{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:28:08Z","timestamp":1773343688992,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2011-0030074"],"award-info":[{"award-number":["2011-0030074"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2011-0023431"],"award-info":[{"award-number":["2011-0023431"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2012-M3A9B6055466"],"award-info":[{"award-number":["2012-M3A9B6055466"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.14348\/molcells.2014.0158","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T02:49:27Z","timestamp":1406774967000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Systemic Approaches Identify a Garlic-Derived Chemical, Z-ajoene, as a Glioblastoma Multiforme Cancer Stem Cell-Specific Targeting Agent"],"prefix":"10.1016","volume":"37","author":[{"given":"Yuchae","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Ha","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.14348\/molcells.2014.0158_bib1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1158\/1535-7163.MCT-11-0205","article-title":"Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRalpha\/beta","volume":"10","author":"Bielen","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.14348\/molcells.2014.0158_bib2","doi-asserted-by":"crossref","first-page":"8295","DOI":"10.1021\/ja00338a049","article-title":"The chemistry of alkyl thiosulfate esters. 8. (E,Z)-Ajoene: a potent antithrombotic agent from garlic","volume":"106","author":"Block","year":"1984","journal-title":"J Am Chem Soc"},{"key":"10.14348\/molcells.2014.0158_bib3","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"10.14348\/molcells.2014.0158_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.14348\/molcells.2014.0158_bib5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1124\/mol.53.3.402","article-title":"Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB","volume":"53","author":"Dirsch","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.14348\/molcells.2014.0158_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cell.2011.06.006","article-title":"Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2","volume":"146","author":"Eyler","year":"2011","journal-title":"Cell"},{"key":"10.14348\/molcells.2014.0158_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/abio.1995.1318","article-title":"A microplate assay for quantitation of anchorage-independent growth of transformed cells","volume":"228","author":"Fukazawa","year":"1995","journal-title":"Anal Biochem"},{"key":"10.14348\/molcells.2014.0158_bib8","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2174\/092986709788186147","article-title":"Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance","volume":"16","author":"Gangemi","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.14348\/molcells.2014.0158_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1634\/stemcells.2004-0102","article-title":"Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency","volume":"23","author":"Gerrard","year":"2005","journal-title":"Stem Cells"},{"key":"10.14348\/molcells.2014.0158_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","article-title":"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome","volume":"1","author":"Ginestier","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.14348\/molcells.2014.0158_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2011.04.006","article-title":"Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells","volume":"254","author":"Hyun","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.14348\/molcells.2014.0158_bib12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejmech.2012.01.058","article-title":"Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells","volume":"50","author":"Kaschula","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.14348\/molcells.2014.0158_bib13","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/jid.2013.510","article-title":"FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation","volume":"134","author":"Kim","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.14348\/molcells.2014.0158_bib14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1089\/jmf.2012.2275","article-title":"Anti-inflammatory activity of sulfur-containing compounds from garlic","volume":"15","author":"Lee da","year":"2012","journal-title":"J Med Food"},{"key":"10.14348\/molcells.2014.0158_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/carcin\/23.4.573","article-title":"Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties","volume":"23","author":"Li","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.14348\/molcells.2014.0158_bib16","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1073\/pnas.1110431108","article-title":"Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells","volume":"108","author":"Lu","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.14348\/molcells.2014.0158_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/1477-3163.91413","article-title":"Shared signaling pathways in normal and breast cancer stem cells","volume":"10","author":"Malhotra","year":"2011","journal-title":"J Carcinog"},{"key":"10.14348\/molcells.2014.0158_bib18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.14348\/molcells.2014.0158_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/srep00516","article-title":"Targeting JNK for therapeutic depletion of stem-like glioblastoma cells","volume":"2","author":"Matsuda","year":"2012","journal-title":"Sci Rep"},{"key":"10.14348\/molcells.2014.0158_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature08734","article-title":"TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia","volume":"463","author":"Naka","year":"2010","journal-title":"Nature"},{"key":"10.14348\/molcells.2014.0158_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccr.2009.02.011","article-title":"TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma","volume":"15","author":"Penuelas","year":"2009","journal-title":"Cancer Cell"},{"key":"10.14348\/molcells.2014.0158_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.stem.2009.09.014","article-title":"FoxO3 regulates neural stem cell homeostasis","volume":"5","author":"Renault","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.14348\/molcells.2014.0158_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"10.14348\/molcells.2014.0158_bib24","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1038\/onc.2009.252","article-title":"Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha","volume":"28","author":"Soeda","year":"2009","journal-title":"Oncogene"},{"key":"10.14348\/molcells.2014.0158_bib25","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/stem.521","article-title":"Crosstalk between the PI3K\/mTOR and MEK\/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells","volume":"28","author":"Sunayama","year":"2010","journal-title":"Stem Cells"},{"key":"10.14348\/molcells.2014.0158_bib26","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/stem.696","article-title":"FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity","volume":"29","author":"Sunayama","year":"2011","journal-title":"Stem Cells"},{"key":"10.14348\/molcells.2014.0158_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.canlet.2005.08.022","article-title":"Ajoene inhibits both primary tumor growth and metastasis of B16\/BL6 melanoma cells in C57BL\/6 mice","volume":"239","author":"Taylor","year":"2006","journal-title":"Cancer Lett"},{"key":"10.14348\/molcells.2014.0158_bib28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/nar\/gkg034","article-title":"STRING: a database of predicted functional associations between proteins","volume":"31","author":"von Mering","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.14348\/molcells.2014.0158_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ncomms1074","article-title":"Non-muscle myosin II regulates survival threshold of pluripotent stem cells","volume":"1","author":"Walker","year":"2010","journal-title":"Nat Commun"},{"key":"10.14348\/molcells.2014.0158_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature11895","article-title":"FOXO3A directs a protective autophagy program in haematopoietic stem cells","volume":"494","author":"Warr","year":"2013","journal-title":"Nature"},{"key":"10.14348\/molcells.2014.0158_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2008.323","article-title":"Roles of TGF-beta family signaling in stem cell renewal and differentiation","volume":"19","author":"Watabe","year":"2009","journal-title":"Cell Res"},{"key":"10.14348\/molcells.2014.0158_bib32","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1038\/onc.2011.634","article-title":"c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells","volume":"31","author":"Yoon","year":"2012","journal-title":"Oncogene"},{"key":"10.14348\/molcells.2014.0158_bib33","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1158\/0008-5472.CAN-08-0364","article-title":"Identification and characterization of ovarian cancer-initiating cells from primary human tumors","volume":"68","author":"Zhang","year":"2008","journal-title":"Cancer Res"},{"key":"10.14348\/molcells.2014.0158_bib34","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2174\/138945011796150325","article-title":"Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned?","volume":"12","author":"Zhang","year":"2011","journal-title":"Curr Drug Targets"}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823053438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823053438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ocean.kisti.re.kr\/downfile\/crosscheck\/ksmcb\/JAKO201425560113710.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T17:49:52Z","timestamp":1760896192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847823053438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1016847823053438"],"URL":"https:\/\/doi.org\/10.14348\/molcells.2014.0158","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Approaches Identify a Garlic-Derived Chemical, Z-ajoene, as a Glioblastoma Multiforme Cancer Stem Cell-Specific Targeting Agent","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14348\/molcells.2014.0158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 THE AUTHORS. Published by Elsevier Inc on behalf of the Korean Society for Molecular and Cellular Biology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}