{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:23:44Z","timestamp":1782602624336,"version":"3.54.5"},"reference-count":10,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"A 46-year-old man with a history of paranoid schizophrenia was admitted with a recurrence of psychotic symptoms. Improvement was noted after the initiation of clozapine. After 2 weeks of clozapine therapy, chest pressure and abnormal cardiac biomarkers (in the presence of a normal coronary angiogram) raised suspicion of myocarditis. That diagnosis was confirmed by means of cardiac magnetic resonance imaging. Discontinuation of the clozapine led to resolution of the cardiac symptoms. Clozapine-induced myocarditis is rare and can be missed for lack of specific clinical findings. In order to prevent disease progression and a possibly fatal outcome, early recognition of the condition and prompt discontinuation of clozapine are necessary.<\/jats:p>","DOI":"10.14503\/thij-13-3633","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T18:32:40Z","timestamp":1427913160000},"page":"155-157","source":"Crossref","is-referenced-by-count":18,"title":["Clozapine-Induced Myocarditis: Recognizing a Potentially Fatal Adverse Reaction"],"prefix":"10.14503","volume":"42","author":[{"given":"Jennifer L.","family":"Hatton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"1","key":"i0730-2347-42-2-155-b1","series-title":"Drug Saf","first-page":"47","article-title":"Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993\u20132003","volume":"30","year":"2007","unstructured":"Haas\n SJ, \n \n Hill\n R, \n \n Krum\n H, \n \n Liew\n D, \n \n Tonkin\n A, \n \n Demos\n L, \n \n et al. Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993\u20132003. Drug Saf2007;30(1):47\u201357."},{"issue":"9193","key":"i0730-2347-42-2-155-b2","series-title":"Lancet","first-page":"1841","article-title":"Myocarditis and cardiomyopathy associated with clozapine","volume":"354","year":"1999","unstructured":"Kilian\n JG, \n \n Kerr\n K, \n \n Lawrence\n C, \n \n Celermajer\n DS. \n \n Myocarditis and cardiomyopathy associated with clozapine. Lancet1999; 354(9193):1841\u20135."},{"issue":"1","key":"i0730-2347-42-2-155-b3","series-title":"Neuropsychopharmacology","first-page":"29","article-title":"Mechanism of peripheral noradrenergic stimulation by clozapine","volume":"20","year":"1999","unstructured":"Elman\n I, \n \n Goldstein\n DS, \n \n Eisenhofer\n G, \n \n Folio\n J, \n \n Malhotra\n AK, \n \n Adler\n CM, \n \n et al. Mechanism of peripheral noradrenergic stimulation by clozapine. 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Circulation2004;109 (10):1250\u20138."},{"issue":"11","key":"i0730-2347-42-2-155-b5","series-title":"J Am Coll Cardiol","first-page":"1815","article-title":"Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches","volume":"45","year":"2005","unstructured":"Abdel-Aty\n H, \n \n Boye\n P, \n \n Zagrosek\n A, \n \n Wassmuth\n R, \n \n Kumar\n A, \n \n Messroghli\n D, \n \n et al. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol2005;45(11):1815\u201322."},{"issue":"11","key":"i0730-2347-42-2-155-b6","series-title":"J Am Coll Cardiol","first-page":"1823","article-title":"Cardiovascular magnetic resonance for the diagnosis of acute myocarditis: prospects for detecting myocardial inflammation","volume":"45","year":"2005","unstructured":"Liu\n PP, \n \n Yan\n AT. \n \n Cardiovascular magnetic resonance for the diagnosis of acute myocarditis: prospects for detecting myocardial inflammation. J Am Coll Cardiol2005;45(11):1823\u20135."},{"issue":"17","key":"i0730-2347-42-2-155-b7","series-title":"J Am Coll Cardiol","first-page":"1475","article-title":"Cardiovascular magnetic resonance in myocarditis: a JACC white paper","volume":"53","year":"2009","unstructured":"Friedrich\n MG, \n \n Sechtem\n U, \n \n Schulz-Menger\n J, \n \n Holmvang\n G, \n \n Alakija\n P, \n \n Cooper\n LT, \n \n et al. Cardiovascular magnetic resonance in myocarditis: a JACC white paper. J Am Coll Cardiol2009;53(17):1475\u201387."},{"issue":"19","key":"i0730-2347-42-2-155-b8","series-title":"J Am Coll Cardiol","first-page":"1914","article-title":"The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology","volume":"50","year":"2007","unstructured":"Cooper\n LT, \n \n Baughman\n KL, \n \n Feldman\n AM, \n \n Frustaci\n A, \n \n Jessup\n M, \n \n Kuhl\n U, \n \n et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. J Am Coll Cardiol2007;50(19):1914\u201331."},{"issue":"4","key":"i0730-2347-42-2-155-b9","series-title":"J Clin Psychopharmacol","first-page":"382","article-title":"Myocarditis related to clozapine treatment","volume":"21","year":"2001","unstructured":"Hagg\n S, \n \n Spigset\n O, \n \n Bate\n A, \n \n Soderstrom\n TG. \n \n Myocarditis related to clozapine treatment. J Clin Psychopharmacol2001;21 (4):382\u20138."},{"issue":"2\u20133","key":"i0730-2347-42-2-155-b10","series-title":"Schizophr Res","first-page":"180","article-title":"When can patients with potentially life-threatening adverse effects be rechallenged with clozapine? A systematic review of the published literature","volume":"134","year":"2012","unstructured":"Manu\n P, \n \n Sarpal\n D, \n \n Muir\n O, \n \n Kane\n JM, \n \n Correll\n CU. \n \n When can patients with potentially life-threatening adverse effects be rechallenged with clozapine? A systematic review of the published literature. Schizophr Res2012;134(2\u20133):180\u20136."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/2\/article-p155.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/42\/2\/155\/1968340\/thij-13-3633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/2\/article-p155.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/2\/article-p155.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:31:58Z","timestamp":1730993518000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/2\/article-p155.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":10,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.14503\/thij-13-3633","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}