{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:54:17Z","timestamp":1781049257358,"version":"3.54.1"},"reference-count":8,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Takotsubo cardiomyopathy, or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction caused by transient wall-motion abnormalities of the left ventricular apex and mid ventricle in the absence of obstructive coronary artery disease. Recurrent episodes are rare but have been reported, and several cases of takotsubo cardiomyopathy have been described in the presence of hyperthyroidism. We report the case of a 55-year-old woman who had recurrent takotsubo cardiomyopathy, documented by repeat coronary angiography and evaluations of left ventricular function, in the presence of recurrent hyperthyroidism related to Graves disease. After both episodes, the patient's left ventricular function returned to normal when her thyroid function normalized. These findings suggest a possible role of thyroid-hormone excess in the pathophysiology of some patients who have takotsubo cardiomyopathy.<\/jats:p>","DOI":"10.14503\/thij-15-5046","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T22:00:25Z","timestamp":1459893625000},"page":"152-155","source":"Crossref","is-referenced-by-count":11,"title":["Recurrent Takotsubo Cardiomyopathy Related to Recurrent Thyrotoxicosis"],"prefix":"10.14503","volume":"43","author":[{"given":"Keval","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"Griffing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Hauptman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Stolker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"11","key":"i0730-2347-43-2-152-b1","series-title":"Ann Intern Med","first-page":"858","article-title":"Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction","volume":"141","year":"2004","unstructured":"Bybee\n              KA,\n\t\t\t\t\t\t\n            \n              Kara\n              T,\n\t\t\t\t\t\t\n            \n              Prasad\n              A,\n\t\t\t\t\t\t\n            \n              Lerman\n              A,\n\t\t\t\t\t\t\n            \n              Barsness\n              GW,\n\t\t\t\t\t\t\n            \n              Wright\n              RS,\n\t\t\t\t\t\t\n            \n              Rihal\n              CS.\n            \n          \n          Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction.\n\t\t\t\t\tAnn Intern Med2004;\n\t\t\t\t\t141(\n\t\t\t\t\t11):\n\t\t\t\t\t858\u2013\n\t\t\t\t\t65."},{"issue":"25","key":"i0730-2347-43-2-152-b2","series-title":"Circulation","first-page":"2754","article-title":"Takotsubo cardiomyopathy: a new form of acute, reversible heart failure","volume":"118","year":"2008","unstructured":"Akashi\n              YJ,\n\t\t\t\t\t\t\n            \n              Goldstein\n              DS,\n\t\t\t\t\t\t\n            \n              Barbaro\n              G,\n\t\t\t\t\t\t\n            \n              Ueyama\n              T.\n            \n          \n          Takotsubo cardiomyopathy: a new form of acute, reversible heart failure.\n\t\t\t\t\tCirculation2008;\n\t\t\t\t\t118(\n\t\t\t\t\t25):\n\t\t\t\t\t2754\u2013\n\t\t\t\t\t62."},{"issue":"12","key":"i0730-2347-43-2-152-b3","series-title":"Thyroid","first-page":"1427","article-title":"Takotsubo cardiomyopathy precipitated by thyrotoxicosis","volume":"20","year":"2010","unstructured":"Alidjan\n              F,\n\t\t\t\t\t\t\n            \n              Ezzhati\n              M,\n\t\t\t\t\t\t\n            \n              Bruggeling\n              W,\n\t\t\t\t\t\t\n            \n              van Guldener\n              C.\n            \n          \n          Takotsubo cardiomyopathy precipitated by thyrotoxicosis.\n\t\t\t\t\tThyroid2010;\n\t\t\t\t\t20(\n\t\t\t\t\t12):\n\t\t\t\t\t1427\u2013\n\t\t\t\t\t8."