{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:37:29Z","timestamp":1772771849249,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.14348\/molcells.2021.0027","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:16:26Z","timestamp":1617322586000},"page":"168-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-6163","authenticated-orcid":false,"given":"Dai","family":"Le","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-2282","authenticated-orcid":false,"given":"Soyeon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-7047","authenticated-orcid":false,"given":"Kwang Wook","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-5750","authenticated-orcid":false,"given":"Joon Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-8292","authenticated-orcid":false,"given":"Youjoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-1593","authenticated-orcid":false,"given":"Taejeong","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-2238","authenticated-orcid":false,"given":"Kyeong Hwan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-0226","authenticated-orcid":false,"given":"Kay-Uwe","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0767-1918","authenticated-orcid":false,"given":"Jin Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.14348\/molcells.2021.0027_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF02359619","article-title":"Epidermal growth factor receptors","volume":"34","author":"Adamson","year":"1981","journal-title":"Mol. Cell. Biochem."},{"key":"10.14348\/molcells.2021.0027_bib2","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1083\/jcb.109.5.2129","article-title":"Membrane domains of intestinal epithelial cells: distribution of Na+,K+-ATPase and the membrane skeleton in adult rat intestine during fetal development and after epithelial isolation","volume":"109","author":"Amerongen","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ceb.2011.04.008","article-title":"MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between","volume":"23","author":"Babst","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib4","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1242\/jcs.209197","article-title":"The EGFR odyssey - from activation to destruction in space and time","volume":"130","author":"Bakker","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.14348\/molcells.2021.0027_bib5","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1083\/jcb.147.7.1533","article-title":"Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium","volume":"147","author":"Bonilha","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib6","first-page":"2963","article-title":"Expression of E-cadherin by human retinal pigment epithelium: delayed expression in vitro","volume":"40","author":"Burke","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib7","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1167\/iovs.06-0104","article-title":"Fate of E-cadherin in early RPE cultures: transient accumulation of truncated peptides at nonjunctional sites","volume":"47","author":"Burke","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib8","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1038\/cddis.2013.303","article-title":"Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability","volume":"4","author":"Cachafeiro","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.14348\/molcells.2021.0027_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2012.08.011","article-title":"Governance of endocytic trafficking and signaling by reversible ubiquitylation","volume":"23","author":"Clague","year":"2012","journal-title":"Dev. Cell"},{"key":"10.14348\/molcells.2021.0027_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/BST0370173","article-title":"Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies","volume":"37","author":"Eden","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.14348\/molcells.2021.0027_bib11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/bbrc.1999.0400","article-title":"Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1","volume":"256","author":"Fang","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14348\/molcells.2021.0027_bib12","doi-asserted-by":"crossref","first-page":"12932","DOI":"10.1073\/pnas.94.24.12932","article-title":"Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization","volume":"94","author":"Finnemann","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.14348\/molcells.2021.0027_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2009.07.002","article-title":"Spatial and temporal regulation of Wnt\/\u03b2-catenin signaling is essential for development of the retinal pigment epithelium","volume":"334","author":"Fujimura","year":"2009","journal-title":"Dev. Biol."},{"key":"10.14348\/molcells.2021.0027_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1350-9462(96)00037-7","article-title":"Retinal pigment epithelial transport mechanisms and their contributions to the electroretinogram","volume":"16","author":"Gallemore","year":"1997","journal-title":"Prog. Retin. Eye Res."},{"key":"10.14348\/molcells.2021.0027_bib15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrm2755","article-title":"Pathways and mechanisms of endocytic recycling","volume":"10","author":"Grant","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrm1360","article-title":"The biogenesis of multivesicular endosomes","volume":"5","author":"Gruenberg","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.112.5.863","article-title":"Apical polarity of Na,K-ATPase in retinal pigment epithelium is linked to a reversal of the ankyrin-fodrin submembrane cytoskeleton","volume":"112","author":"Gundersen","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.celrep.2017.03.040","article-title":"The retinal pigment epithelium is a Notch signaling niche in the mouse retina","volume":"19","author":"Ha","year":"2017","journal-title":"Cell Rep."},{"key":"10.14348\/molcells.2021.0027_bib19","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1242\/dev.02356","article-title":"vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis","volume":"133","author":"Herz","year":"2006","journal-title":"Development"},{"key":"10.14348\/molcells.2021.0027_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/10409238.2010.502516","article-title":"The ESCRT complexes","volume":"45","author":"Hurley","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.14348\/molcells.2021.0027_bib21","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1167\/iovs.10-6347","article-title":"Generation of Cre transgenic mice with postnatal RPE-specific ocular expression","volume":"52","author":"Iacovelli","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib22","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.0602131103","article-title":"Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration","volume":"103","author":"Imamura","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.14348\/molcells.2021.0027_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molmed.2009.03.005","article-title":"The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration","volume":"15","author":"Kang","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.14348\/molcells.2021.0027_bib24","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1101\/gad.1700108","article-title":"Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium","volume":"22","author":"Kim","year":"2008","journal-title":"Genes Dev."