{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:23:04Z","timestamp":1768987384382,"version":"3.49.0"},"reference-count":0,"publisher":"Journal of Biological Methods","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder"],"abstract":"<jats:p>The botulinum neurotoxin type A (BoNT\/A) is a neurotoxin produced by Clostridium botulinum. It causes botulism and represents the most powerful natural poison. In urological practice, the indications for BoNT\/A therapy include neurogenic detrusor overactivity (NDO), idiopathic overactive bladder (OAB) or idiopathic detrusor overactivity (IDO), detrusor-sphincter dyssynergia (DSD), interstitial cystitis\/bladder pain syndrome (IC\/BPS), urinary tract infections (UTI), benign prostatic hyperplasia (BPH), and, more recently, chronic prostatic pain (CPP). BoNT\/A is not only conducive to the treatment of muscle spasticity but also effectively works on hyperalgesia associated with various disorders of the lower urinary tract, thanks to its anti-nociceptive properties. While Botox&amp;reg; (Allergan Inc., Irvine, CA) is currently being used across the globe, we have been using Chinese BoNT\/A for many years for the treatment of DSD, NDO, idiopathic OAB, IC\/BPS, BPH and UTI. Our experience showed that Chinese BoNT\/A was as good as other BoNT\/A products in terms of efficacy, safety, and tolerability. In this study, we explored the current and potential applications of Chinese BoNT\/A in urology, and reviewed the background information regarding the toxin.<\/jats:p>","DOI":"10.14440\/bladder.2022.847","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:48:10Z","timestamp":1663202890000},"page":"1","source":"Crossref","is-referenced-by-count":2,"title":["Chinese botulinum toxin A for the treatment of lower urinary tract dysfunction: It works just as well"],"prefix":"10.14440","volume":"9","author":[{"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5574","published-online":{"date-parts":[[2022,9,14]]},"container-title":["Bladder"],"original-title":[],"link":[{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/2024042315053967bcc3192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/2024042315053967bcc3192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T08:27:59Z","timestamp":1725870479000},"score":1,"resource":{"primary":{"URL":"https:\/\/polscientific.com\/journal\/Bladder\/9\/1\/10.14440\/bladder.2022.847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,9,14]]}},"URL":"https:\/\/doi.org\/10.14440\/bladder.2022.847","relation":{},"ISSN":["2327-2120"],"issn-type":[{"value":"2327-2120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]}}}