{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:05:04Z","timestamp":1788228304722,"version":"build-2803163510"},"reference-count":21,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Mitral valve leaflet aneurysm is a rare and potentially devastating complication of aortic valve endocarditis. We report the case of a 48-year-old man who had endocarditis of the native aortic valve and a concomitant aneurysm of the anterior mitral valve leaflet. Severe mitral regurgitation occurred after the aneurysm perforated. The patient showed no signs of heart failure and completed a 6-week regimen of antibiotic therapy before undergoing successful aortic and mitral valve replacement. In addition to the patient's case, we review the relevant medical literature.<\/jats:p>","DOI":"10.14503\/thij-15-5322","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T21:08:19Z","timestamp":1470431299000},"page":"345-349","source":"Crossref","is-referenced-by-count":22,"title":["Infective Endocarditis of the Aortic Valve with Anterior Mitral Valve Leaflet Aneurysm"],"prefix":"10.14503","volume":"43","author":[{"given":"Anton","family":"Tomsic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson W.L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"van Paridon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin R.","family":"Bindraban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas A.J.M.","family":"de Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"1","key":"i1526-6702-43-4-345-b1","series-title":"Anesth Analg","first-page":"86","article-title":"Echo rounds: aneurysm of the anterior mitral valve","volume":"114","year":"2012","unstructured":"Stechert\n              MM, \n            \n              Pletcher\n              JR, \n            \n              Tseng\n              EE, \n            \n              London\n              MJ.\n            \n          \n          Echo rounds: aneurysm of the anterior mitral valve. Anesth Analg2012;114(1):86\u20138."},{"issue":"1","key":"i1526-6702-43-4-345-b2","series-title":"J Saudi Heart Assoc","first-page":"47","article-title":"Impressive echocardiographic images of a rare pathology: aneurysm of the mitral valve - report of two cases and review of the literature","volume":"25","year":"2013","unstructured":"Al-Refai\n              MA, \n            \n              Oueida\n              FM, \n            \n              Lui\n              RC, \n            \n              Al-Saif\n              SM, \n            \n              Al-Omran\n              HM.\n            \n          \n          Impressive echocardiographic images of a rare pathology: aneurysm of the mitral valve - report of two cases and review of the literature. J Saudi Heart Assoc2013;25(1):47\u201351."},{"issue":"9","key":"i1526-6702-43-4-345-b3","series-title":"Cleve Clin J Med","first-page":"559","article-title":"The clinical picture: fever, dyspnea, and a new heart murmur","volume":"80","year":"2013","unstructured":"Jackson\n              G, \n            \n              Camargo\n              C, \n            \n              Ling\n              LF, \n            \n              Kalahasti\n              V, \n            \n              Rimmerman\n              CM.\n            \n          \n          The clinical picture: fever, dyspnea, and a new heart murmur. Cleve Clin J Med2013;80(9):559\u201361."},{"issue":"19","key":"i1526-6702-43-4-345-b4","series-title":"Eur Heart J","first-page":"2369","article-title":"Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). 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Am J Cardiol1999;84(1):110\u20133, A9."},{"issue":"11","key":"i1526-6702-43-4-345-b6","series-title":"J Am Soc Echocardiogr","first-page":"1050","article-title":"Aneurysm of the anterior leaflet of the mitral valve secondary to aortic valve endocarditis","volume":"13","year":"2000","unstructured":"Marcos-Alberca\n              P, \n            \n              Rey\n              M, \n            \n              Serrano\n              JM, \n            \n              Fernandez-Rozas\n              I, \n            \n              Navarro\n              F, \n            \n              Contreras\n              A, \n            \n              Rabago\n              R.\n            \n          \n          Aneurysm of the anterior leaflet of the mitral valve secondary to aortic valve endocarditis. 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Indian Heart J2012;64(4):402\u20133."