{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:41:32Z","timestamp":1792024892054,"version":"4.4.0"},"reference-count":0,"publisher":"Journal of Biological Methods","issue":"2","license":[{"start":{"date-parts":[[1970,1,1]],"date-time":"1970-01-01T00:00:00Z","timestamp":0},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder"],"abstract":"<jats:p>Objectives: Pentosan Polysulfate (PPS) is the only oral treatment for interstitial cystitis (IC)-bladder pain syndrome (BPS) approved by the World Health Organization. Self-evaluation scales can provide more objective results on pre- and post-treatment satisfaction. The aim of this study was to investigate the effect of pentosan polysulfate treatment on symptoms in IC-BPS patients.Methods: This study included 37 adult male and female patients with IC-BPS who reported pain, urinary urgency, polyurea, and nocturia without urinary tract infection for a minimum of six months prior to the study and were taking 300 mg\/day oral pentosan polysulfate. Pre- and post-treatment symptoms, Interstitial Cystitis Symptom Index (ICSI) Scores, quality of life (QoL) scores (1\u20124), and satisfaction conditions were examined.Results: Following the application of inclusion and exclusion criteria, mean age of 37 suitable patients was 46.0&amp;plusmn;11.9 years and 27% (10 individuals) of the patients were male. Pre-treatment, ICSI scores, and measures of satisfaction degree and QoL increased significantly after the treatment (p&lt;0.001). Adverse reaction was detected in two patients (5.4%) among the patients treated with pentosan polysulfate.Conclusions: Oral pentosan polysulfate for the treatment of interstitial cystitis\/bladder pain syndrome treatment could achieve recovery in symptoms, increase Interstitial Cystitis Symptom Index score and improve quality of life and patient satisfaction.<\/jats:p>","DOI":"10.14440\/bladder.2023.866","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T07:24:54Z","timestamp":1694762694000},"page":"1","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Pentosan Polysulfate Treatment in Patients with Interstitial Cystitis\/Bladder Pain Syndrome"],"prefix":"10.14440","volume":"10","author":[{"given":"Mehmet G\u00fcrkan","family":"Ar\u0131kanv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basri","family":"\u00c7ak\u0131ro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5574","published-online":{"date-parts":[[1970,1,1]]},"container-title":["Bladder"],"original-title":[],"link":[{"URL":"https:\/\/polscientific.com\/bladder\/index.php\/bladder\/article\/download\/866\/145","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/20240412203550532683898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/20240412203550532683898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T05:39:42Z","timestamp":1744695582000},"score":1,"resource":{"primary":{"URL":"https:\/\/polscientific.com\/journal\/Bladder\/10\/2\/10.14440\/bladder.2023.866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,12,31]]}},"URL":"https:\/\/doi.org\/10.14440\/bladder.2023.866","relation":{},"ISSN":["2327-2120"],"issn-type":[{"value":"2327-2120","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,1,1]]}}}