u043d\u044c \u0440\u0435\u0434\u043a\u0438\u0445 (\u043e\u0440\u0444\u0430\u043d\u043d\u044b\u0445) \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439, \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432 \u0420\u043e\u0441\u0441\u0438\u0438, \u043e\u0442 14 \u0430\u043f\u0440\u0435\u043b\u044f 2026 \u0433\u043e\u0434\u0430, https:\/\/minzdrav.gov.ru\/documents\/9863-perechen-redkih-orfannyh-zabolevaniy."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Bollerslev J, Rejnmark L, Marcocci C, Shoback DM, Sitges-Serra A, et al; European Society of Endocrinology. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Eur J Endocrinol. 2015;173(2):G1-20. doi: https:\/\/doi.org\/10.1530\/EJE-15-0628","DOI":"10.1530\/EJE-15-0628"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Bollerslev J, Buch O, Cardoso LM, Gittoes N, Houillier P, et al. Revised European Society of Endocrinology Clinical Practice Guideline: Treatment of Chronic Hypoparathyroidism in Adults. Eur J Endocrinol. 202;193(5):G49-G78. doi: https:\/\/doi.org\/10.1093\/ejendo\/lvaf222","DOI":"10.1093\/ejendo\/lvaf222"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Misiorowski W, Kos-Kud\u0142a B, Hubalewska-Dydejczyk A, Rucha\u0142a M, Zgliczy\u0144ski W, et al. Treatment of hypoparathyroidism (HypoPT): Position Statement of the Expert Group for Polish Society of Endocrinology - update 2026. Endokrynol Pol. 2026;77(1):1-4. doi: https:\/\/doi.org\/10.5603\/ep.110591","DOI":"10.5603\/ep.110591"},{"key":"ref11","unstructured":"Guidelines on the therapeutic management of post-surgical hypoparathyroidism in adults. Association of Endocrinologists (AME), Italian Society of Endocrinology (SIE), Italian Society of Orthopedics and Traumatology (SIOT), Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS), Italian Society of Endocrine Surgery (SIUEC), Istituto Superiore di Sanit\u00e0, 2025"},{"key":"ref12","unstructured":"Guidelines for the Diagnosis and Treatment of Osteoporosis and Metabolic Bone Diseases. Turkish Society of Endocrinology and Metabolism, 2025"},{"key":"ref13","unstructured":"Klinicheskie rekomendacii po gipoparatireozu u vzroslyh. Ministerstvo zdravoohraneniya Rossijskoj Federacii, 2025 g."},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Mokrysheva NG. Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series. Obesity and metabolism. 2021;18(2):175-179. (In Russ.) doi: https:\/\/doi.org\/10.14341\/omet12729","DOI":"10.14341\/omet12729"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Kovaleva EV, Eremkina AK, Mokrysheva NG. Chronic hypoparathyroidism: clinical manifestations, complications and impact on the quality of life. FOCUS. Endocrinology. 2023;4(1):78-83. (In Russ.) doi: https:\/\/doi.org\/10.15829\/2713-0177-2023-27","DOI":"10.15829\/2713-0177-2023-27"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Arlt W, Fremerey C, Callies F, et al. Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol. Published online February 1, 2002:215-222. doi: https:\/\/doi.org\/10.1530\/eje.0.1460215","DOI":"10.1530\/eje.0.1460215"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Sikjaer T, Moser E, Rolighed L, et al. Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism. Journal of Bone and Mineral Research. 2016;31(7):1440-1448. doi: 10.1002\/jbmr.2812","DOI":"10.1002\/jbmr.2812"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Underbjerg L, Sikjaer T, Rejnmark L. Health\u2010related quality of life in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism. Clin Endocrinol (Oxf ). 2018;88(6):838-847. doi: https:\/\/doi.org\/10.1111\/cen.13593","DOI":"10.1111\/cen.13593"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Siggelkow H, Clarke BL, Germak J, et al. Burden of illness in not adequately controlled chronic hypoparathyroidism: Findings from a 13\u2010country patient and caregiver survey. Clin Endocrinol (Oxf ). 2020;92(2):159-168. doi: https:\/\/doi.org\/10.1111\/cen.14128","DOI":"10.1111\/cen.14128"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Winer KK, et al. Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium. J. Clin. Endocrinol. Metab. United States. 2003;88(9):4214\u20134220. doi: https:\/\/doi.org\/10.1210\/jc.2002-021736","DOI":"10.1210\/jc.2002-021736"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Marcucci G, et al. Chronic hypoparathyroidism and treatment with teriparatide. Endocrine. 2021;72(1):249-259. doi: https:\/\/doi.org\/10.1007\/s12020-020-02577-x","DOI":"10.1007\/s12020-020-02577-x"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Winer KK, et al. Effects of once versus twice-daily parathyroid hormone 1-34 therapy in children with hypoparathyroidism. J. Clin. Endocrinol. Metab. 2008;93(9): 3389\u20133395. doi: https:\/\/doi.org\/10.1210\/jc.2007-2552","DOI":"10.1210\/jc.2007-2552"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Winer KK, et al. Long-Term Parathyroid Hormone 1-34 Replacement Therapy in Children with Hypoparathyroidism. J. Pediatr. Elsevier Inc. 2018;203(391-399):e1. doi: https:\/\/doi.org\/10.1016\/j.jpeds.2018.08.010","DOI":"10.1016\/j.jpeds.2018.08.010"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Karpf DB, Pihl S, Mourya S, Mortensen E, Kovoor E, Markova D, Leff JA. A Randomized Double-Blind Placebo-Controlled First-In-Human Phase 1 Trial of TransCon PTH in Healthy Adults. J Bone Miner Res. 2020;35(8):1430-1440. doi: 10 doi: https:\/\/doi.org\/.1002\/jbmr.4016","DOI":"10.1002\/jbmr.4016"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Khan AA, Rejnmark L, Rubin M, Schwarz P, Vokes T, Clarke B, et al. PaTH Forward: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial of TransCon PTH in Adult Hypoparathyroidism. J Clin Endocrinol Metab. 2022;107(1):e372-e385. doi: https:\/\/doi.org\/10.1210\/clinem\/dgab577","DOI":"10.1210\/clinem\/dgab577"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, et al. Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial. J Bone Miner Res. 2023;38(1):14-25. doi: https:\/\/doi.org\/10.1002\/jbmr.4726","DOI":"10.1002\/jbmr.4726"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Bart L Clarke, Aliya A Khan, Mishaela R Rubin, Peter Schwarz, Tamara Vokes, et al., Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial. The Journal of Clinical Endocrinology & Metabolism. 2025;110(4):951\u2013960. doi: https:\/\/doi.org\/10.1210\/clinem\/dgae693","DOI":"10.1210\/clinem\/dgaf048"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/13805\/11032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:36:55Z","timestamp":1789054615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/13805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,9,8]]}},"URL":"https:\/\/doi.org\/10.14341\/probl13805","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,8]]}}}