{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:18:03Z","timestamp":1784816283320,"version":"3.55.0"},"reference-count":25,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>This retrospective study attempted to establish the prevalence of multiple-valve involvement in Marfan syndrome and to compare echocardiographic with histopathologic findings in Marfan patients undergoing valvular or aortic surgery.<\/jats:p>\n        <jats:p>We reviewed echocardiograms of 73 Marfan patients who underwent cardiovascular surgery from January 2004 through October 2009. Tissue histology was available for comparison in 29 patients.<\/jats:p>\n        <jats:p>Among the 73 patients, 66 underwent aortic valve replacement or the Bentall procedure. Histologic findings were available in 29 patients, all of whom had myxomatous degeneration. Of 63 patients with moderate or severe aortic regurgitation as determined by echocardiography, 4 had thickened aortic valves. The echocardiographic findings in 18 patients with mitral involvement included mitral prolapse in 15. Of 11 patients with moderate or severe mitral regurgitation as determined by echocardiography, 4 underwent mitral valve repair and 7 mitral valve replacement. Histologic findings among mitral valve replacement patients showed thickened valve tissue and myxomatous degeneration. Tricuspid involvement was seen echocardiographically in 8 patients, all of whom had tricuspid prolapse. Two patients had severe tricuspid regurgitation, and both underwent repair. Both mitral and tricuspid involvement were seen echocardiographically in 7 patients.<\/jats:p>\n        <jats:p>Among the 73 patients undergoing cardiac surgery for Marfan syndrome, 66 had moderate or severe aortic regurgitation, although their valves manifested few histologic changes. Eighteen patients had mitral involvement (moderate or severe mitral regurgitation, prolapse, or both), and 8 had tricuspid involvement. Mitral valves were most frequently found to have histologic changes, but the tricuspid valve was invariably involved.<\/jats:p>","DOI":"10.14503\/thij-13-3848","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T17:19:49Z","timestamp":1423502389000},"page":"30-34","source":"Crossref","is-referenced-by-count":19,"title":["Echocardiographic versus Histologic Findings in Marfan Syndrome"],"prefix":"10.14503","volume":"42","author":[{"given":"Xiaoyan","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.V. (Ian)","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"11","key":"i0730-2347-42-1-30-b1","series-title":"J Clin Invest","first-page":"1543","article-title":"Marfan syndrome and mitral valve prolapse","volume":"114","year":"2004","unstructured":"Weyman\n              AE, \n            \n              Scherrer-Crosbie\n              M.\n          \n          Marfan syndrome and mitral valve prolapse. 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Nat Genet2004;36(8):855\u201360."},{"issue":"2","key":"i0730-2347-42-1-30-b8","series-title":"J Am Coll Cardiol","first-page":"329","article-title":"Long-term outcome in patients with Marfan syndrome: is aortic dissection the only cause of sudden death?","volume":"41","year":"2003","unstructured":"Yetman\n              AT, \n            \n              Bornemeier\n              RA, \n            \n              McCrindle\n              BW.\n          \n          Long-term outcome in patients with Marfan syndrome: is aortic dissection the only cause of sudden death?\n          J Am Coll Cardiol\n          2003;41 (2):329\u201332."},{"issue":"7","key":"i0730-2347-42-1-30-b9","series-title":"Genet Med","first-page":"401","article-title":"A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome","volume":"8","year":"2006","unstructured":"De Backer\n              J, \n            \n              Loeys\n              B, \n            \n              Devos\n              D, \n            \n              Dietz\n              H, \n            \n              De Sutter\n              J, \n            \n              De Paepe\n              A.\n          \n          A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome. Genet Med2006;8(7):401\u20138."},{"issue":"8","key":"i0730-2347-42-1-30-b10","series-title":"Ital Heart J Suppl","first-page":"647","article-title":"Prevalence of cardiovascular manifestations in Marfan syndrome [in Italian]","volume":"5","year":"2004","unstructured":"Porciani\n              MC, \n            \n              Attanasio\n              M, \n            \n              Lepri\n              V, \n            \n              Lapini\n              I, \n            \n              Demarchi\n              G, \n            \n              Padeletti\n              L\n            \n          , et al. Prevalence of cardiovascular manifestations in Marfan syndrome [in Italian]. 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Am J Med Genet1996;62(4):417\u201326."},{"issue":"6","key":"i0730-2347-42-1-30-b13","series-title":"Ann Thorac Surg","first-page":"1922","article-title":"Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications","volume":"67","year":"1999","unstructured":"Coady\n              MA, \n            \n              Rizzo\n              JA, \n            \n              Hammond\n              GL, \n            \n              Kopf\n              GS, \n            \n              Elefteriades\n              JA.\n          \n          Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications. 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J Am Soc Echocardiogr2003;16(7):777\u2013802."},{"issue":"3","key":"i0730-2347-42-1-30-b15","series-title":"Eur J Echocardiogr","first-page":"223","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 1: aortic and pulmonary regurgitation (native valve disease)","volume":"11","year":"2010","unstructured":"Lancellotti\n              P, \n            \n              Tribouilloy\n              C, \n            \n              Hagendorff\n              A, \n            \n              Moura\n              L, \n            \n              Popescu\n              BA, \n            \n              Agricola\n              E\n            \n          , et al. European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 1: aortic and pulmonary regurgitation (native valve disease). 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