{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:23:20Z","timestamp":1784089400661,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2019R-1F1A104537913"],"award-info":[{"award-number":["NRF2019R-1F1A104537913"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecules and Cells"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.14348\/molcells.2023.2149","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T03:42:55Z","timestamp":1678419775000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["7\u03b1,25-Dihydroxycholesterol-Induced Oxiapoptophagic Chondrocyte Death via the Modulation of p53-Akt-mTOR Axis in Osteoarthritis Pathogenesis"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-364X","authenticated-orcid":false,"given":"Jeong-Yeon","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2544-8608","authenticated-orcid":false,"given":"Tae-Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1369-3865","authenticated-orcid":false,"given":"Kyeong-Rok","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-4205","authenticated-orcid":false,"given":"HyangI","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-7718","authenticated-orcid":false,"given":"Moon-Chang","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-946X","authenticated-orcid":false,"given":"Do Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-0139","authenticated-orcid":false,"given":"Hong Sung","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-3669","authenticated-orcid":false,"given":"Heung-Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-1663","authenticated-orcid":false,"given":"Sun-Kyoung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-6351","authenticated-orcid":false,"given":"Jae-Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14348\/molcells.2023.2149_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/7651_2018_159","article-title":"Monitoring and measuring mammalian autophagy","volume":"1854","author":"Bhutia","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.14348\/molcells.2023.2149_bib2","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3390\/cancers13102411","article-title":"Targeting reactive oxygen species metabolism to induce myeloma cell death","volume":"13","author":"Caillot","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.14348\/molcells.2023.2149_bib3","doi-asserted-by":"crossref","first-page":"906670","DOI":"10.3389\/fonc.2022.906670","article-title":"Cholesterol and its derivatives: multifaceted players in breast cancer progression","volume":"12","author":"Centonze","year":"2022","journal-title":"Front. Oncol."},{"key":"10.14348\/molcells.2023.2149_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","article-title":"The CH25H-CYP7B1-ROR\u03b1 axis of cholesterol metabolism regulates osteoarthritis","volume":"566","author":"Choi","year":"2019","journal-title":"Nature"},{"key":"10.14348\/molcells.2023.2149_bib5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/cells7120278","article-title":"Autophagy: an essential degradation program for cellular homeostasis and life","volume":"7","author":"Chun","year":"2018","journal-title":"Cells"},{"key":"10.14348\/molcells.2023.2149_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/1756-185X.13061","article-title":"Cholesterol metabolism in pathogenesis of osteoarthritis disease","volume":"20","author":"Farnaghi","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"10.14348\/molcells.2023.2149_bib7","first-page":"194","article-title":"Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models","volume":"9","author":"He","year":"2020","journal-title":"Biology (Basel)"},{"key":"10.14348\/molcells.2023.2149_bib8","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.14348\/molcells.2023.2149_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/BOR.0b013e3283494005","article-title":"Aging and osteoarthritis","volume":"23","author":"Loeser","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.14348\/molcells.2023.2149_bib10","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.14348\/molcells.2023.2149_bib11","first-page":"329635","article-title":"Mitochondria-ros crosstalk in the control of cell death and aging","volume":"2012","author":"Marchi","year":"2012","journal-title":"J. Signal Transduct."},{"key":"10.14348\/molcells.2023.2149_bib12","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.21873\/anticanres.15408","article-title":"Targeting production of reactive oxygen species as an anticancer strategy","volume":"41","author":"Marioli-Sapsakou","year":"2021","journal-title":"Anticancer Res."},{"key":"10.14348\/molcells.2023.2149_bib13","doi-asserted-by":"crossref","first-page":"116786","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"key":"10.14348\/molcells.2023.2149_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcell.2018.00137","article-title":"Beclin 1 phosphorylation - at the center of autophagy regulation","volume":"6","author":"Menon","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.14348\/molcells.2023.2149_bib15","doi-asserted-by":"crossref","first-page":"e25820","DOI":"10.1371\/journal.pone.0025820","article-title":"Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells","volume":"6","author":"Michallet","year":"2011","journal-title":"PLoS One"},{"key":"10.14348\/molcells.2023.2149_bib16","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/cancers12061410","article-title":"The pivotal role of the dysregulation of cholesterol homeostasis in cancer: implications for therapeutic targets","volume":"12","author":"Mok","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.14348\/molcells.2023.2149_bib17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bbrc.2013.11.081","article-title":"Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by \u03b1-tocopherol","volume":"446","author":"Nury","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14348\/molcells.2023.2149_bib18","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1111\/bph.15173","article-title":"Oxiapoptophagy: a type of cell death induced by some oxysterols","volume":"178","author":"Nury","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"Pt B","key":"10.14348\/molcells.2023.2149_bib19","article-title":"25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways","volume":"207","author":"Olivier","year":"2017","journal-title":"Chem. Phys. Lipids"},{"key":"10.14348\/molcells.2023.2149_bib20","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s41467-019-09453-x","article-title":"Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response","volume":"10","author":"Pokharel","year":"2019","journal-title":"Nat. Commun."},{"key":"10.14348\/molcells.2023.2149_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4196\/kjpp.2020.24.3.249","article-title":"Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes","volume":"24","author":"Seo","year":"2020","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.14348\/molcells.2023.2149_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphar.2015.00060","article-title":"7\u03b1, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases","volume":"6","author":"Sun","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.14348\/molcells.2023.2149_bib23","doi-asserted-by":"crossref","first-page":"561459","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm."}],"container-title":["Molecules and Cells"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/KSMCB\/2022\/046\/KSMCB046-04-07.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823000316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1016847823000316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pdf.medrang.co.kr\/KSMCB\/2022\/046\/KSMCB046-04-07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T17:55:41Z","timestamp":1760896541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1016847823000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1016847823000316"],"URL":"https:\/\/doi.org\/10.14348\/molcells.2023.2149","relation":{},"ISSN":["1016-8478"],"issn-type":[{"value":"1016-8478","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7\u03b1,25-Dihydroxycholesterol-Induced Oxiapoptophagic Chondrocyte Death via the Modulation of p53-Akt-mTOR Axis in Osteoarthritis Pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Molecules and Cells","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14348\/molcells.2023.2149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 THE AUTHORS. Published by Elsevier Inc on behalf of the Korean Society for Molecular and Cellular Biology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}