{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:15:42Z","timestamp":1771049742672,"version":"3.50.1"},"reference-count":8,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Ochronosis, an autosomal recessive metabolic disorder, causes an excess of homogentisic acid that results in adverse pigmentation, calcification, and inflammation of cartilaginous and other tissues. Cardiovascular abnormalities are less frequently reported than are other manifestations. In rare cases, ochronosis can cause valvular heart disease. We report the case of a 72-year-old man with aortic stenosis and mitral insufficiency who was diagnosed with ochronosis while undergoing surgical aortic and mitral valve replacement. We discuss the history and surgical management of alkaptonuric ochronosis.<\/jats:p>","DOI":"10.14503\/thij-14-4138","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T17:19:49Z","timestamp":1423502389000},"page":"84-86","source":"Crossref","is-referenced-by-count":10,"title":["Ochronotic Involvement of the Aortic and Mitral Valves in a 72-Year-Old Man"],"prefix":"10.14503","volume":"42","author":[{"given":"Atakan","family":"Atalay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Gocen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuksel","family":"Basturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Kozanoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafize","family":"Yaliniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"26","key":"i0730-2347-42-1-84-b1","series-title":"N Engl J Med","first-page":"2111","article-title":"Natural history of alkaptonuria","volume":"347","year":"2002","unstructured":"Phornphutkul\n              C, \n            \n              Introne\n              WJ, \n            \n              Perry\n              MB, \n            \n              Bernardini\n              I, \n            \n              Murphey\n              MD, \n            \n              Fitzpatrick\n              DL\n            \n          , et al. Natural history of alkaptonuria. N Engl J Med2002;347(26):2111\u201321."},{"issue":"11","key":"i0730-2347-42-1-84-b2","series-title":"An Med Interna","first-page":"583","article-title":"Ochronosis: a case report with multisystemic affectation, including pericardium [in Spanish]","volume":"19","year":"2002","unstructured":"Cobos Soler\n              FJ, \n            \n              Molero Cabrilla\n              R.\n          \n          Ochronosis: a case report with multisystemic affectation, including pericardium [in Spanish]. An Med Interna2002;19(11):583\u20135."},{"issue":"10","key":"i0730-2347-42-1-84-b3","series-title":"Arch Pathol Lab Med","first-page":"991","article-title":"Cardiovascular ochronosis","volume":"111","year":"1987","unstructured":"Gaines\n              JJ\n              Jr\n            , PaiGM.\n          Cardiovascular ochronosis. Arch Pathol Lab Med1987;111(10):991\u20134."},{"issue":"4303","key":"i0730-2347-42-1-84-b4","series-title":"Science","first-page":"566","article-title":"Biochemical identification of homogentisic acid pigment in an ochronotic Egyptian mummy","volume":"197","year":"1977","unstructured":"Stenn\n              FF, \n            \n              Milgram\n              JW, \n            \n              Lee\n              SL, \n            \n              Weigand\n              RJ, \n            \n              Veis\n              A.\n          \n          Biochemical identification of homogentisic acid pigment in an ochronotic Egyptian mummy. Science1977;197(4303):566\u20138."},{"key":"i0730-2347-42-1-84-b5","series-title":"Z Ration Med","first-page":"130","article-title":"Ueber das Alcapton: ein neuer Beitrag zur Frage: welche Stoffe des Harns k\u00f6nnen Kupferreduction bewirken [in German]?","volume":"7","year":"1859","unstructured":"Boedeker\n              C.\n          \n          Ueber das Alcapton: ein neuer Beitrag zur Frage: welche Stoffe des Harns k\u00f6nnen Kupferreduction bewirken [in German]?\n          Z Ration Med\n          1859;7:130\u201345."},{"key":"i0730-2347-42-1-84-b6","series-title":"Z Physiol Chem","first-page":"228","article-title":"Ueber das Wesen der Alkaptonurie [in German]","volume":"15","year":"1891","unstructured":"Wolkow\n              M, \n            \n              Baumann\n              E.\n          \n          Ueber das Wesen der Alkaptonurie [in German]. Z Physiol Chem1891;15:228\u201385."},{"issue":"5","key":"i0730-2347-42-1-84-b7","series-title":"J Thorac Cardiovasc Surg","first-page":"788","article-title":"Cardiac manifestations of ochronosis","volume":"72","year":"1976","unstructured":"Gould\n              L, \n            \n              Reddy\n              CV, \n            \n              DePalma\n              D, \n            \n              De Martino\n              A, \n            \n              Kalish\n              PE.\n          \n          Cardiac manifestations of ochronosis. J Thorac Cardiovasc Surg1976;72(5):788\u201391."},{"issue":"2","key":"i0730-2347-42-1-84-b8","series-title":"J Card Surg","first-page":"182","article-title":"Ochronosis and aortic valve stenosis","volume":"21","year":"2006","unstructured":"Butany\n              JW, \n            \n              Naseemuddin\n              A, \n            \n              Moshkowitz\n              Y, \n            \n              Nair\n              V.\n          \n          Ochronosis and aortic valve stenosis. J Card Surg2006;21(2):182\u20134."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/1\/article-p84.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/42\/1\/84\/1970783\/thij-14-4138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/1\/article-p84.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/1\/article-p84.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:29:44Z","timestamp":1730993384000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/1\/article-p84.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":8,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.14503\/thij-14-4138","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}