{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:49:28Z","timestamp":1785592168222,"version":"3.56.0"},"reference-count":8,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Transcatheter aortic valve replacement (TAVR) is a well-established method for replacing native aortic valves; however, it was conceived for elderly patients with aortic valve stenosis, and the lack of data on long-term durability has led practitioners to restrict the use of TAVR to patients who have short life expectancies. Here, we describe the case of a 21-year-old woman who had undergone 3 previous open aortic valve replacements and who presented with symptoms of recurrent valvular failure. Transthoracic echocardiograms and computed tomographic angiograms revealed a degenerating aortic root homograft with substantial calcification, moderate-to-severe aortic valve stenosis, and severe aortic valve regurgitation. Open surgical valve replacement posed substantial risk to our patient, so we decided to perform valve-in-valve TAVR with use of the Edwards S<jats:sc>apien<\/jats:sc> XT Transcatheter Heart Valve. The patient's pulmonary artery pressure, valvular regurgitation, and symptoms improved substantially thereafter. We found that valve-in-valve TAVR into a failing aortic root homograft was less invasive than repeat surgical valve replacement in this young patient who had congenital vascular anomalies and a complex surgical history.<\/jats:p>","DOI":"10.14503\/thij-15-5128","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T21:08:19Z","timestamp":1470431299000},"page":"334-337","source":"Crossref","is-referenced-by-count":9,"title":["Transcatheter Aortic Valve-in-Valve Replacement Instead of a 4th Sternotomy in a 21-Year-Old Woman with Aortic Homograft Failure"],"prefix":"10.14503","volume":"43","author":[{"given":"Jos\u00e9 G.","family":"D\u00edez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G.","family":"Dougherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Preventza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Coselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"10","key":"i1526-6702-43-4-334-b1","series-title":"J Invasive Cardiol","first-page":"E197","article-title":"Transcatheter valve-in-valve implantation due to severe aortic regurgitation in a degenerated aortic homograft","volume":"21","year":"2009","unstructured":"Olsen\n              LK, \n            \n              Engstrom\n              T, \n            \n              Sondergaard\n              L.\n            \n          \n          Transcatheter valve-in-valve implantation due to severe aortic regurgitation in a degenerated aortic homograft. J Invasive Cardiol2009;21(10):E197\u2013200."},{"issue":"2 Suppl","key":"i1526-6702-43-4-334-b2","series-title":"Ann Thorac Surg","first-page":"S95","article-title":"Reoperative aortic valve operation after homograft root replacement: surgical options and results","volume":"60","year":"1995","unstructured":"Sundt\n              TM\n              3rd, \n            \n              Rasmi\n              N, \n            \n              Wong\n              K, \n            \n              Radley-Smith\n              R, \n            \n              Khaghani\n              A, \n            \n              Yacoub\n              MH.\n            \n          \n          Reoperative aortic valve operation after homograft root replacement: surgical options and results. 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