{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:38:26Z","timestamp":1762238306180,"version":"build-2065373602"},"reference-count":33,"publisher":"Korean Society of Ultrasound in Medicine","issue":"6","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-ultrasonography.org"],"crossmark-restriction":true},"short-container-title":["Ultrasonography"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Purpose: The present study aimed to evaluate changes in renal stiffness in primary hyperparathyroidism (PHPT) using shear-wave elastography (SWE), and to assess treatmentrelated improvements following microwave ablation (MWA).Methods: This retrospective study included 53 PHPT patients (mean age, 56.4\u00b110.8 years; 48 women, 5 men) and 70 healthy controls (mean age, 54.5\u00b19.7 years; 58 women, 12 men). Baseline renal SWE values (measured in the renal cortex) and biochemical parameters (parathyroid hormone [PTH], calcium, phosphate) were compared between groups. The control group served only for baseline comparisons and was not followed longitudinally. In the patient group, posttreatment SWE and biochemical changes were assessed at 1 day, 1 month, 3 months, 6 months, and 1 year. Statistical analysis included paired and independent t-tests, while regression analysis identified predictors of renal stiffness.Results: Baseline SWE values were higher in PHPT patients than in controls (9.16\u00b12.64 kPa vs. 5.02\u00b10.63 kPa, P&amp;lt;0.01). After MWA, SWE values significantly decreased (1-year mean, 5.15\u00b11.19 kPa; P&amp;lt;0.01). PTH and calcium levels also improved post-treatment (P&amp;lt;0.01). Regression analysis showed that PTH (\u03b2=0.02, P&amp;lt;0.01) and calcium (\u03b2=1.82, P=0.018) independently predicted renal stiffness.Conclusion: Reductions in renal stiffness and improvements in biochemical parameters were observed in PHPT patients following MWA. These preliminary findings suggest that SWE may have potential as a non-invasive tool for assessing and monitoring renal involvement in PHPT.<\/jats:p>","DOI":"10.14366\/usg.25104","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T01:39:02Z","timestamp":1760924342000},"page":"448-457","update-policy":"https:\/\/doi.org\/10.14366\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of renal stiffness in primary hyperparathyroidism using shear-wave elastography and changes after microwave ablation"],"prefix":"10.14366","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3482","authenticated-orcid":true,"given":"H\u00fcseyin 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