{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:38Z","timestamp":1792007618945,"version":"4.4.0"},"reference-count":25,"publisher":"Korean Society of Ultrasound in Medicine","issue":"5","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371973"],"award-info":[{"award-number":["82371973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171954"],"award-info":[{"award-number":["82171954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Committee for Science and Technology","award":["23410713000"],"award-info":[{"award-number":["23410713000"]}]},{"name":"Shanghai sixth peoples hospital","award":["Ynyq202303"],"award-info":[{"award-number":["Ynyq202303"]}]},{"name":"Shanghai sixth peoples hospital","award":["Ynhg202128"],"award-info":[{"award-number":["Ynhg202128"]}]},{"name":"Shanghai Key Clinical Research Center","award":["2023ZZ02006"],"award-info":[{"award-number":["2023ZZ02006"]}]}],"content-domain":{"domain":["e-ultrasonography.org"],"crossmark-restriction":true},"short-container-title":["Ultrasonography"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>Purpose: This study aimed to establish a novel acne scoring system (GAGS-HFUS) that combined the Global Acne Grading System (GAGS) with high-frequency ultrasound (HFUS), and to evaluate its predictive value for unfavorable treatment response in patients who have moderate-to-severe acne.Methods: This prospective study recruited consecutive patients with mild-to-severe acne vulgaris. The GAGS-HFUS was developed based on the HFUS-detected morphological characteristics of acne and the GAGS facial region classification. Acne severity was assessed using both ultrasonic scales (the GAGS-HFUS, Sonographic Scoring System for Acne [SSSA], and Sonographic Scoring of Acne [SOS-Acne]) and a clinical scale (the Investigator Global Assessment [IGA]). Three months of followup were conducted in a subgroup of 34 patients with moderate-to-severe acne treated with oral isotretinoin. Univariate and multivariate Poisson regression analyses were conducted to determine the predictive value of GAGS-HFUS for unfavorable treatment response in this subgroup.Results: Overall, 60 patients with mild-to-severe acne (mean age, 24 years; range, 16 to 34 years; 25 males) were enrolled. The GAGS-HFUS demonstrated substantial agreement with SOS-Acne (Spearman rank correlation coefficient [R&amp;lt;sub&amp;gt;s&amp;lt;\/sub&amp;gt;], 0.864; kappa, 0.713) and IGA (R&amp;lt;sub&amp;gt;s&amp;lt;\/sub&amp;gt;, 0.837; kappa, 0.660). In the follow-up cohort of 34 patients with moderate-to-severe acne, GAGS-HFUS score was identified as an independent predictor of unfavorable treatment response (risk ratio, 1.125; P=0.002). Its predictive performance (area under the receiver operating characteristic curve, 0.936; P&amp;lt;0.001) was superior to those of IGA and SOS-Acne.Conclusion: GAGS-HFUS is an independent predictor of unfavorable treatment response in patients with moderate-to-severe acne, underscoring its value in the strategic management of acne.<\/jats:p>","DOI":"10.14366\/usg.25077","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T05:27:38Z","timestamp":1755667658000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.14366\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integration of high-frequency ultrasound with the Global Acne Grading System for prediction of treatment efficiency in acne vulgaris"],"prefix":"10.14366","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7310-6817","authenticated-orcid":true,"given":"Luqian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-1075","authenticated-orcid":true,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-7157","authenticated-orcid":true,"given":"Jingyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8613-5982","authenticated-orcid":true,"given":"Yimin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-0592","authenticated-orcid":true,"given":"Di","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5473","reference":[{"key":"ref1","first-page":"1006","volume-title":"Guidelines 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management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne","author":"Thiboutot","year":"2018"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.03.032"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2024.111513"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1051862"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-1279"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00746-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15710"}],"container-title":["Ultrasonography"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-ultrasonography.org\/upload\/usg-25077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-ultrasonography.org\/journal\/view.php?doi=10.14366\/usg.25077","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-ultrasonography.org\/upload\/usg-25077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T06:10:11Z","timestamp":1756966211000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-ultrasonography.org\/journal\/view.php?doi=10.14366\/usg.25077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"URL":"https:\/\/doi.org\/10.14366\/usg.25077","relation":{},"ISSN":["2288-5919","2288-5943"],"issn-type":[{"value":"2288-5919","type":"print"},{"value":"2288-5943","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"2025-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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