{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:32:37Z","timestamp":1726101157050},"reference-count":0,"publisher":"Journal of Biological Methods","issue":"2","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder"],"abstract":"<jats:p>Background: Photobiomodulation (PBM) may stabilize autonomic neural drive from the pontine micturition Center to the urinary bladder in individuals with overactive bladder (OAB) symptoms. Methods: A safety profile study preceded a single-case experimental design with repeated measures across subjects to establish the safety and effect direction of PBM to modify symptoms in patients with OAB. Results: No adverse events occurred with PBM, specifically blood pressure remained unchanged. Urinary frequency improved significantly during the intervention and at follow-up. PBM therapy was associated with a meaningful impact on OAB-related quality of life and a small to medium-to-high effect size on OAB symptom severity. Conclusion: Nasal application of PBM is safe and may impact OAB symptoms. A controlled trial of PBM in patients with lower urinary tract symptoms is warranted.<\/jats:p>","DOI":"10.14440\/bladder.2024.0014","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:19:18Z","timestamp":1726049958000},"page":"e21200007","source":"Crossref","is-referenced-by-count":0,"title":["A pilot study on the potential of photobiomodulation to safely modify symptoms of an overactive bladder"],"prefix":"10.14440","volume":"11","author":[{"given":"Wendy F","family":"Bower","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Michael","family":"Whishaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Biros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Baldrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary P","family":"Galea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5574","published-online":{"date-parts":[[2024,9,11]]},"container-title":["Bladder"],"original-title":[],"link":[{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/20240911162341869ee2097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/20240911162341869ee2097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:19:18Z","timestamp":1726049958000},"score":1,"resource":{"primary":{"URL":"https:\/\/polscientific.com\/journal\/Bladder\/11\/2\/10.14440\/bladder.2024.0014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.14440\/bladder.2024.0014","relation":{},"ISSN":["2327-2120"],"issn-type":[{"value":"2327-2120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]}}}