},{"key":"10.14348\/molcells.2021.0027_bib25","doi-asserted-by":"crossref","first-page":"e21303","DOI":"10.7554\/eLife.21303","article-title":"The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity","volume":"6","author":"Kim","year":"2017","journal-title":"Elife"},{"key":"10.14348\/molcells.2021.0027_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0167-4889(98)00057-3","article-title":"Protein transport from the secretory to the endocytic pathway in mammalian cells","volume":"1404","author":"Le Borgne","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14348\/molcells.2021.0027_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.exer.2014.04.021","article-title":"Plasma membrane protein polarity and trafficking in RPE cells: past, present and future","volume":"126","author":"Lehmann","year":"2014","journal-title":"Exp. Eye Res."},{"issue":"Pt 1","key":"10.14348\/molcells.2021.0027_bib28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1042\/BST0370178","article-title":"ESCRT proteins and the regulation of endocytic delivery to lysosomes","volume":"37","author":"Luzio","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.14348\/molcells.2021.0027_bib29","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1034\/j.1600-0854.2001.21202.x","article-title":"The polarity of the retinal pigment epithelium","volume":"2","author":"Marmorstein","year":"2001","journal-title":"Traffic"},{"key":"10.14348\/molcells.2021.0027_bib30","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/bies.20064","article-title":"Eye development: a view from the retina pigmented epithelium","volume":"26","author":"Martinez-Morales","year":"2004","journal-title":"Bioessays"},{"key":"10.14348\/molcells.2021.0027_bib31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nrm2525","article-title":"Coordinated protein sorting, targeting and distribution in polarized cells","volume":"9","author":"Mellman","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.devcel.2005.09.018","article-title":"Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth","volume":"9","author":"Moberg","year":"2005","journal-title":"Dev. Cell"},{"key":"10.14348\/molcells.2021.0027_bib33","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/dvg.22044","article-title":"Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium","volume":"50","author":"Mori","year":"2012","journal-title":"Genesis"},{"key":"10.14348\/molcells.2021.0027_bib34","first-page":"1384","article-title":"Site-specific somatic mutagenesis in the retinal pigment epithelium","volume":"43","author":"Mori","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib35","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1742-4658.2012.08534.x","article-title":"Differential requirements of mammalian ESCRTs in multivesicular body formation, virus budding and cell division","volume":"279","author":"Morita","year":"2012","journal-title":"FEBS J."},{"key":"10.14348\/molcells.2021.0027_bib36","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3775","article-title":"Organization and execution of the epithelial polarity programme","volume":"15","author":"Rodriguez-Boulan","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ydbio.2004.03.039","article-title":"Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter","volume":"271","author":"Rowan","year":"2004","journal-title":"Dev. Biol."},{"key":"10.14348\/molcells.2021.0027_bib39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tibs.2007.09.010","article-title":"ESCRTing proteins in the endocytic pathway","volume":"32","author":"Saksena","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.14348\/molcells.2021.0027_bib40","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1016\/j.cub.2012.01.028","article-title":"The ESCRT machinery","volume":"22","author":"Schmidt","year":"2012","journal-title":"Curr. Biol."},{"key":"10.14348\/molcells.2021.0027_bib41","first-page":"96","article-title":"Na+,K+-ATPase activity in cultured bovine retinal pigment epithelium","volume":"40","author":"Shimura","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.14348\/molcells.2021.0027_bib42","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tcb.2010.04.003","article-title":"Polarity and endocytosis: reciprocal regulation","volume":"20","author":"Shivas","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib43","doi-asserted-by":"crossref","first-page":"190724","DOI":"10.1155\/2010\/190724","article-title":"The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier - implications for the pathogenesis of diabetic retinopathy","volume":"2010","author":"Sim\u00f3","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.14348\/molcells.2021.0027_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.14348\/molcells.2021.0027_bib45","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.14348\/molcells.2021.0027_bib46","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1083\/jcb.104.5.1239","article-title":"Localization of Na+,K+-ATPase alpha-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes","volume":"104","author":"Sztul","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.14348\/molcells.2021.0027_bib47","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1600-0854.2009.00955.x","article-title":"ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane","volume":"10","author":"Truschel","year":"2009","journal-title":"Traffic"},{"key":"10.14348\/molcells.2021.0027_bib48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.devcel.2005.09.019","article-title":"The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking","volume":"9","author":"Vaccari","year":"2005","journal-title":"Dev. Cell"},{"key":"10.14348\/molcells.2021.0027_bib49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1242\/dmm.017913","article-title":"Biology and therapy of inherited retinal degenerative disease: insights from mouse models","volume":"8","author":"Veleri","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.14348\/molcells.2021.0027_bib50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/MCB.23.1.150-162.2003","article-title":"Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues","volume":"23","author":"Wagner","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.14348\/molcells.2021.0027_bib51","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1242\/jcs.032615","article-title":"Apical trafficking in epithelial cells: signals, clusters and motors","volume":"122","author":"Weisz","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.14348\/molcells.2021.0027_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jcp.1041200208","article-title":"Endocytosis and exocytosis of protein in capillary endothelium","volume":"120","author":"Williams","year":"1984","journal-title":"J. Cell. Physiol."},{"key":"10.14348\/molcells.2021.0027_bib53","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1006\/exer.2002.1175","article-title":"Systematic analysis of E-, N- and P-cadherin expression in mouse eye development","volume":"74","author":"Xu","year":"2002","journal-title":"Exp. Eye Res."}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/KSMCB\/2021\/044\/KSMCB044-03-05.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823001838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823001838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pdf.medrang.co.kr\/KSMCB\/2021\/044\/KSMCB044-03-05.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T11:01:41Z","timestamp":1724756501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847823001838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1016847823001838"],"URL":"https:\/\/doi.org\/10.14348\/molcells.2021.0027","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14348\/molcells.2021.0027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 THE AUTHORS. Published by Elsevier Inc on behalf of the Korean Society for Molecular and Cellular Biology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}