{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:22:07Z","timestamp":1785234127602,"version":"3.55.0"},"reference-count":6,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"Platypnea-orthodeoxia syndrome is a rare disease defined by dyspnea and deoxygenation, induced by an upright position, and relieved by recumbency. Causes include shunting through a patent foramen ovale and pulmonary arteriovenous malformations.<\/jats:p>\n A 79-year-old woman experienced 2 syncopal episodes at rest and presented at another hospital. In the emergency department, she was hypoxic, needing 6 L\/min of oxygen. Her chest radiograph showed nothing unusual. Transthoracic echocardiograms with saline microcavitation evaluation were mildly positive early after agitated-saline administration, suggesting intracardiac shunting. She was then transferred to our center.<\/jats:p>\n Right-sided heart catheterization revealed no oximetric evidence of intracardiac shunting while the patient was supine and had a low right atrial pressure. However, her oxygen saturation dropped to 78% when she sat up. Repeat transthoracic echocardiography while sitting revealed a dramatically positive early saline microcavitation-uptake into the left side of the heart. Transesophageal echocardiograms showed a patent foramen ovale, with right-to-left shunting highly dependent upon body position. The patient underwent successful percutaneous patent foramen ovale closure, and her oxygen supplementation was suspended.<\/jats:p>\n In patients with unexplained or transient hypoxemia in which a cardiac cause is suspected, it is important to evaluate shunting in both the recumbent and upright positions. In this syndrome, elevated right atrial pressure is not necessary for significant right-to-left shunting. Percutaneous closure, if feasible, is first-line therapy in these patients.<\/jats:p>","DOI":"10.14503\/thij-15-5280","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T16:11:30Z","timestamp":1465229490000},"page":"264-266","source":"Crossref","is-referenced-by-count":10,"title":["Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question"],"prefix":"10.14503","volume":"43","author":[{"given":"Michael R.","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd L.","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Velazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"1","key":"i1526-6702-43-3-264-b1","series-title":"Cardiology","first-page":"15","article-title":"Platypnea-orthodeoxia syndrome in review: defining a new disease?","volume":"123","year":"2012","unstructured":"Rodrigues\n P, \n \n Palma\n P, \n \n Sousa-Pereira\n L.\n \n \n Platypnea-orthodeoxia syndrome in review: defining a new disease?\n Cardiology\n 2012;123(1):15\u201323."},{"issue":"2","key":"i1526-6702-43-3-264-b2","series-title":"Chest","first-page":"553","article-title":"Platypnea-orthodeoxia syndrome related to an aortic aneurysm combined with an aneurysm of the atrial septum","volume":"118","year":"2000","unstructured":"Faller\n M, \n \n Kessler\n R, \n \n Chaouat\n A, \n \n Ehrhart\n M, \n \n Petit\n H, \n \n Weitzenblum\n E.\n \n \n Platypnea-orthodeoxia syndrome related to an aortic aneurysm combined with an aneurysm of the atrial septum. Chest2000;118(2):553\u20137."},{"issue":"6","key":"i1526-6702-43-3-264-b3","series-title":"Circulation","first-page":"741","article-title":"Platypnea-orthodeoxia due to aortic elongation","volume":"104","year":"2001","unstructured":"Medina\n A, \n \n de Lezo\n JS, \n \n Caballero\n E, \n \n Ortega\n JR.\n \n \n Platypnea-orthodeoxia due to aortic elongation. Circulation2001;104(6):741."},{"issue":"2","key":"i1526-6702-43-3-264-b4","series-title":"Cardiovasc Intervent Radiol","first-page":"164","article-title":"Transcatheter closure of patent foramen ovale in patients with platypnea-orthodeoxia: results of a multicentric French registry","volume":"28","year":"2005","unstructured":"Guerin\n P, \n \n Lambert\n V, \n \n Godart\n F, \n \n Legendre\n A, \n \n Petit\n J, \n \n Bourlon\n F, \n \n et al. Transcatheter closure of patent foramen ovale in patients with platypnea-orthodeoxia: results of a multicentric French registry. Cardiovasc Intervent Radiol2005;28(2):164\u20138."},{"issue":"1","key":"i1526-6702-43-3-264-b5","series-title":"Catheter Cardiovasc Interv","first-page":"77","article-title":"Platypnea-orthodeoxia: management by transcatheter buttoned device implantation","volume":"54","year":"2001","unstructured":"Rao\n PS, \n \n Palacios\n IF, \n \n Bach\n RG, \n \n Bitar\n SR, \n \n Sideris\n EB.\n \n \n Platypnea-orthodeoxia: management by transcatheter buttoned device implantation. Catheter Cardiovasc Interv2001;54(1):77\u201382."},{"issue":"10","key":"i1526-6702-43-3-264-b6","series-title":"J Invasive Cardiol","first-page":"578","article-title":"Management of platypnea-orthodeoxia syndrome by transcatheter closure of atrial communication: hemodynamic characteristics, clinical and echocardiographic outcome","volume":"16","year":"2004","unstructured":"Delgado\n G, \n \n Inglessis\n I, \n \n Martin-Herrero\n F, \n \n Yoerger\n D, \n \n Liberthson\n R, \n \n Buoanno\n F, \n \n Palacios\n I.\n \n \n Management of platypnea-orthodeoxia syndrome by transcatheter closure of atrial communication: hemodynamic characteristics, clinical and echocardiographic outcome. J Invasive Cardiol2004;16(10):578\u201382."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/43\/3\/article-p264.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/43\/3\/264\/1971826\/thij-15-5280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/43\/3\/article-p264.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/43\/3\/article-p264.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:32:17Z","timestamp":1730993537000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/43\/3\/article-p264.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":6,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.14503\/thij-15-5280","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}