{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:27:51Z","timestamp":1790486871813,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.14348\/molcells.2015.2120","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T03:47:50Z","timestamp":1418701670000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Itch E3 Ubiquitin Ligase Positively Regulates TGF-\u03b2 Signaling to EMT via Smad7 Ubiquitination"],"prefix":"10.1016","volume":"38","author":[{"given":"Su-hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ho","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyang","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hoon","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14348\/molcells.2015.2120_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2004.07.021","article-title":"Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation","volume":"15","author":"Bai","year":"2004","journal-title":"Mol. Cell"},{"key":"10.14348\/molcells.2015.2120_bib2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ncb434","article-title":"Differentiation plasticity regulated by TGF-beta family proteins in development and disease","volume":"9","author":"Derynck","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.14348\/molcells.2015.2120_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni763","article-title":"Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation","volume":"3","author":"Fang","year":"2002","journal-title":"Nat. Immunol"},{"key":"10.14348\/molcells.2015.2120_bib4","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1073\/pnas.1101273108","article-title":"Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]","volume":"108","author":"Ho","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.14348\/molcells.2015.2120_bib5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","article-title":"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation","volume":"6","author":"Kavsak","year":"2000","journal-title":"Mol. Cell"},{"key":"10.14348\/molcells.2015.2120_bib6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s10059-013-0233-4","article-title":"SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion","volume":"36","author":"Kwon","year":"2013","journal-title":"Mol. Cells"},{"key":"10.14348\/molcells.2015.2120_bib7","doi-asserted-by":"crossref","first-page":"27645","DOI":"10.1074\/jbc.M500188200","article-title":"AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism","volume":"280","author":"Lallemand","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.14348\/molcells.2015.2120_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ajhg.2010.01.028","article-title":"Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease","volume":"86","author":"Lohr","year":"2010","journal-title":"Am. J. Hum. Genet"},{"key":"10.14348\/molcells.2015.2120_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ng0298-143","article-title":"The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18","volume":"18","author":"Perry","year":"1998","journal-title":"H mice. Nat. Genet"},{"key":"10.14348\/molcells.2015.2120_bib10","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1073\/pnas.0603449103","article-title":"The E3 ubiquitin ligase Itch controls the protein stability of p63","volume":"103","author":"Rossi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.14348\/molcells.2015.2120_bib11","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1158\/0008-5472.CAN-10-3516","article-title":"Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity","volume":"71","author":"Salah","year":"2011","journal-title":"Cancer Res"},{"key":"10.14348\/molcells.2015.2120_bib12","doi-asserted-by":"crossref","first-page":"12148","DOI":"10.1074\/jbc.273.20.12148","article-title":"Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7","volume":"273","author":"Schwarz","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.14348\/molcells.2015.2120_bib13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.14348\/molcells.2015.2120_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00281-009-0192-1","article-title":"Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch","volume":"32","author":"Su","year":"2010","journal-title":"Semin. Immunopathol"},{"key":"10.14348\/molcells.2015.2120_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ni1564","article-title":"The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1","volume":"9","author":"Venuprasad","year":"2008","journal-title":"Nat. Immunol"},{"key":"10.14348\/molcells.2015.2120_bib16","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/MCB.00251-12","article-title":"The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein","volume":"32","author":"Wei","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"10.14348\/molcells.2015.2120_bib17","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCRESAHA.107.156877","article-title":"Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells","volume":"102","author":"Woo","year":"2008","journal-title":"Circ. Res"},{"key":"10.14348\/molcells.2015.2120_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/mcne.1998.0677","article-title":"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins","volume":"11","author":"Wood","year":"1998","journal-title":"Mol. Cell. Neurosci"},{"key":"10.14348\/molcells.2015.2120_bib19","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1128\/MCB.01636-06","article-title":"Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell. Biol"}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823053931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823053931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ocean.kisti.re.kr\/downfile\/crosscheck\/ksmcb\/JAKO201506234293937.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T17:49:22Z","timestamp":1760896162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847823053931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1016847823053931"],"URL":"https:\/\/doi.org\/10.14348\/molcells.2015.2120","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Itch E3 Ubiquitin Ligase Positively Regulates TGF-\u03b2 Signaling to EMT via Smad7 Ubiquitination","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14348\/molcells.2015.2120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 THE AUTHORS. Published by Elsevier Inc on behalf of the Korean Society for Molecular and Cellular Biology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}