{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:40:45Z","timestamp":1769913645333,"version":"3.49.0"},"reference-count":0,"publisher":"Endocrinology Research Centre","issue":"1","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["probl-endojournals.ru"],"crossmark-restriction":false},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Effective regeneration of damaged soft orbital tissues in Graves ophthalmopathy (GO) requires coordinated remodeling of the extracellular matrix. Matrix metalloproteinases (MMPs) play an important role in the synthesis and degradation homeostasis of extracellular matrix components in various physiological and pathological conditions. Their proteolytic activity is inhibited by tissue inhibitors of metalloproteinases (TIMP). The biochemical processes taking place in extraocular muscles and retrobulbar tissue fibrogenesis in GO are not fully understood.\r\nAims  to assess some biochemical mechanisms of extraocular muscles and retrobulbar tissue fibrogenesis in GO patients.\r\nMaterial and methods. The study included 65 people (130 eyes) at the age of 43 (3550) years. Three groups of subjects were formed: 32 patients with a moderate GO severity (clinical group), 18 patients with autoimmune thyroid pathology without GO (comparison group), and 15 healthy persons (control). The diagnosis was based on clinical, laboratory, and instrumental data. A comprehensive ophthalmologic examination and blood sampling for determination of MMP-1, -13, TIMP-1, sulfated glycosaminoglycans (sGAG) and antibodies to thyroid-stimulating hormone receptor (TSHRAbs) were conducted. The data were statistically processed using the program Statistica 10.0.\r\nResults. An elevated level of MMP-13, observed in all GO patients (p0.05). For the active phase of GOP, the comparison with the control group showed a 3.5-fold increase in MMP-13 (p0.001) and 1.17-fold rise in TIMP-1 (p0.05). Pulse glucocorticoid therapy reduced MMP-13 by 48.6% (p0.001), TIMP-1 by 2.7% (p0.001), and TSHRAbs  by 93% (p0.001) compared with active GO, but these indicators were higher than the reference limits of control (p0.05). In inactive GO, despite increased MMP-13, TIMP-1 decreased to the reference values (p=0.533). There were no significant differences in MMP-1 in groups of subjects (p=0.865).\r\nConclusions. We have found imbalance between MMP-13 and TIMP-1 production in different activity phases of GO. Active GO is characterized by an increase in serum MMP-13 and TIMP-1. Dysregulation of intercellular matrix remodeling, possibly, underlies the development of extraocular muscles and retrobulbar tissue fibrosis in GO.<\/jats:p>","DOI":"10.14341\/probl9750","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T07:18:50Z","timestamp":1546586330000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":3,"title":["Matrix metalloproteinases-1, -13 and their tissue inhibitor-1 in endocrine ophthalmopathy"],"prefix":"10.14341","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-8888","authenticated-orcid":false,"given":"Elizaveta S.","family":"Taskina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-5465","authenticated-orcid":false,"given":"Svetlana V.","family":"Kharintseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2019,5,14]]},"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/viewFile\/9750\/7620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/viewFile\/9750\/7833","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/viewFile\/9750\/7833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T20:17:53Z","timestamp":1571948273000},"score":1,"resource":{"primary":{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/view\/9750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,14]]}},"URL":"https:\/\/doi.org\/10.14341\/probl9750","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"value":"2308-1430","type":"electronic"},{"value":"0375-9660","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}