{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:29:41Z","timestamp":1780892981248,"version":"3.54.1"},"reference-count":8,"publisher":"Texas Heart Institute Journal","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12]]},"abstract":"Ephedrine decongestant products are widely used. Common side effects include palpitations, nervousness, and headache. More severe adverse reactions include cardiomyopathy and vasospasm. We report the case of an otherwise healthy 37-year-old woman who presented with acute-onset quadriplegia and heart failure. She had a normal chest radiograph on admission, but developed marked pulmonary edema and bilateral effusions the next day. Echocardiography revealed a left ventricular ejection fraction of 0.18 and no obvious intrinsic pathologic condition such as foramen narrowing on spinal imaging. Laboratory screening was positive for methamphetamines in the urine, and the patient admitted to having used, over the past several weeks, multiple ephedrine-containing products for allergy-symptom relief.<\/jats:p>\n She was ultimately diagnosed with an acute catecholamine-induced cardiomyopathy and spinal artery vasospasm consequential to excessive use of decongestants. Her symptoms resolved completely with supportive care and appropriate heart-failure management. An echocardiogram 2 weeks after admission showed improvement of the left ventricular ejection fraction to 0.33. Ten months after the event, the patient was entirely asymptomatic and showed further improvement of her ejection fraction to 0.45. To our knowledge, ours is the first report of spinal artery vasospasm resulting in quadriplegia in a human being after ephedrine ingestion.<\/jats:p>","DOI":"10.14503\/thij-14-4487","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T21:59:11Z","timestamp":1448920751000},"page":"575-578","source":"Crossref","is-referenced-by-count":6,"title":["Transient Cardiomyopathy and Quadriplegia Induced by Ephedrine Decongestant"],"prefix":"10.14503","volume":"42","author":[{"given":"David F.","family":"Snipelisky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Kurklinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Chirila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-42-6-575-b1","series-title":"Congest Heart Fail","first-page":"89","article-title":"Cardiomyopathy associated with ephedra-containing nutritional supplements","volume":"14","year":"2008","unstructured":"Singh\n A, \n \n Rajeev\n AG, \n \n Dohrmann\n ML.\n \n \n Cardiomyopathy associated with ephedra-containing nutritional supplements. Congest Heart Fail2008;14(2):89\u201390."},{"issue":"3","key":"i1526-6702-42-6-575-b2","series-title":"Ann Pharmacother","first-page":"400","article-title":"Ephedra-associated cardiomyopathy","volume":"38","year":"2004","unstructured":"Naik\n SD, \n \n Freudenberger\n RS.\n \n \n Ephedra-associated cardiomyopathy. Ann Pharmacother2004;38(3):400\u20133."},{"issue":"3","key":"i1526-6702-42-6-575-b3","series-title":"Braz J Med Biol Res","first-page":"339","article-title":"Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation","volume":"34","year":"2001","unstructured":"Puscas\n I, \n \n Coltau\n M, \n \n Gilau\n L, \n \n Pasca\n R, \n \n Domuta\n G, \n \n Baican\n M, \n \n Hecht\n A.\n \n \n Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation. Braz J Med Biol Res2001; 34(3):339\u201345."},{"issue":"4","key":"i1526-6702-42-6-575-b4","series-title":"J Neurosurg","first-page":"440","article-title":"Experimental catecholamine-induced chronic cerebral vasospasm. Myonecrosis in vessel wall","volume":"41","year":"1974","unstructured":"Alksne\n JF, \n \n Greenhoot\n JH.\n \n \n Experimental catecholamine-induced chronic cerebral vasospasm. Myonecrosis in vessel wall. J Neurosurg1974;41(4):440\u20135."},{"issue":"2\u20133","key":"i1526-6702-42-6-575-b5","series-title":"J Neurol Sci","first-page":"261","article-title":"Plasma catecholamine concentrations associated with cerebral vasospasm","volume":"45","year":"1980","unstructured":"Loach\n AB, \n \n Benedict\n CR.\n \n \n Plasma catecholamine concentrations associated with cerebral vasospasm. J Neurol Sci1980; 45(2\u20133):261\u201371."},{"issue":"2","key":"i1526-6702-42-6-575-b6","series-title":"Anesthesiology","first-page":"615","article-title":"Reversible catecholamine-induced cardiomyopathy by subcutaneous injections of epinephrine solution in an anesthetized patient","volume":"92","year":"2000","unstructured":"Sato\n Y, \n \n Tanaka\n M, \n \n Nishikawa\n T.\n \n \n Reversible catecholamine-induced cardiomyopathy by subcutaneous injections of epinephrine solution in an anesthetized patient. Anesthesiology2000;92(2):615\u20139."},{"issue":"1","key":"i1526-6702-42-6-575-b7","series-title":"J Cardiovasc Med (Hagerstown)","first-page":"49","article-title":"Initial presentation of pheochromocytoma with takotsubo cardiomyopathy: a brief review of literature","volume":"11","year":"2010","unstructured":"Gujja\n KR, \n \n Aslam\n AF, \n \n Privman\n V, \n \n Tejani\n F, \n \n Vasavada\n B.\n \n \n Initial presentation of pheochromocytoma with takotsubo cardiomyopathy: a brief review of literature. J Cardiovasc Med (Hagerstown)2010;11(1):49\u201352."},{"issue":"2","key":"i1526-6702-42-6-575-b8","series-title":"Anesth Analg","first-page":"410","article-title":"Catecholamine-induced cardiomyopathy and pheochromocytoma","volume":"107","year":"2008","unstructured":"Leissner\n KB, \n \n Mahmood\n F, \n \n Aragam\n JR, \n \n Amouzgar\n A, \n \n Ortega\n R.\n \n \n Catecholamine-induced cardiomyopathy and pheochromocytoma. Anesth Analg2008;107(2):410\u20132."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/6\/article-p575.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/42\/6\/575\/1969973\/thij-14-4487.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/6\/article-p575.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/42\/6\/article-p575.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:32:10Z","timestamp":1730993530000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/42\/6\/article-p575.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":8,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.14503\/thij-14-4487","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}