{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T19:41:17Z","timestamp":1745782877462,"version":"3.28.0"},"reference-count":11,"publisher":"Texas Heart Institute Journal","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"A 55-year-old woman was admitted for orthotopic heart transplantation. Her medical history was notable for multiple cardiovascular problems, including ischemic cardiomyopathy that necessitated circulatory support with a left ventricular assist device. Five weeks after undergoing orthotopic heart transplantation, she developed Aspergillus calidoustus<\/jats:italic> mediastinitis, for which she underwent a prolonged course of antifungal treatment that comprised (in sequence) posaconazole for 11 days, voriconazole for 10 days, and amphotericin B for 42 days. During this period, she also underwent repeated mediastinal drainage and sternal d\u00e9bridement, followed by sternal wiring and coverage with bilateral pectoralis advancement flaps. Four months postoperatively, she was discharged from the hospital with a successfully controlled infection and a healed sternum. To our knowledge, only 3 previous cases of Aspergillus<\/jats:italic> mediastinitis after orthotopic heart transplantation have been reported in the literature, none of which was Aspergillus calidoustus<\/jats:italic>.<\/jats:p>","DOI":"10.14503\/thij-14-4732","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T20:24:07Z","timestamp":1443731047000},"page":"468-470","source":"Crossref","is-referenced-by-count":11,"title":["Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report"],"prefix":"10.14503","volume":"42","author":[{"given":"Magdy M.","family":"El-Sayed Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkader","family":"Almanfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Aftab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari R.","family":"Mallidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.H.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"key":"i0730-2347-42-5-468-b1","series-title":"J Med Case Rep","first-page":"312","article-title":"Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report","volume":"4","year":"2010","unstructured":"Dimopoulos\n G, \n \n Tsangaris\n I, \n \n Poulakou\n G, \n \n Panayiotides\n J, \n \n Tsaknis\n G, \n \n Orfanos\n S, \n \n Armaganides\n A.\n \n \n Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report. J Med Case Rep2010;4:312."},{"issue":"11","key":"i0730-2347-42-5-468-b2","series-title":"Clin Microbiol Infect","first-page":"1060","article-title":"Post-operative aspergillosis","volume":"12","year":"2006","unstructured":"Pasqualotto\n AC, \n \n Denning\n DW.\n \n \n Post-operative aspergillosis. Clin Microbiol Infect2006;12(11):1060\u201376."},{"issue":"3","key":"i0730-2347-42-5-468-b3","series-title":"Transpl Infect Dis","first-page":"129","article-title":"Aspergillus mediastinitis following orthotopic heart transplantation: case report and review of the literature","volume":"6","year":"2004","unstructured":"Levin\n T, \n \n Suh\n B, \n \n Beltramo\n D, \n \n Samuel\n R.\n \n \n Aspergillus mediastinitis following orthotopic heart transplantation: case report and review of the literature. Transpl Infect Dis2004;6(3):129\u201331."},{"issue":"6","key":"i0730-2347-42-5-468-b4","series-title":"Ann Thorac Surg","first-page":"1039","article-title":"Mediastinitis in heart transplantation","volume":"54","year":"1992","unstructured":"Karwande\n SV, \n \n Renlund\n DG, \n \n Olsen\n SL, \n \n Gay\n WA, Jr, \n \n Richenbacher\n WE, \n \n Hawkins\n JA, \n \n et al. Mediastinitis in heart transplantation. Ann Thorac Surg1992;54(6):1039\u201345."},{"issue":"3 Pt 1","key":"i0730-2347-42-5-468-b5","series-title":"J Heart Lung Transplant","first-page":"545","article-title":"Bacterial mediastinitis after heart transplantation","volume":"11","year":"1992","unstructured":"Baldwin\n RT, \n \n Radovancevic\n B, \n \n Sweeney\n MS, \n \n Duncan\n JM, \n \n Frazier\n OH.\n \n \n Bacterial mediastinitis after heart transplantation. 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N Engl J Med1998;338(24):1741\u201351."},{"issue":"2","key":"i0730-2347-42-5-468-b8","series-title":"Heart Lung","first-page":"145","article-title":"Mediastinitis caused by Aspergillus fumigatus with ruptured aortic pseudoaneurysm in a heart transplant recipient: case study","volume":"22","year":"1993","unstructured":"Byl\n B, \n \n Jacobs\n F, \n \n Antoine\n M, \n \n Depierreux\n M, \n \n Serruys\n E, \n \n Primo\n G, \n \n Thys\n JP.\n \n \n Mediastinitis caused by Aspergillus fumigatus with ruptured aortic pseudoaneurysm in a heart transplant recipient: case study. Heart Lung1993;22(2):145\u20137."},{"issue":"5","key":"i0730-2347-42-5-468-b9","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"347","article-title":"A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole","volume":"24","year":"2005","unstructured":"Forestier\n E, \n \n Remy\n V, \n \n Lesens\n O, \n \n Martinot\n M, \n \n Hansman\n Y, \n \n Eisenmann\n B, \n \n Christmann\n D.\n \n \n A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole. Eur J Clin Microbiol Infect Dis2005;24(5):347\u20139."},{"issue":"4","key":"i0730-2347-42-5-468-b10","series-title":"Eukaryot Cell","first-page":"630","article-title":"Aspergillus calidoustus sp nov., causative agent of human infections previously assigned to Aspergillus ustus","volume":"7","year":"2008","unstructured":"Varga\n J, \n \n Houbraken\n J, \n \n Van Der Lee\n HA, \n \n Verweij\n PE, \n \n Samson\n RA.\n \n \n Aspergillus calidoustus sp nov., causative agent of human infections previously assigned to Aspergillus ustus. 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