{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:06:33Z","timestamp":1774267593069,"version":"3.50.1"},"reference-count":25,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Crucial to the management of staphylococcal bacteremia is an accurate evaluation of associated endocarditis, which has both therapeutic and prognostic implications. Because the clinical presentation of endocarditis can be nonspecific, the judicious use of echocardiography is important in distinguishing patients at high risk of developing endocarditis. In the presence of high-risk clinical features, an early transesophageal echocardiogram is warranted without prior transthoracic echocardiography.<\/jats:p>\n        <jats:p>The purpose of this study was to investigate the clinical risk factors for staphylococcal infective endocarditis that might warrant earlier transesophageal echocardiography and to describe the incidence of endocarditis in cases of methicillin-resistant and methicillin-sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia.<\/jats:p>\n        <jats:p>A retrospective case-control study was conducted by means of chart review of 91 patients consecutively admitted to a community hospital from January 2009 through January 2013. Clinical risk factors of patients with staphylococcal bacteremia were compared with risk factors of patients who had definite diagnoses of infective endocarditis. There were 69 patients with bacteremia alone (76%) and 22 patients with endocarditis (24%), as verified by echocardiography. Univariate analysis showed that diabetes mellitus (<jats:italic>P<\/jats:italic>=0.024), the presence of an automatic implantable cardioverter-defibrillator\/pacemaker (<jats:italic>P<\/jats:italic>=0.006) or a prosthetic heart valve (<jats:italic>P<\/jats:italic>=0.003), and recent hospitalization (<jats:italic>P<\/jats:italic>=0.048) were significantly associated with developing infective endocarditis in patients with <jats:italic>S. aureus<\/jats:italic> bacteremia. The incidence of methicillin-resistant and methicillin-sensitive <jats:italic>S. aureus<\/jats:italic> bacteremia was similar in the bacteremia and infective-endocarditis groups (<jats:italic>P<\/jats:italic>=0.437).<\/jats:p>\n        <jats:p>In conclusion, identified high-risk clinical factors in the presence of bacteremia can suggest infective endocarditis. Early evaluation with transesophageal echocardiography might well be warranted.<\/jats:p>","DOI":"10.14503\/thij-15-5359","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T22:25:30Z","timestamp":1487370330000},"page":"10-15","source":"Crossref","is-referenced-by-count":28,"title":["Clinical Risk Factors for Infective Endocarditis in Staphylococcus aureus Bacteremia"],"prefix":"10.14503","volume":"44","author":[{"given":"Vincent Bryan D.","family":"Salvador","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bikash","family":"Chapagain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astha","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra J.","family":"Brennessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"4","key":"i1526-6702-44-1-10-b1","series-title":"J Infect","first-page":"246","article-title":"The changing clinical aspects of infective endocarditis: descriptive review of 90 episodes in a French teaching hospital and risk factors for death","volume":"45","year":"2002","unstructured":"Mouly\n              S\n            , RuimyR, LaunayO, ArnoultF, BrochetE, TrouilletJL, \n          et al. 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Clin Microbiol Infect2004;10(6):556\u201361."},{"issue":"24","key":"i1526-6702-44-1-10-b3","series-title":"JAMA","first-page":"3012","article-title":"Staphylococcus aureus endocarditis: a consequence of medical progress","volume":"293","year":"2005","unstructured":"Fowler\n              VG\n              Jr\n            , MiroJM, HoenB, CabellCH, AbrutynE, RubinsteinE, \n          et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA2005;293(24):3012\u201321."},{"issue":"2","key":"i1526-6702-44-1-10-b4","series-title":"Eur Heart J","first-page":"196","article-title":"Infective endocarditis: changing epidemiology and predictors of 6 month mortality: a prospective cohort study","volume":"28","year":"2007","unstructured":"Hill\n              EE\n            , HerijgersP, ClausP, VanderschuerenS, HerregodsMC, PeetermansWE. \n          Infective endocarditis: changing epidemiology and predictors of 6 month mortality: a prospective cohort study. 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