},{"issue":"9","key":"i0730-2347-43-2-152-b4","series-title":"Thyroid","first-page":"975","article-title":"Takotsubo cardiomyopathy complicating thyroidectomy for Graves' disease","volume":"22","year":"2012","unstructured":"Gundara\n              JS,\n\t\t\t\t\t\t\n            \n              Lee\n              JC,\n\t\t\t\t\t\t\n            \n              Ip\n              J,\n\t\t\t\t\t\t\n            \n              Sidhu\n              SB.\n            \n          \n          Takotsubo cardiomyopathy complicating thyroidectomy for Graves' disease.\n\t\t\t\t\tThyroid2012;\n\t\t\t\t\t22(\n\t\t\t\t\t9):\n\t\t\t\t\t975\u2013\n\t\t\t\t\t6."},{"issue":"7","key":"i0730-2347-43-2-152-b5","series-title":"Jpn Circ J","first-page":"813","article-title":"Reversible left ventricular wall motion impairment caused by pheochromocytoma--a case report","volume":"53","year":"1989","unstructured":"Iga\n              K,\n\t\t\t\t\t\t\n            \n              Gen\n              H,\n\t\t\t\t\t\t\n            \n              Tomonaga\n              G,\n\t\t\t\t\t\t\n            \n              Matsumura\n              T,\n\t\t\t\t\t\t\n            \n              Hori\n              K.\n            \n          \n          Reversible left ventricular wall motion impairment caused by pheochromocytoma--a case report.\n\t\t\t\t\tJpn Circ J1989;\n\t\t\t\t\t53(\n\t\t\t\t\t7):\n\t\t\t\t\t813\u2013\n\t\t\t\t\t8."},{"key":"i0730-2347-43-2-152-b6","series-title":"Clinical aspects of myocardial injury: from ischemia to heart failure","first-page":"56","article-title":"Takotsubo-type cardiomyopathy due to multivessel spasm","year":"1990","unstructured":"Sato\n              H,\n\t\t\t\t\t\t\n            \n              Tateishi\n              H,\n\t\t\t\t\t\t\n            \n              Uchida\n              T.\n            \n          \n          Takotsubo-type cardiomyopathy due to multivessel spasm.\n\t\t\t\t\tIn:\n\t\t\t\t\tKodamaK,\n\t\t\t\t\t\tHazeK,\n\t\t\t\t\t\tHonM,\n\t\t\t\t\t\teditors [in Japanese].\n\t\t\t\t\tClinical aspects of myocardial injury: from ischemia to heart failure.\n\t\t\t\t\tTokyo:\n\t\t\t\t\tKagakuhyouronsha;\n\t\t\t\t\t1990.\n\t\t\t\t\tp.\n\t\t\t\t\t56\u2013\n\t\t\t\t\t64."},{"issue":"5","key":"i0730-2347-43-2-152-b7","series-title":"Jpn Heart J","first-page":"889","article-title":"Reversible left ventricular dysfunction \u201ctakotsubo\u201d cardiomyopathy associated with hyperthyroidism","volume":"45","year":"2004","unstructured":"Miyazaki\n              S,\n\t\t\t\t\t\t\n            \n              Kamiishi\n              T,\n\t\t\t\t\t\t\n            \n              Hosokawa\n              N,\n\t\t\t\t\t\t\n            \n              Komura\n              M,\n\t\t\t\t\t\t\n            \n              Konagai\n              H,\n\t\t\t\t\t\t\n            \n              Sagai\n              H,\n\t\t\t\t\t\t\n            \n              Takamoto\n              T.\n            \n          \n          Reversible left ventricular dysfunction \u201ctakotsubo\u201d cardiomyopathy associated with hyperthyroidism.\n\t\t\t\t\tJpn Heart J2004;\n\t\t\t\t\t45(\n\t\t\t\t\t5):\n\t\t\t\t\t889\u2013\n\t\t\t\t\t94."},{"issue":"15","key":"i0730-2347-43-2-152-b8","series-title":"Circulation","first-page":"1725","article-title":"Thyroid disease and the heart [published erratum appears in Circulation 2008;117(3):e18]","volume":"116","year":"2007","unstructured":"Klein\n              I,\n\t\t\t\t\t\t\n            \n              Danzi\n              S.\n            \n          \n          Thyroid disease and the heart [published erratum appears in Circulation 2008;117(3):e18].\n\t\t\t\t\tCirculation2007;\n\t\t\t\t\t116(\n\t\t\t\t\t15):\n\t\t\t\t\t1725\u2013\n\t\t\t\t\t35."}],"container-title":["Texas Heart Institute 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