{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:22:01Z","timestamp":1768872121470,"version":"3.49.0"},"reference-count":0,"publisher":"Journal of Biological Methods","issue":"2","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBM"],"abstract":"<jats:p>Background: Gastric adenocarcinoma, the malignant proliferation of glandular cells in stomach epithelium, is a type of gastric cancer with a statistical disease burden of the fifth most common cancer globally and the 17th most common malignancy in the United Kingdom. Prognosis varies with stage (I&amp;ndash;IV), with stages I&amp;ndash;III showing promising 5-year survival rates up to 71.8%, warranting timely diagnosis and treatment. Surgery is the gold-standard treatment; however, due to complex tumor pathophysiology, there is growing interest in the use of multimodal therapies. Specifically, the combination of surgery and adjuvant chemotherapy has become a key focus of the treatment for stages I&amp;ndash;III gastric adenocarcinoma. Objective: The study reviewed patients with stages I&amp;ndash;III (non-advanced) gastric adenocarcinoma to assess whether adjuvant chemotherapy combined with surgery provides better disease-free\/disease-specific\/cause-specific survival, overall survival, and reduced recurrence rates\/improved recurrence-free survival, compared to surgery alone. Analyzed were 17 English-language, full-text, levels I&amp;ndash;III peer-reviewed studies from MEDLINE and Embase from the past 10 years were analyzed. No age\/sex\/ethnicity\/country restrictions were applied, and the dimension of interest was limited to stages I&amp;ndash;III gastric adenocarcinoma patients who underwent tumor resection through surgery and received chemotherapy as the only adjuvant therapy. Seven (41.2%) studies have more than one statistically significant outcome measure supporting the benefit of adjuvant chemotherapy in combination with surgery over surgery alone. Ten (58.8%) studies showed no statistically significant benefit of adjuvant chemotherapy. Conclusion: The findings contrasted with previous large-scale meta-analyses, which were limited by sample size and biases in individual studies reviewed. Continued research, incorporating advances in surgical techniques and new chemotherapeutic combinations, is necessary to ascertain best-tailored treatments for gastric adenocarcinoma.<\/jats:p>","DOI":"10.14440\/jbm.2025.0135","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T01:06:52Z","timestamp":1745370412000},"page":"e99010060","source":"Crossref","is-referenced-by-count":1,"title":["Survival outcomes in patients with stages I\u2013III gastric adenocarcinoma treated with surgery alone versus surgery plus adjuvant chemotherapy: A systematic review"],"prefix":"10.14440","volume":"12","author":[{"given":"Naveena Kaur","family":"Rikhraj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5574","published-online":{"date-parts":[[2025,4,18]]},"container-title":["Journal of Biological Methods"],"original-title":[],"link":[{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/202505301421262708e4341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/web-api.polscientific.com\/uploads\/file\/asp\/202505301421262708e4341.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:39:24Z","timestamp":1749101964000},"score":1,"resource":{"primary":{"URL":"https:\/\/polscientific.com\/journal\/JBM\/12\/2\/10.14440\/jbm.2025.0135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,5,30]]}},"URL":"https:\/\/doi.org\/10.14440\/jbm.2025.0135","relation":{},"ISSN":["2326-9901"],"issn-type":[{"value":"2326-9901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}