{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:42:08Z","timestamp":1790484128377,"version":"4.1.0"},"reference-count":32,"publisher":"Texas Heart Institute Journal","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The epidemiologic profile of infective endocarditis has changed substantially over the past few years, especially in industrialized countries. Our study evaluates the clinical and pathologic characteristics of infective endocarditis patients treated by cardiac surgery in China during a 12-year period.<\/jats:p>\n        <jats:p>We retrospectively evaluated 220 surgically treated infective endocarditis patients and analyzed their changes from the beginning of 1998 through 2009. The mean age of the patients increased from 36.9 to 42.7 years during those 12 years (P=0.036). The chief predisposing disease was congenital heart disease (32.8%), rather than rheumatic heart disease (13.2%); this rate did not change significantly during the 12 years. The prevalent congenital lesion was bicuspid aortic valve, the rate of which (55.6%) increased significantly over the 3 time intervals studied (P=0.016). The frequency of infective endocarditis after non-dental surgical and nonsurgical intervention was significantly greater (23.3%) during 1998 through 2001, compared with the 2 intervals that followed (9%; P=0.019). <jats:italic>Streptococcus viridans<\/jats:italic> was the most frequent causative agent overall (25.6%). Forty-seven of the 220 patients (21.4%) carried the clinical diagnosis of some other form of heart disease before surgery, but at surgery they were found to have infective endocarditis as the fundamental disease process. Of 47 patients, 33 (70.2%) had either very small or no vegetations but had focal necrosis and inflammation of valve tissue that supported the diagnosis of infective endocarditis.<\/jats:p>","DOI":"10.14503\/thij-13-3468","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T20:04:57Z","timestamp":1412193897000},"page":"491-498","source":"Crossref","is-referenced-by-count":14,"title":["Changing Profile of Infective Endocarditis: A Clinicopathologic Study of 220 Patients in a Single Medical Center from 1998 through 2009"],"prefix":"10.14503","volume":"41","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielin","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"9403","key":"i0730-2347-41-5-491-b1","series-title":"Lancet","first-page":"139","article-title":"Infective endocarditis","volume":"363","year":"2004","unstructured":"Moreillon\n              P\n            , QueYA.\n          Infective endocarditis. Lancet2004; 363(9403):139\u201349."},{"issue":"3","key":"i0730-2347-41-5-491-b2","series-title":"Clin Infect Dis","first-page":"313","article-title":"Infective endocarditis","volume":"17","year":"1993","unstructured":"Bayer\n              AS.\n            \n          \n          Infective endocarditis. Clin Infect Dis1993;17(3): 313\u201322."},{"issue":"18","key":"i0730-2347-41-5-491-b3","series-title":"N Engl J Med","first-page":"1318","article-title":"Infective endocarditis in adults","volume":"345","year":"2001","unstructured":"Mylonakis\n              E\n            , CalderwoodSB.\n          Infective endocarditis in adults. 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A retrospective review of 228 episodes of infective endocarditis where rheumatic valvular disease is still common. Int J Antimicrob Agents2001;18(1):1\u20137."},{"issue":"3","key":"i0730-2347-41-5-491-b10","series-title":"Int J Infect Dis","first-page":"163","article-title":"Infective endocarditis: a five-year experience at a tertiary care hospital in Pakistan","volume":"8","year":"2004","unstructured":"Tariq\n              M\n            , AlamM, MunirG, KhanMA, SmegoRAJr.\n          Infective endocarditis: a five-year experience at a tertiary care hospital in Pakistan. Int J Infect Dis2004;8(3):163\u201370."},{"issue":"5","key":"i0730-2347-41-5-491-b11","series-title":"Infection","first-page":"527","article-title":"Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian Study on Endocarditis","volume":"40","year":"2012","unstructured":"Leone\n              S\n            , RavasioV, Durante-MangoniE, CrapisM, CarosiG, ScottonPG, et al. 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Clin Microbiol Infect2004;10(6):556\u201361."},{"issue":"2","key":"i0730-2347-41-5-491-b25","series-title":"J Heart Valve Dis","first-page":"200","article-title":"Native versus primary prosthetic valve endocarditis: comparison of clinical features and long-term outcome in 353 patients","volume":"13","year":"2004","unstructured":"Romano\n              G\n            , CarozzaA, DellaCorteA, DeSantoLS, AmarelliC, TorellaM, et al. Native versus primary prosthetic valve endocarditis: comparison of clinical features and long-term outcome in 353 patients. J Heart Valve Dis2004;13(2):200\u20139."},{"issue":"5","key":"i0730-2347-41-5-491-b26","series-title":"Am J Trop Med Hyg","first-page":"503","article-title":"High prevalence of Bartonella quintana endocarditis in Sfax, Tunisia","volume":"72","year":"2005","unstructured":"Znazen\n              A\n            , RolainJM, HammamiN, KammounS, HammamiA, RaoultD.\n          High prevalence of Bartonella quintana endocarditis in Sfax, Tunisia. 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