},{"issue":"3","key":"i1526-6702-43-4-345-b10","series-title":"Echocardiography","first-page":"E72","article-title":"Ruptured anterior mitral leaflet aneurysm in aortic valve infective endocarditis--evaluation by three-dimensional echocardiography","volume":"31","year":"2014","unstructured":"Kharwar\n              RB, \n            \n              Mohanty\n              A, \n            \n              Sharma\n              A, \n            \n              Narain\n              VS, \n            \n              Sethi\n              R.\n            \n          \n          Ruptured anterior mitral leaflet aneurysm in aortic valve infective endocarditis--evaluation by three-dimensional echocardiography. Echocardiography2014;31(3):E72\u20136."},{"issue":"3","key":"i1526-6702-43-4-345-b11","series-title":"Int J Cardiovasc Imaging","first-page":"535","article-title":"Clinical and echocardiographic evaluation of mitral valve aneurysms: a retrospective, single center study","volume":"30","year":"2014","unstructured":"Guler\n              A, \n            \n              Karabay\n              CY, \n            \n              Gursoy\n              OM, \n            \n              Guler\n              Y, \n            \n              Candan\n              O, \n            \n              Akgun\n              T, \n          \n          et al. Clinical and echocardiographic evaluation of mitral valve aneurysms: a retrospective, single center study. Int J Cardiovasc Imaging2014;30(3):535\u201341."},{"issue":"5","key":"i1526-6702-43-4-345-b12","series-title":"J Cardiothorac Vasc Anesth","first-page":"1432","article-title":"An unusual cause of severe mitral regurgitation in a patient with aortic valve endocarditis","volume":"28","year":"2014","unstructured":"Eiseman\n              MS, \n            \n              Schroeder\n              AR, \n            \n              Rutkowski\n              PS, \n            \n              Rashid\n              ZA, \n            \n              Pagel\n              PS.\n            \n          \n          An unusual cause of severe mitral regurgitation in a patient with aortic valve endocarditis. J Cardiothorac Vasc Anesth2014;28(5):1432\u20134."},{"issue":"26","key":"i1526-6702-43-4-345-b13","series-title":"N Engl J Med","first-page":"2466","article-title":"Early surgery versus conventional treatment for infective endocarditis","volume":"366","year":"2012","unstructured":"Kang\n              DH, \n            \n              Kim\n              YJ, \n            \n              Kim\n              SH, \n            \n              Sun\n              BJ, \n            \n              Kim\n              DH, \n            \n              Yun\n              SC, \n          \n          et al. Early surgery versus conventional treatment for infective endocarditis. N Engl J Med2012;366(26):2466\u201373."},{"issue":"4","key":"i1526-6702-43-4-345-b14","series-title":"J Thorac Cardiovasc Surg","first-page":"836","article-title":"Impact of early surgery in the active phase on long-term outcomes in left-sided native valve infective endocarditis","volume":"142","year":"2011","unstructured":"Funakoshi\n              S, \n            \n              Kaji\n              S, \n            \n              Yamamuro\n              A, \n            \n              Tani\n              T, \n            \n              Kinoshita\n              M, \n            \n              Okada\n              Y, \n            \n              Furukawa\n              Y.\n            \n          \n          Impact of early surgery in the active phase on long-term outcomes in left-sided native valve infective endocarditis. 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The association between the timing of valve surgery and 6-month mortality in left-sided infective endocarditis [published erratum appears in Heart 2008;94(11):1496]. Heart2008;94(7):892\u20136."},{"issue":"5","key":"i1526-6702-43-4-345-b18","series-title":"J Thorac Cardiovasc Surg","first-page":"766","article-title":"Aortic and mitral valve replacement with reconstruction of the intervalvular fibrous body","volume":"114","year":"1997","unstructured":"David\n              TE, \n            \n              Kuo\n              J, \n            \n              Armstrong\n              S.\n            \n          \n          Aortic and mitral valve replacement with reconstruction of the intervalvular fibrous body. 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